A molecular investigation into lipid-reactive immunity to combat Mycobacterium tuberculosis infection

对抗结核分枝杆菌感染的脂质反应免疫的分子研究

• 批准号: nhmrc : GNT1128924
• 负责人: A/Pr Stephanie Gras
• 金额: $ 62.82万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-investigation-lipid-tuberculosis-infection/1347722
• 关键词: molecular; investigation; into; lipid; reactive

Tuberculosis (TB) infection currently causes ~1.5 million deaths annually. Due to new survival features acquired by the causative agent (Mycobacterium tuberculosis), traditional TB drugs and vaccines are becoming inefficient. Mycobacterium tuberculosis has a protective lipid-dense cell wall that is targeted by our immune system. We aim to understand the mechanisms of the lipid-mediated immune response to TB in order to develop more effective strategies to combat this disease.

结核病感染目前每年造成约150万人死亡。由于病原体(结核分枝杆菌)获得了新的生存特征，传统的结核病药物和疫苗正变得效率低下。结核分枝杆菌有一层保护性的致密脂质细胞壁，是我们免疫系统的靶标。我们的目标是了解结核病脂质介导的免疫反应的机制，以开发更有效的策略来抗击这种疾病。