Biostatistics and Data Management (BDM) Core - Urban ARCH Consortium

描述（由申请人提供）：健全的研究设计，适当的分析技术和适当的数据管理是研究的基本组成部分，以确保将做出有效的推论。乌干达-俄罗斯-波士顿酒精网络关于艾滋病毒/艾滋病的酒精研究合作（URBAN ARCH）联盟内的生物统计和数据管理（BDM）核心将在研究的所有阶段提供统计和数据管理领导，包括研究设计、数据收集工具的开发、研究方案的实施、数据分析的执行和手稿的编写。BDM核心将积极参与临床研究的设计、实施和分析，目的是进行科学严谨的研究，并为每个项目具体提案中描述的重要科学问题提供明确的答案。BDM核心有两个主要目标：在每项研究的设计和分析中提供积极的统计合作；并开发和维护一个集成的、集中的数据管理系统，供URBAN ARCH联盟内的所有研究使用。为了实现这些目标，BDM核心将在URBAN ARCH联盟每个项目的规划、执行和评估的各个方面进行持续的合作。BDM核心汇集了一个经验丰富的调查人员团队，他们在酒精使用和艾滋病毒研究方面进行了广泛合作，并具有国际多地点合作的历史。在BDM核心中，执行任务的人员之间的密切互动将促进整个联盟系统的程序一致性和效率。最终，BDM核心将提高联盟研究人员的生产力，确保URBAN ARCH联盟产生的研究结果的有效性和普遍性，并提高对酒精对艾滋病毒疾病结果影响的科学理解。

DESCRIPTION (provided by applicant): A sound study design, appropriate analytic techniques, and the proper management of data are essential components of a study to ensure that valid inferences will be made. The Biostatistics and Data Management (BDM) Core within the Uganda Russia Boston Alcohol Network for Alcohol Research Collaboration on HIV/AIDS (URBAN ARCH) Consortium will provide statistical and data management leadership in all phases of research including study design, development of data collection instruments, implementation of the study protocols, performance of data analyses, and the preparation of manuscripts. The BDM Core will actively collaborate in the design, conduct, and analyses of clinical research studies with the aim of conducting scientifically rigorous research and providing definitive answers to the important scientific questions described within each project-specific proposal. There are two principal objectives of the BDM Core: to provide active statistical collaboration in the design and analysis of each individual study; and to develop and maintain an integrated, centralized data management system that may be used by all studies within the URBAN ARCH Consortium. To accomplish these goals, the BDM Core will have ongoing collaboration in all aspects of the planning, execution, and evaluation of each of the URBAN ARCH Consortium projects. The BDM Core brings together a highly experienced team of investigators who have collaborated extensively in studies of alcohol use and HIV, and who have a history of international, multi-site collaboration. Within the BDM Core, a close interaction of personnel performing tasks will facilitate procedural consistency and efficiency of Consortium-wide systems. Ultimately, the BDM Core will increase the productivity of the Consortium investigators, ensure the validity and generalizability of the research findings generated from the URBAN ARCH Consortium, and elevate the scientific understanding of alcohol's impact on HIV disease outcomes. PUBLIC HEALTH RELEVANCE: The Biostatistics and Data Management Core will collaborate extensively with URBAN ARCH Consortium investigators in all phases of study, from study inception to the publication of research findings. These activities will contribute to the efforts of each study to examine the consequences of alcohol on HIV disease by increasing the efficiency and productivity of Consortium investigators and ultimately ensuring the scientific integrity of results from the URBAN ARCH Consortium studies.