GENERATION OF VASCULARISED, BIOENGINEERED SOFT TISSUES
生成血管化生物工程软组织
基本信息
- 批准号:nhmrc : 145782
- 负责人:
- 金额:$ 29.68万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:NHMRC Project Grants
- 财政年份:2001
- 资助国家:澳大利亚
- 起止时间:2001-01-01 至 2003-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
One of the most exciting areas in reconstructive surgery today is the tissue engineering of body parts, the process by which blood vessels are implanted into skin, muscle, bone, cartilage or even synthetic materials, to build composite living structures. Once a circulation becomes established, the engineered part can be transferred by joining the implanted blood vessels to corresponding ones at the recipient site. We have discovered that new tissue will grow out of a surgically created blood vessel loop placed in a cylindrical plastic chamber filled with a scaffold made of naturally occurring structural molecules. In Part 1 of this project, it is planned to optimise the rate of new vascularised tissue growth through the addition to the growth chamber of various biodegradable scaffolds. In Part 2, we aim to produce fat by 3 possible methods using: (a) cells from the rat scrotum, (b) skeletal muscle separated from its blood supply for 24 hours, or (c) bone marrow-derived stem cells, as well as bone from stem cells of the same source. In Part 3, vascularised bone, fat and connective tissue, as produced in Part 2, will be microsurgically transferred to another site in the body to study the short-term (4 weeks) and long-term (12 weeks) survival and changes (if any) in these tissues. These unique methods are currently being patented. This technology introduces the possibility of producing tailor-made tissues of specific composition to suit the repair of a particular tissue type, for example, (1) myocutaneous flaps to replace tissue loss following traumatic injury, (2) bone for nose, digit or joint repair, and (3) fat to provide a bulky flap as required in contour defects of the face and neck. The development of new growth chambers of appropriate body shapes (eg. ears, noses, etc) has significant commercial implications.
当今重建手术中最令人兴奋的领域之一是身体部位的组织工程,即将血管植入皮肤,肌肉,骨骼,软骨甚至合成材料中以构建复合生物结构的过程。一旦建立了循环,就可以通过将植入的血管连接到受体部位的相应血管来转移工程部分。我们已经发现,新的组织将从手术创建的血管环中生长出来,该血管环放置在一个圆柱形塑料腔室中,该腔室充满了由天然结构分子制成的支架。在该项目的第1部分中,计划通过向生长室添加各种可生物降解支架来优化新血管化组织生长的速率。在第2部分中,我们的目标是通过3种可能的方法产生脂肪:(a)来自大鼠阴囊的细胞,(B)从其血液供应中分离24小时的骨骼肌,或(c)骨髓来源的干细胞,以及来自相同来源的干细胞的骨。在第3部分中,将第2部分中产生的血管化骨、脂肪和结缔组织通过显微手术转移到体内的另一个部位,以研究这些组织的短期(4周)和长期(12周)存活率和变化(如有)。这些独特的方法目前正在申请专利。该技术引入了生产特定组成的定制组织以适合特定组织类型的修复的可能性,例如,(1)肌皮瓣以替代创伤性损伤后的组织损失,(2)用于鼻、手指或关节修复的骨,以及(3)脂肪以提供面部和颈部轮廓缺陷所需的大块皮瓣。发展适当体型的新生长室(例如,耳朵、鼻子等)具有重要的商业意义。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Aurora Messina其他文献
Requirements for obtaining unbiased estimates of neuronal numbers in frozen sections
获得冰冻切片中神经元数量无偏估计的要求
- DOI:
10.1016/s0165-0270(00)00177-1 - 发表时间:
2000 - 期刊:
- 影响因子:3
- 作者:
Aurora Messina;C.L.C Sangster;Wayne A. Morrison;Mary P. Galea - 通讯作者:
Mary P. Galea
The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles
肥大细胞和纤维类型在小鼠骨骼肌缺血再灌注损伤中的作用
- DOI:
- 发表时间:
2004 - 期刊:
- 影响因子:0
- 作者:
S. Bortolotto;Wayne A. Morrison;Aurora Messina - 通讯作者:
Aurora Messina
Morphometric analysis of peripheral nerves in people with spinal cord injury
脊髓损伤患者外周神经的形态计量学分析
- DOI:
10.1038/s41598-025-07809-6 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:3.900
- 作者:
Aurora Messina;Mary P. Galea - 通讯作者:
Mary P. Galea
Aurora Messina的其他文献
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{{ truncateString('Aurora Messina', 18)}}的其他基金
In vivo tissue engineering of adipose tissue for reconstructive surgery
用于重建手术的脂肪组织体内组织工程
- 批准号:
nhmrc : 299872 - 财政年份:2004
- 资助金额:
$ 29.68万 - 项目类别:
NHMRC Project Grants
Engineering tissues and organs in vivo from stem cells
用干细胞在体内改造组织和器官
- 批准号:
nhmrc : 209045 - 财政年份:2002
- 资助金额:
$ 29.68万 - 项目类别:
NHMRC Project Grants
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