Biostatistics and Data Management (BDM) Core - Urban ARCH Consortium

生物统计和数据管理 (BDM) 核心 - Urban ARCH 联盟

• 批准号: 8210499
• 负责人: DEBBIE M. CHENG
• 金额: $ 54.94万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8210499
• 关键词: AIDS/HIV problem; Address; Adherence; Alcohol consumption; Alcohols; Behavioral; Biological Markers; Biometry; Boston; Clinical; Clinical Research; Clinical Trials; Clinical Trials Data Monitoring Committees; Cohort Studies; Collaborations; Collection; Confidentiality; Data; Data Analyses; Data Collection; Data Protection; Data Quality; Data Security; Databases; Development; Disease; Disease Outcome; Disease Progression; Double-Blind Method; Ensure; Epidemiologic Studies; Equipment and supply inventories; Evaluation; Future; Goals; HIV; Human Resources; Individual; Inflammatory; Information Technology; International; Internet; Intervention; Intervention Studies; Leadership; Longitudinal Studies; Manuscripts; Monitor; Online Systems; Outcome; Participant; Patients; Performance; Persons; Pharmacotherapy; Phase; Play; Preparation; Principal Investigator; Process; Productivity; Protocols documentation; Publications; Quality Control; Randomized Clinical Trials; Recording of previous events; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Resources; Role; Russia; Sampling; Site; Specimen; Statistical Methods; Summary Reports; System; Techniques; Testing; Time; Uganda; Work; abstracting; alcohol consequences; alcohol research; bone health; cohort; data management; design; experience; follow-up; high standard; improved; instrument; member; programs; prospective; protocol development; repository; research study; sound

DESCRIPTION (provided by applicant): A sound study design, appropriate analytic techniques, and the proper management of data are essential components of a study to ensure that valid inferences will be made. The Biostatistics and Data Management (BDM) Core within the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium will provide statistical and data management leadership in all phases of research including study design, development of data collection instruments, implementation of the study protocols, performance of data analyses, and the preparation of manuscripts. The BDM Core will actively collaborate in the design, conduct, and analyses of clinical research studies with the aim of conducting scientifically rigorous research and providing definitive answers to the important scientific questions described within each project-specific proposal. There are two principal objectives of the BDM Core: to provide active statistical collaboration in the design and analysis of each individual study; and to develop and maintain an integrated, centralized data management system that may be used by all studies within the URBAN ARCH Consortium. To accomplish these goals, the BDM Core will have ongoing collaboration in all aspects of the planning, execution, and evaluation of each of the URBAN ARCH Consortium projects. The BDM Core brings together a highly experienced team of investigators who have collaborated extensively in studies of alcohol use and HIV, and who have a history of international, multi-site collaboration. Within the BDM Core, a close interaction of personnel performing tasks will facilitate procedural consistency and efficiency of Consortium-wide systems. Ultimately, the BDM Core will increase the productivity of the Consortium investigators, ensure the validity and generalizability of the research findings generated from the URBAN ARCH Consortium, and elevate the scientific understanding of alcohol's impact on HIV disease outcomes. PUBLIC HEALTH RELEVANCE: The Biostatistics and Data Management Core will collaborate extensively with URBAN ARCH Consortium investigators in all phases of study, from study inception to the publication of research findings. These activities will contribute to the efforts of each study to examine the consequences of alcohol on HIV disease by increasing the efficiency and productivity of Consortium investigators and ultimately ensuring the scientific integrity of results from the URBAN ARCH Consortium studies.

描述(由申请人提供)：合理的研究设计、适当的分析技术和适当的数据管理是研究的基本组成部分，以确保做出有效的推断。乌干达、俄罗斯、波士顿酒精研究网络关于艾滋病毒/艾滋病的合作(城市ARCH)联盟内的生物统计和数据管理核心将在研究的所有阶段提供统计和数据管理方面的领导，包括研究设计、数据收集工具的开发、研究方案的执行、数据分析的执行和手稿的准备。BDM核心将积极合作设计、实施和分析临床研究研究，目的是进行科学严谨的研究，并为每个项目具体建议中描述的重要科学问题提供明确的答案。业务数据管理核心有两个主要目标：在每项单独研究的设计和分析方面提供积极的统计协作；开发和维护一个可供城市ARCH联盟内的所有研究使用的综合、集中的数据管理系统。为了实现这些目标，BDM核心将在每个城市ARCH联合体项目的规划、执行和评估的各个方面进行持续的合作。BDM核心汇集了一支经验丰富的调查团队，他们在酒精使用和艾滋病毒的研究中进行了广泛的合作，并有国际多地点合作的历史。在业务流程管理核心内，执行任务的人员之间的密切互动将促进整个联合体系统的程序一致性和效率。最终，BDM核心将提高联盟调查人员的生产力，确保城市ARCH联盟产生的研究结果的有效性和普适性，并提高对酒精对艾滋病毒疾病结果影响的科学理解。 公共卫生相关性：生物统计和数据管理核心将在研究的所有阶段，从研究开始到研究结果的发表，与城市ARCH联盟的调查人员广泛合作。这些活动将通过提高协会调查人员的效率和生产力，并最终确保城市ARCH协会研究结果的科学完整性，促进每项研究检查酒精对艾滋病毒疾病的后果。