CORE--DATA MANAGEMENT AND ANALYSIS CORE

一项执行良好的研究产生的数据最终将得出临床推论。适当的数据管理和适当的分析技术是整个研究的重要组成部分，以确保做出有效的推断。HRCA/哈佛Reasonable疗养院数据管理和分析核心的目标是在数据管理和分析的所有阶段提供领导，包括研究规划和设计、实施、数据分析以及项目内所有研究的手稿准备。核心人员的主要职责是提供数据管理、数据库编程、研究设计和采样以及统计分析方面的专业知识。核心小组的具体目标如下： 1.收集和管理在筛选和个别项目进行期间从受试者获得的纵向信息数据库 2.在研究设计的所有阶段与流行病学核心和调查顾问合作，包括确定研究的抽样方案，确定观察结果的不相等概率选择的加权调整，以及解释观察结果的聚类、分层和无应答。 3.为项目研究者提供方法和分析方面的专业知识，包括研究设计、实施、数据分析、解释和手稿准备。 为了实现这些目标，核心成员将在每个拟议项目的规划和评估的各个方面进行持续合作。核心小组还将与核心工作人员不断互动，以确保程序的一致性和效率。该核心是一种资源，拥有适当的最先进的软件和数据收集程序方面的专门知识，将能够管理和分析这些项目产生的数据。

A well-executed study generates data from which clinical inferences will ultimately be drawn. The proper management of data and appropriate analytic techniques are essential components of the overall study to ensure that valid inferences will be made. The goals of the HRCA/Harvard Reasearch Nursing Home Data Management and Analysis Core are to provide leadership in all phases of data management and analyses encompassing study planning and design, implementation, data analysis and the preparation of manuscripts for all studies within the project. The primary responsibilities of the Core will be to provide expertise in the areas of data management, database programming, study design and sampling, and statistical analyses. Specific aims of the Core are as follows: 1. To assemble and manage a database of longitudinal information obtained from the subjects during screening and during the conduct of individual projects 2. To collaborate with the Epidemiology Core and the survey consultant in all phases of study design including determining the sampling scheme for the study, determining the weighting adjustments for unequal probability selection of observations, and accounting for the clustering of observations, stratification, and nonresponse. 3. To provide methodological and analytic expertise to project investigators including study design, conduct, data analysis, interpretation and manuscript preparation. To achieve these goals, the members of the Core will have ongoing collaboration in all aspects of the planning and evaluation of each of the proposed projects. The Core will also have continuous interaction with core staff to ensure the consistency and efficiency of procedures. The Core is a resource that has appropriate state-of-the-art software and expertise in data collection procedures that will enable the management and analysis of the data that result from these projects.