Thesis title Enantioselective Chalcogen Bonding Catalysis

论文题目 对映选择性硫属键合催化

• 批准号: 2883873
• 金额: --
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2883873
• 关键词: Thesis; title; Enantioselective; Chalcogen; Bonding

Microorganisms produce siderophores for acquisition and storage of iron. In fungi, the majority of siderophore compounds produced belong to the hydroxamate class. This chemical functionality originates from L-ornithine, which is N5-hydroxylated and subsequently N5-acylated to yield a bidentate ligand. Recent work has elucidated the molecular programming of the non-ribosomal peptide synthetase (NRPS) enzyme responsible for the biosynthesis of ferrichrome, a cyclic hexapeptide siderophore. This NRPS offers the exciting potential to produce derivatives of the ferrichrome scaffold through chemical synthesis and mutagenesis of the enzymatic domains. This project aims to exploit the flexibility of the NRPS to introduce different peptidyl backbones, and biorthogonal handles for derivatisation. Novel compounds have potential uses as antibiotics and in medical imaging.

微生物产生铁载体用于获取和储存铁。在真菌中，产生的大多数铁载体化合物属于异羟肟酸类。该化学官能团源自L-鸟氨酸，其被N5-羟基化，随后被N5-酰化以产生双齿配体。最近的工作已经阐明了非核糖体肽合成酶（NRPS）的分子编程负责铁色素，一个环状六肽铁载体的生物合成。这种NRPS提供了令人兴奋的潜力，通过化学合成和诱变的酶结构域产生衍生物的铁色素支架。该项目旨在利用NRPS的灵活性，引入不同的肽基主链和双正交手柄进行衍生化。新化合物具有作为抗生素和医学成像的潜在用途。