Imaging Hippocampal Function in Psychosis

精神病中海马功能的成像

• 批准号: 7225906
• 负责人: STEPHAN HECKERS
• 金额: $ 24.71万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-07 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7225906
• 关键词: Affect; Amygdaloid structure; Area; Autopsy; Award; Bipolar Disorder; Brain; Brain region; Chronic; Chronic Schizophrenia; Cognitive deficits; Complement; Development; Episodic memory; Functional Imaging; Functional disorder; Grant; Hippocampal Formation; Hippocampus (Brain); Hospitalization; Image; Learning; Magnetic Resonance Imaging; Medial; Memory; Memory impairment; Mentored Clinical Oncology Award; Mentored Clinical Scientist Award; Mentored Patient-Oriented Research Career Development Award; Parietal Lobe; Pathology; Patients; Prefrontal Cortex; Production; Protocols documentation; Psychotic Disorders; Research Design; Research Personnel; Resolution; Risk; Role; Schizophrenia; Staging; Structure; Symptoms; Task Performances; Temporal Lobe; Testing; Thalamic structure; Thick; Time; base; experience; functional disability; memory retrieval; neuroimaging; novel; paired stimuli; programs; relating to nervous system; relational memory

DESCRIPTION (provided by applicant): This is a revised proposal to study the structure and function of the hippocampal formation in psychosis. Hippocampal volume deficits are among the most robust brain abnormalities in chronic patients with schizophrenia. More recent studies have now established that hippocampal volume reduction is already present in the early stages of psychosis - in patients who develop schizophrenia as well as those who develop bipolar disorder. It is unclear, however, whether hippocampal pathology can explain the psychotic features or the well-known memory deficits in schizophrenia and bipolar disorder. Here the applicant is proposing to test the hypothesis that hippocampal dysfunction is necessary (but not sufficient) for the production of psychosis. Memory deficits are predicted to be prominent in schizophrenia and bipolar disorder because cortico-hippocampal interactions are perturbed in psychosis. To test this hypothesis, two groups of patients will be studied with novel morphometric and functional imaging approaches. First, two forms of hippocampal-dependent memory (i.e., the ability to remember episodes and the ability to infer relationships among items) will be studied in chronic patients with schizophrenia. This will allow the applicant to test the prediction that hippocampal dysfunction in conjunction with cortical and thalamic abnormalities can explain specific memory deficits in schizophrenia. Second, schizophrenic and bipolar patients will be studied at the time of their first hospitalization. Hippocampal function during episodic and relational memory task performance is predicted to be abnormal in the early stages of psychosis, whereas cortical dysfunction is less prominent compared to chronic patients with schizophrenia. The proposed studies are designed to elucidate the crucial role of hippocampal dysfunction for the production of psychosis and the development of cognitive deficits in schizophrenia and bipolar disorder.

描述（由申请人提供）：这是一个修订后的建议，以研究精神病海马结构的结构和功能。海马体积缺陷是慢性精神分裂症患者最明显的脑异常之一。最近的研究已经证实，海马体积减少已经存在于精神病的早期阶段-在精神分裂症患者和双相情感障碍患者中。然而，海马病理学是否能解释精神分裂症和双相情感障碍的精神病特征或众所周知的记忆缺陷尚不清楚。 在此，申请人提出检验海马功能障碍对于精神病的产生是必要的（但不是充分的）这一假设。记忆缺陷被预测为精神分裂症和双相情感障碍的突出，因为皮质-海马相互作用在精神病中受到干扰。为了验证这一假设，将采用新的形态测量和功能成像方法对两组患者进行研究。首先，两种形式的依赖于记忆的记忆（即，记忆事件的能力和推断项目之间关系的能力）将在患有精神分裂症的慢性患者中进行研究。这将允许申请人测试海马功能障碍与皮质和丘脑异常结合可以解释精神分裂症中特定记忆缺陷的预测。其次，精神分裂症和双相情感障碍患者将在首次住院时进行研究。海马功能在情节和关系记忆任务的性能被预测为异常的精神病的早期阶段，而皮质功能障碍是不太突出的慢性精神分裂症患者相比。 这些研究旨在阐明海马功能障碍在精神分裂症和双相情感障碍中产生精神病和认知缺陷的关键作用。