Exploring the role of RuBisCo binding domains in algal carbon fixation

Rubisco是地球上最重要的蛋白质之一，催化植物和藻类二氧化碳固定转化的第一步。如果我们要利用这种酶来应对气候变化和粮食短缺，了解Rubisco的生物化学是必不可少的。因此，在这个高度跨学科的项目中，我们将利用我们在合成化学和化学生物学方面的专业知识，对Rubisco生物化学的一个目前知之甚少的方面-控制Rubisco组装中物理化学保守但无序的结合结构域的作用-获得前所未有的了解。

Rubisco is one of the most important proteins on the planet, catalysing the first step in the conversion of carbon dioxide fixation in plants and algae. Understanding the biochemistry of Rubisco is essential if we are to harness this enzyme in the fight against climate change and food shortage. In this highly interdisciplinary project, we will therefore exploit our expertise in synthetic chemistry and chemical biology to gain unprecedented understanding of a currently poorly understood aspect of Rubisco biochemistry - the role of physicochemically conserved, yet disordered binding domains in controlling Rubisco assembly.