CORE--DATA MANAGEMENT AND ANALYSIS CORE

一项执行良好的研究产生的数据最终将得出临床推论。数据的适当管理和适当的分析技术是整个研究的基本组成部分，以确保做出有效的推断。HRCA/哈佛研究养老院数据管理和分析核心的目标是在数据管理和分析的所有阶段提供领导，包括研究规划和设计、实施、数据分析和为项目内所有研究准备手稿。核心的主要责任将是在数据管理、数据库编程、研究设计和抽样以及统计分析等领域提供专门知识。核心计划的具体目标如下： 1.收集和管理在筛选和实施个别项目期间从受试者那里获得的纵向信息的数据库 2.在研究设计的所有阶段与流行病学核心和调查顾问合作，包括确定研究的抽样方案，确定不等概率选择观察的权重调整，并考虑观察、分层和无反应的聚集。 3.向项目调查员提供方法和分析方面的专门知识，包括研究设计、实施、数据分析、口译和手稿编写。 为实现这些目标，核心成员将在每个拟议项目的规划和评价的所有方面不断开展合作。核心还将与核心工作人员持续互动，以确保程序的一致性和效率。核心是一种资源，它拥有适当的最先进的软件和数据收集程序方面的专门知识，将能够管理和分析这些项目产生的数据。

A well-executed study generates data from which clinical inferences will ultimately be drawn. The proper management of data and appropriate analytic techniques are essential components of the overall study to ensure that valid inferences will be made. The goals of the HRCA/Harvard Reasearch Nursing Home Data Management and Analysis Core are to provide leadership in all phases of data management and analyses encompassing study planning and design, implementation, data analysis and the preparation of manuscripts for all studies within the project. The primary responsibilities of the Core will be to provide expertise in the areas of data management, database programming, study design and sampling, and statistical analyses. Specific aims of the Core are as follows: 1. To assemble and manage a database of longitudinal information obtained from the subjects during screening and during the conduct of individual projects 2. To collaborate with the Epidemiology Core and the survey consultant in all phases of study design including determining the sampling scheme for the study, determining the weighting adjustments for unequal probability selection of observations, and accounting for the clustering of observations, stratification, and nonresponse. 3. To provide methodological and analytic expertise to project investigators including study design, conduct, data analysis, interpretation and manuscript preparation. To achieve these goals, the members of the Core will have ongoing collaboration in all aspects of the planning and evaluation of each of the proposed projects. The Core will also have continuous interaction with core staff to ensure the consistency and efficiency of procedures. The Core is a resource that has appropriate state-of-the-art software and expertise in data collection procedures that will enable the management and analysis of the data that result from these projects.