Neurotoxic Interactions of Different Forms of Mercury

不同形式汞的神经毒性相互作用

基本信息

  • 批准号:
    7119662
  • 负责人:
  • 金额:
    $ 35.97万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-09-06 至 2008-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Public anxieties about mercury exposure have been aroused by reports about the hazards of fish consumption, dental amalgams, and preservatives in vaccines. Although scientific support for such concerns may be tenuous, it is also true that sizable gaps remain in our understanding of mercury neurotoxicity, especially with respect to combined exposures to different species, a commonplace condition. The two forms that present the greatest health risks are methylmercury, found in fish and marine mammals, and metallic mercury vapor, found in industry, cosmetics, and dental amalgams. Mechanistic analyses and limited experimental data indicate that co-exposure to the two forms may enhance the neurotoxicity of either alone, an especially worrisome outcome for the developing brain. Because joint exposure is such a common occurrence, with assays in pregnant women indicating that the inorganic form accounts for more than 25% of mercury in blood, this project is designed to more clearly define the associated risks to brain development. Pregnant rats will be exposed concurrently to mercury vapor by inhalation and to methylmercury in drinking water. Neurobehavioral measures in the offspring will include schedule-controlled operant behavior to assess cognitive behavior, motivation, and memory; hindlimb splay as an assay for motor function; and locomotor activity, a common assay for neurobehavioral status. Mercury concentrations in offspring brains will also be measured. The research will proceed in stages. (1) Exposure levels will produce mild to moderate degrees of neurotoxicity and reliable dose-effect functions for each form by itself. (2 and 3) Here we determine if a specified concentration of vapor changes the dose-effect function for methylmercury and if a specified dose of methylmercury alters the concentration-effect function of mercury vapor. These results will be used to calculate, by Benchmark Dose modeling, vapor and methyl exposures inducing a 10% and 25% change in the neurotoxic indices. (4) The combined effects of these levels will be determined. The acquisition of these data offers a firm foundation for determining the risks to neurobehavioral development of concurrent exposures to both mercury species.
描述(由申请人提供):有关食用鱼类、牙科汞合金和疫苗中防腐剂的危害的报告引起了公众对汞暴露的担忧。尽管对这些担忧的科学支持可能很薄弱,但我们对汞神经毒性的理解仍然存在相当大的差距,特别是在不同物种的联合暴露方面,这是一种常见的情况。对健康危害最大的两种形式是甲基汞,存在于鱼类和海洋哺乳动物中,以及金属汞蒸气,存在于工业、化妆品和牙科汞合金中。机制分析和有限的实验数据表明,共同暴露于这两种形式可能会增强单独使用的神经毒性,这对发育中的大脑来说是一个特别令人担忧的结果。由于联合接触是一种常见的现象,孕妇的检测表明,无机形式的汞占血液中汞的25%以上,因此该项目旨在更清楚地确定对大脑发育的相关风险。孕鼠将同时通过吸入接触汞蒸气和饮用水中的甲基汞。后代的神经行为测量将包括时间表控制的操作行为,以评估认知行为,动机和记忆;后肢张开作为运动功能的测定;和运动活动,神经行为状态的常见测定。后代大脑中的汞浓度也将被测量。这项研究将分阶段进行。(1)接触水平将产生轻度至中度的神经毒性,并对每种形式本身产生可靠的剂量效应函数。(2和3)在这里,我们确定了特定浓度的蒸汽是否改变了甲基汞的剂量效应函数,以及特定剂量的甲基汞是否改变了汞蒸汽的浓度效应函数。这些结果将用于通过基准剂量建模计算导致神经毒性指数变化10%和25%的蒸汽和甲基暴露。(4)将确定这些水平的综合影响。这些数据的获得为确定同时接触两种汞对神经行为发育的风险提供了坚实的基础。

项目成果

期刊论文数量(0)
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Bernard Weiss其他文献

Bernard Weiss的其他文献

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{{ truncateString('Bernard Weiss', 18)}}的其他基金

Developmental Neurotoxicity of Phthalate Esters
邻苯二甲酸酯的发育神经毒性
  • 批准号:
    7462274
  • 财政年份:
    2007
  • 资助金额:
    $ 35.97万
  • 项目类别:
Developmental Neurotoxicity of Phthalate Esters
邻苯二甲酸酯的发育神经毒性
  • 批准号:
    7235956
  • 财政年份:
    2007
  • 资助金额:
    $ 35.97万
  • 项目类别:
Neurotoxic Interactions of Different Forms of Mercury
不同形式汞的神经毒性相互作用
  • 批准号:
    7276766
  • 财政年份:
    2005
  • 资助金额:
    $ 35.97万
  • 项目类别:
Neurotoxic Interactions of Different Forms of Mercury
不同形式汞的神经毒性相互作用
  • 批准号:
    6814590
  • 财政年份:
    2005
  • 资助金额:
    $ 35.97万
  • 项目类别:
LATENT CONSEQUENCES OF DEVELOPMENTAL NEUROTOXICITY
发育神经毒性的潜在后果
  • 批准号:
    6106057
  • 财政年份:
    1999
  • 资助金额:
    $ 35.97万
  • 项目类别:
LATENT CONSEQUENCES OF DEVELOPMENTAL NEUROTOXICITY
发育神经毒性的潜在后果
  • 批准号:
    6366957
  • 财政年份:
    1999
  • 资助金额:
    $ 35.97万
  • 项目类别:
DEVELOPMENTAL NEUROTOXICITY OF METALLIC MERCURY
金属汞的发育神经毒性
  • 批准号:
    2882843
  • 财政年份:
    1998
  • 资助金额:
    $ 35.97万
  • 项目类别:
LATENT CONSEQUENCES OF DEVELOPMENTAL NEUROTOXICITY
发育神经毒性的潜在后果
  • 批准号:
    6270954
  • 财政年份:
    1998
  • 资助金额:
    $ 35.97万
  • 项目类别:
NEUROBEHAVIORAL CONSEQUENCES OF PRENATAL TCDD EXPOSURE
产前 TCDD 暴露的神经行为后果
  • 批准号:
    2636295
  • 财政年份:
    1998
  • 资助金额:
    $ 35.97万
  • 项目类别:
NEUROBEHAVIORAL CONSEQUENCES OF PRENATAL TCDD EXPOSURE
产前 TCDD 暴露的神经行为后果
  • 批准号:
    6017013
  • 财政年份:
    1998
  • 资助金额:
    $ 35.97万
  • 项目类别:

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