Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition

金属和有机氯暴露：对青少年行为和认知的影响

• 批准号: 7132131
• 负责人: SUSAN A KORRICK
• 金额: $ 61.23万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-08 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7132131
• 关键词: adolescence (12-20); arsenic; attention; behavioral /social science research tag; child behavior; child psychology; chlorohydrocarbon insecticide; clinical research; cognition; early experience; embryo /fetus toxicology; environmental exposure; executive function; halobiphenyl /halotriphenyl compound; hexachlorobenzene; human subject; impulsive behavior; lead; learning; longitudinal human study; manganese; memory; mental health epidemiology; metals; methylmercury

DESCRIPTION (provided by investigator): Children are exposed to a mix of potential neurotoxicants, including metals, via widespread contamination of food, air, soil and, in some settings, water. Exposure to neurotoxicants during early development can be particularly deleterious. Furthermore, the substantial developmental and physiologic changes of adolescence have been shown to be sensitive to early life exposures and experience. Therefore adolescence represents a critical time for manifestations of early life exposure effects but there are few environmental epidemiologic studies of this age group. The primary aims of this study are to assess the relation of early life exposure to neurotoxic metal mixtures, and their interactions, with early adolescent behavior and cognition. The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and postnatal Pb exposure. We will assess the relation of early life exposure to these metals, individually and jointly, with (1) behavior and cognition, particularly impulsive or hyperactive behaviors, attention, language skill, executive function, memory and learning skills among 13-year-olds; and (2) prospective changes in behavior and cognition between ages 8 and 13 years. (3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of metal-behavior/cognitive associations. The proposed study population is a well characterized cohort of 788 children born between 1993-1998, residing adjacent to a PCBand metal-contaminated site and with low-level to moderate metal exposures. Prenatal Pb and organochlorine exposure measures, and archived cord blood, maternal hair and toenail specimens were obtained at birth and the children had developmental assessments from birth through age 8 years. In this study, archived birth specimens will be analyzed for Mn, MeHg, and As and detailed cognitive/behavioral assessments will be performed at age13 years on 500 of the children. The relation of metal exposures with neurocognitive skills will be assessed individually and with interaction terms for each outcome. Then, the relation of individual and multiple exposure measures with potentially correlated outcomes will be evaluated in a single multiple outcomes model. The study's behavioral and cognitive assessments will measures skills directly related to the risk of childhood learning and behavioral disorders. These increasing common childhood disorders represent a growing source of childhood and, in many cases, later life morbidity and public health concern. The proposed study provides a unique opportunity (given extensive prospective exposure/developmental information and specimen archives already available) to gain insight into potentially remediable risk factors for common behavioral and learning disorders of childhood at a time, adolescence, when there may be increasingly evident functional and behavioral manifestations of early life neurotoxicant exposures.

描述（由调查者提供）：儿童通过广泛的食物、空气、土壤和某些环境下的水的污染，暴露于包括金属在内的潜在神经毒物的混合物中。在早期发育阶段接触神经毒物尤其有害。此外，青少年的实质性发展和生理变化已被证明是敏感的早期生活暴露和经验。因此，青春期是早期生活暴露效应表现的关键时期，但对这一年龄组的环境流行病学研究很少。本研究的主要目的是评估生命早期接触神经毒性金属混合物及其相互作用与青少年早期行为和认知的关系。要研究的金属是产前锰（Mn）、甲基汞（MeHg）、砷（As）、铅（Pb）和产后铅暴露。我们将评估早期生活暴露于这些金属的关系，单独和共同，与(1)