Virtual and Augmented Reality Guidance for Hepatic RFA

肝脏 RFA 的虚拟和增强现实指导

• 批准号: 7263111
• 负责人: Henry Fuchs
• 金额: $ 50.76万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-17 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7263111
• 关键词: Ablation; Animal Model; Animals; Arts; Biopsy; Brachytherapy; Calibration; Cancerous; Chemoembolization; Class; Clinical; Compatible; Complex; Computers; Cryosurgery; Data; Depth; Development; Devices; Educational process of instructing; Future; Goals; Hepatic; Hepatic Radiofrequency Ablation; Human; Imagery; Lesion; Life; Localized; Magnetic Resonance Imaging; Mainstreaming; Measurement; Measures; Medical; Methods; Modeling; Outcome; Patients; Performance; Phase; Physicians; Placement; Primary carcinoma of the liver cells; Procedures; Radioactive; Radiofrequency Interstitial Ablation; Randomized Controlled Trials; Rate; Recurrence; Relative (related person); Research; Research Personnel; Safety; Seeds; Site; Standards of Weights and Measures; System; Techniques; Therapeutic Human Experimentation; Training; Ultrasonography; Validation; Woodchuck; human study; improved; in vivo; member; phantom model; programs; tool; trial comparing; tumor; two-dimensional; user-friendly; virtual

DESCRIPTION (provided by applicant): The primary goal of this project is to improve the clinical outcomes of hepatic radiofrequency ablation (RFA) therapy using state-of-the-art computer visualization techniques. We hypothesize that physicians will be more accurate in targeting RFA therapy to hepatic tumors using a contextually-correct three-dimensional (3D) visualization system than they could be with standard two-dimensional ultrasound alone. If proven beneficial, this technique could be used to decrease the post-RFA tumor recurrence rate (currently 33-48%) and improve the lives of thousands of patients with hepatic tumors annually. This study will proceed through four major phases of research: validation of our quantitative RFA phantom and segmentation methods; a large, randomized controlled trial comparing several methods of RFA guidance using our RFA phantoms; a randomized, controlled trial using the woodchuck model of hepatocellular carcinoma; and, a small randomized, controlled trial of safety and efficacy in humans. In addition, we will conduct several technical and synergistic research efforts, including improving the calibration of clinical display systems, developing fully automatic, continuous calibration methods for such systems, and determining the efficacy of enhanced guidance systems for teaching RFA techniques to novice physicians. The most immediate potential benefit of this research could be reduced tumor recurrence near RFA sites because of more accurate placement and estimation of the ablation zone boundaries. This research will also serve as the groundwork for the development of more sophisticated guidance systems to enable treatment of large and more complex lesions. Because of the similarity of this placement task to many other clinical ablation or biopsy tasks, we expect that these results would have applicability well beyond hepatic RFA. Finally, we may find that this system is effective for training novice users in the conduct of spatially complex procedures like RFA. This study will also provide two (2) important therapeutic research tools that are currently lacking for RFA: a quantitative accuracy phantom and a large animal model for in vivo hepatic tumors. The quantitative phantom will allow groups to evaluate new techniques for accurate RFA placement and ablation zone prediction and measurement. The woodchuck model will allow for more realistic in vivo experimentation as a step before human studies.

描述（由申请人提供）：该项目的主要目标是利用最先进的计算机可视化技术改善肝脏射频消融（RFA）治疗的临床结果。我们假设，与单独使用标准二维超声相比，医生使用上下文正确的三维 (3D) 可视化系统可以更准确地针对肝脏肿瘤进行 RFA 治疗。如果被证明是有益的，该技术可用于降低 RFA 后肿瘤复发率（目前为 33-48%），并每年改善数千名肝肿瘤患者的生活。本研究将通过四个主要研究阶段进行：验证我们的定量 RFA 体模和分割方法；一项大型随机对照试验，比较使用我们的 RFA 模型进行 RFA 引导的几种方法；使用肝细胞癌土拨鼠模型进行的随机对照试验；以及一项针对人类安全性和有效性的小型随机对照试验。此外，我们还将开展多项技术和协同研究工作，包括改进临床显示系统的校准，为此类系统开发全自动、连续校准方法，以及确定增强指导系统向新手医生教授 RFA 技术的有效性。这项研究最直接的潜在好处可能是减少 RFA 部位附近的肿瘤复发，因为消融区域边界的放置和估计更加准确。这项研究还将为开发更复杂的引导系统奠定基础，从而能够治疗大型和更复杂的病变。由于这种放置任务与许多其他临床消融或活检任务相似，我们预计这些结果的适用性将远远超出肝脏 RFA。最后，我们可能会发现该系统对于培训新手用户执行 RFA 等空间复杂程序非常有效。这项研究还将提供 RFA 目前缺乏的两 (2) 个重要的治疗研究工具：定量精确的模型和体内肝肿瘤的大型动物模型。定量体模将允许各小组评估新技术，以实现准确的 RFA 放置以及消融区域预测和测量。作为人体研究之前的一步，土拨鼠模型将允许进行更真实的体内实验。

项目成果

Optimizing a head-tracked stereo display system to guide hepatic tumor ablation.

优化头部跟踪立体显示系统以指导肝脏肿瘤消融。

• 发表时间: 2008
• 期刊: Studies in health technology and informatics
• 作者: Fuchs,Henry;State,Andrei;Yang,Hua;Peck,Tabitha;Lee,SangWoo;Rosenthal,Michael;Bulysheva,Anna;Burke,Charles
• 通讯作者: Burke,Charles