Overhauser Enhanced Magnetic Resonance Imaging (OMRI)

a）在肿瘤血管渗透性和氧合方面使用体内分析肿瘤 低场水的超极化。超极化通常是用 顺磁性分子TAM。从图像强度分布，我们获得了肿瘤氧和 肿瘤血管通透性同时与免疫组化 肿瘤的特征。我们发现，肿瘤缺氧与肿瘤细胞的增殖有关， 血管通透性，这反过来又与血管周细胞覆盖率呈负相关。 B）监测超极化（离体）13 C-标记的甘草酸的体内分解产物 在肿瘤中：在这项研究中，我们注射了13 C标记的丙酮酸，并监测了转化为 乳酸盐丙酮酸/乳酸比在肿瘤中定量，并与氧相关。 从EPRI获得的肿瘤图。

a) Profile tumors in terms of tumor vascular permeability and oxygenation using in vivo hyperpolarization of water at low fields. Hyperpolarization is usually carried out with the paramagnetic molecule TAM. From the image intensity profiles we obtained tumor oxygen and tumor vascular permeability simultaneously and correlated with immunohistochemical characterization of tumors. We found that tumor hypoxia was associated with increased tumor vascular permeability which in turn was negatively correlated with vascular pericyte coverage. b) Monitor the in vivo breakdown products of hyperpolarized (ex vivo) 13C-labeled pyruvic acid in tumors: In this study, we injected 13C labeled pyruvate and monitored the conversion to lactate. The pyruvate/lactate ratio was quantified in the tumor and correlated with oxygen maps from the tumor obtained from EPRI.