Time Domian Electron Paramagnetic Resonance Imaging

时域电子顺磁共振成像

• 批准号: 7292182
• 负责人: murali cherukuri
• 金额: --
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7292182
• 关键词: Time; Domian; Electron; Paramagnetic; Resonance

Project 1: Time Domian Electron Paramagnetic Resonance Imaging:Summary:a) Instrumentation: We have developed instrumentation to with data acquisition modalities utilizing "Time-locked sub sampling" strategies. This modality uses low speed data acquisition ( 20 - 100 MHz) to sample high-speed transient data without loss of integrity of the signal quality. The advantage of this modality is that low-cost signal averagers with better dynamic range can be utilized in imaging. Specifically, in imaging experiments, the dynamic range of the image intensity will be significantly improved so that low intensity pixels will be validly represented even in the presence of high intensity regions.b) Digital EPR imaging spectrometer: Until now the EPR imaging instrumentation utilized spectrometers using analog modules. With the recent availability of digital signal processing technology (DSP), we have initiated the implementation of digital version of the EPR Imaging spectrometer. The specific advantages of this effort are that significant reduction in time of image data collection/reconstruction as well as elimination of noise contributions associated with analog components. We completed a test platform and successfully implemented a DSP based EPR imaging spectrometer.c) Graphic User Interface: Since the EPR Imaging spectrometer is an NIH built research spectrometer; the operation of the scanner is fairly complicated and also can be damaged by users unfamiliar with instrumentation. Since most in vivo experiments are carried out by members of the lab with minimal experience with instrumentation, we have developed a graphics user interface (GUI) to make the operation of the scanner for data collection user friendly as well as an additional interface for image reconstruction and display.

项目一：时域电子顺磁共振成像：概述：a）仪器：我们已经开发了仪器，以利用“时间锁定子采样”策略进行数据采集。该模式使用低速数据采集（20 - 100 MHz）对高速瞬态数据进行采样，而不会损失信号质量的完整性。这种方式的优点是，低成本的信号平均器具有更好的动态范围可以在成像中使用。具体地，在成像实验中，图像强度的动态范围将被显著地改善，使得即使在存在高强度区域的情况下，低强度像素也将被有效地表示。B）数字EPR成像光谱仪：到目前为止，EPR成像仪器利用使用模拟模块的光谱仪。随着数字信号处理技术（DSP）的最新发展，我们已经开始实施EPR成像光谱仪的数字版本。这一努力的具体优点是，显着减少图像数据采集/重建的时间，以及消除与模拟组件相关的噪声贡献。我们完成了一个测试平台，并成功地实现了基于DSP的EPR成像光谱仪。c）图形用户界面：由于EPR成像光谱仪是NIH建造的研究光谱仪;扫描仪的操作相当复杂，也可能被不熟悉仪器的用户损坏。由于大多数体内实验是由实验室成员进行的，他们对仪器的经验很少，因此我们开发了一个图形用户界面（GUI），使扫描仪的数据收集操作对用户友好，以及图像重建和显示的附加界面。