Generation of protective immunity against severe influenza disease in Indigenous Australians

澳大利亚原住民对严重流感疾病的保护性免疫力的产生

• 批准号: nhmrc : 1122524
• 负责人: A/Pr Stephanie Gras
• 金额: $ 111.35万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/generation-protective-immunity-indigenous-australians/946978
• 关键词: Generation; protective; immunity; against; severe

Hospitalisation and death rates from influenza are high in the Indigenous population, especially when a new virus emerges. There is an urgent need for a vaccine that protects against all influenza strains. T cells recognising conserved viral regions elicit such protection. As T cells are restricted by proteins called HLAs, which vary across ethnicities, we will define T cell regions for HLAs prominent in Indigenous Australians and define how to generate protective immunity against influenza.

在土著人口中，流感的住院率和死亡率很高，特别是在出现新病毒时。目前迫切需要一种能预防所有流感毒株的疫苗。识别保守病毒区域的T细胞引发了这种保护。由于T细胞受到hla蛋白的限制，而hla蛋白因种族而异，因此我们将确定澳大利亚原住民中突出的hla的T细胞区域，并确定如何产生针对流感的保护性免疫。