Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
金属和有机氯暴露:对青少年行为和认知的影响
基本信息
- 批准号:7285315
- 负责人:
- 金额:$ 58.93万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-09-08 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:13 year oldAdolescenceAdolescent BehaviorAdolescent DevelopmentAgeAirArchivesAreaArsenicAttentionBehaviorBehavior ControlBehavior DisordersBehavior assessmentBehavioralBirthBostonCaliforniaChildChildhoodChlorinated HydrocarbonsCognitionCognitiveCommunitiesDevelopmentDiseaseElderlyEnvironmental PollutionEnvironmental Risk FactorEpidemiologic StudiesExposure toFood ContaminationHairHazardous Waste SitesHexachlorobenzeneHyperactive behaviorImpairmentIndividualJointsLanguageLeadLearningLearning DisordersLifeManganeseMeasuresMemoryMetal exposureMetalsMethylmercury CompoundsModelingMorbidity - disease rateNamesNeurocognitiveNeurotoxinsOutcomePhysiologicalPolychlorinated BiphenylsPopulationPopulation StudyPublic HealthRangeResearch PersonnelRiskRisk FactorsRoleShort-Term MemorySiteSoilSourceSpecimenStagingStructure of nail of toeSystemTestingTimeUmbilical Cord BloodVerbal LearningWaterWorkage groupage relatedblood leadcohortexecutive functionexperienceinsightlead exposureneurotoxicorganochlorine exposureperformance testspostnatalprenatalprenatal exposureprospectiveresearch clinical testingskill acquisitionskills
项目摘要
DESCRIPTION (provided by investigator): Children are exposed to a mix of potential neurotoxicants, including metals, via widespread contamination of food, air, soil and, in some settings, water. Exposure to neurotoxicants during early development can be particularly deleterious. Furthermore, the substantial developmental and physiologic changes of adolescence have been shown to be sensitive to early life exposures and experience. Therefore adolescence represents a critical time for manifestations of early life exposure effects but there are few environmental epidemiologic studies of this age group. The primary aims of this study are to assess the relation of early life exposure to neurotoxic metal mixtures, and their interactions, with early adolescent behavior and cognition. The metals to be studied are prenatal manganese (Mn), methylmercury (MeHg), arsenic (As), lead (Pb) and postnatal Pb exposure. We will assess the relation of early life exposure to these metals, individually and jointly, with (1)
behavior and cognition, particularly impulsive or hyperactive behaviors, attention, language skill, executive function, memory and learning skills among 13-year-olds; and (2) prospective changes in behavior and cognition between ages 8 and 13 years. (3) In addition, we will assess the role of prenatal exposure to prevalent organochlorines - polychlorinated biphenyls (PCBs), dichlorodiphenyl dichloroethene (DDE), and hexachlorobenzene (HCB) -- as effect modifiers of metal-behavior/cognitive associations. The proposed study population is a well characterized cohort of 788 children born between 1993-1998, residing adjacent to a PCBand metal-contaminated site and with low-level to moderate metal exposures. Prenatal Pb and organochlorine exposure measures, and archived cord blood, maternal hair and toenail specimens were obtained at birth and the children had developmental assessments from birth through age 8 years. In this study, archived birth specimens will be analyzed for Mn, MeHg, and As and detailed cognitive/behavioral assessments will be performed at age13 years on 500 of the children. The relation of metal exposures with neurocognitive skills will be assessed individually and with interaction terms for each outcome. Then, the relation of individual and multiple exposure measures with potentially correlated outcomes will be evaluated in a single multiple outcomes model. The study's behavioral and cognitive assessments will measures skills directly related to the
risk of childhood learning and behavioral disorders. These increasing common childhood disorders represent a growing source of childhood and, in many cases, later life morbidity and public health concern. The proposed study provides a unique opportunity (given extensive prospective exposure/developmental information and specimen archives already available) to gain insight into potentially remediable risk factors for common behavioral and learning disorders of childhood at a time, adolescence, when there may be increasingly evident functional and behavioral manifestations of early life neurotoxicant exposures.
描述(由研究者提供):儿童通过食物、空气、土壤和某些环境中的水的广泛污染暴露于潜在神经毒物的混合物,包括金属。在早期发育过程中暴露于神经毒物可能特别有害。此外,青春期的实质性发育和生理变化已被证明对早期生活的暴露和经历很敏感。因此,青春期是生命早期暴露效应表现的关键时期,但很少有这一年龄组的环境流行病学研究。本研究的主要目的是评估生命早期暴露于神经毒性金属混合物的关系,以及它们之间的相互作用,与早期青少年的行为和认知。研究的金属是产前锰(Mn),甲基汞(MeHg),砷(As),铅(Pb)和出生后铅暴露。我们将评估生命早期暴露于这些金属的关系,单独和联合,与(1)
13岁儿童的行为和认知,特别是冲动或多动行为、注意力、语言技能、执行功能、记忆和学习技能;以及(2)8至13岁之间行为和认知的预期变化。(3)此外,我们将评估产前暴露于流行的有机氯的作用-多氯联苯(PCBs),二氯二苯二氯乙烯(DDE),六氯苯(HCB)-作为金属行为/认知协会的效果调节剂。拟议的研究人群是一个特征明确的队列,包括1993-1998年出生的788名儿童,这些儿童居住在多氯联苯和金属污染场地附近,并有低水平至中度的金属暴露。产前铅和有机氯暴露的措施,并存档脐带血,母亲的头发和脚趾甲标本出生时获得的儿童从出生到8岁的发育评估。在这项研究中,将分析存档的出生标本中的锰、甲基汞和砷,并对其中500名13岁的儿童进行详细的认知/行为评估。金属暴露与神经认知技能的关系将单独评估,并与每个结果的相互作用项。然后,将在单一多结局模型中评价个体和多重暴露措施与潜在相关结局的关系。这项研究的行为和认知评估将衡量与这些技能直接相关的技能。
儿童期学习和行为障碍的风险。这些日益常见的儿童期疾病是儿童期疾病的一个日益增长的来源,在许多情况下,也是晚年发病率和公共卫生问题的一个日益增长的来源。拟议的研究提供了一个独特的机会(考虑到广泛的前瞻性暴露/发育信息和标本档案已经可用),以深入了解儿童期常见行为和学习障碍的潜在可补救风险因素,青春期,当生命早期神经毒素暴露可能有越来越明显的功能和行为表现时。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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SUSAN A KORRICK其他文献
SUSAN A KORRICK的其他文献
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{{ truncateString('SUSAN A KORRICK', 18)}}的其他基金
Research Experience and Training Coordination Core (RETCC)
研究经验和培训协调核心(RETCC)
- 批准号:
10559482 - 财政年份:2020
- 资助金额:
$ 58.93万 - 项目类别:
Research Experience and Training Coordination Core (RETCC)
研究经验和培训协调核心(RETCC)
- 批准号:
10332728 - 财政年份:2020
- 资助金额:
$ 58.93万 - 项目类别:
Research Experience and Training Coordination Core (RETCC)
研究经验和培训协调核心(RETCC)
- 批准号:
10112921 - 财政年份:2020
- 资助金额:
$ 58.93万 - 项目类别:
Environmental risk factors for autistic behaviors in a cohort study
队列研究中自闭症行为的环境危险因素
- 批准号:
9118996 - 财政年份:2015
- 资助金额:
$ 58.93万 - 项目类别:
Environmental risk factors for autistic behaviors in a cohort study
队列研究中自闭症行为的环境危险因素
- 批准号:
8890932 - 财政年份:2015
- 资助金额:
$ 58.93万 - 项目类别:
Project 2: Adolescent Exposure to BPA/Phthalates: Cognitive & Behavioral
项目 2:青少年接触 BPA/邻苯二甲酸盐:认知
- 批准号:
8375029 - 财政年份:2011
- 资助金额:
$ 58.93万 - 项目类别:
Project 2: Adolescent Exposure to BPA/Phthalates: Cognitive & Behavioral
项目 2:青少年接触 BPA/邻苯二甲酸盐:认知
- 批准号:
7846647 - 财政年份:2010
- 资助金额:
$ 58.93万 - 项目类别:
Project 2: Adolescent Exposure to BPA/Phthalates: Cognitive & Behavioral
项目 2:青少年接触 BPA/邻苯二甲酸盐:认知
- 批准号:
8208665 - 财政年份:2010
- 资助金额:
$ 58.93万 - 项目类别:
Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
金属和有机氯暴露:对青少年行为和认知的影响
- 批准号:
7909547 - 财政年份:2009
- 资助金额:
$ 58.93万 - 项目类别:
Metal and Organochlorines Exposure: Impact on Adolescent Behavior and Cognition
金属和有机氯暴露:对青少年行为和认知的影响
- 批准号:
7132131 - 财政年份:2006
- 资助金额:
$ 58.93万 - 项目类别:
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