easuring the wear of a new, all-polymer PEEK-OPTIMA femoral knee component for total knee replacement

减轻全膝关节置换术中新型全聚合物 PEEK-OPTIMA 股骨膝关节组件的磨损

• 批准号: 2885506
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2885506
• 关键词: easuring; wear; new; polymer; PEEK

One in 5 total knee replacement patients receiving a conventional metal-on-polyethylene implant report dissatisfaction with their prosthesis. One potential reason for this dissatisfaction relates to the materials from which the joint is manufactured. The cobalt chrome femoral component is heavy, has a high modulus, low thermal conductivity and the potential to release metal ions. To address these issues, Invibio Limited have developed a novel all polymer knee replacement solution, comprising PEEK-OPTIMA femoral component coupled with an all-polyethylene tibial component. The advancement of such musculoskeletal interventions such as joint replacements is essential to the ageing population and aims to provide better quality of life, bring high standard affordable healthcare to a larger market whilst tackling national and global healthcare issues. Prior to clinical adoption of new medical devices, the functional performance under a wide envelope of clinically relevant conditions replicating those the knee will be subjected to in the body should be investigated. In particular, understanding the tribology of the knee replacement is important to predict its longevity in vivo. In this material combination, it can no longer be assumed that wear will be constrained to the UHMWPE tibial insert, and it will be critical to understand whether wear of the femoral PEEK component will occur. Currently, methods to assess the wear of the femoral component are limited, and compounded by material considerations in this case such as moisture uptake by the PEEK material. The focus of this PhD research will therefore be the development and validation of new measurement methods to determine the wear of the PEEK femoral component.

接受传统金属对聚乙烯植入物的膝关节置换术患者中，每5人中就有1人对假体感到不满意。这种不满的一个潜在原因与制造接头的材料有关。钴铬股骨组件重量大，模数高，导热系数低，具有释放金属离子的潜力。为了解决这些问题，Invibio Limited开发了一种新型的全聚合物膝关节置换解决方案，包括PEEK-OPTIMA股骨假体和全聚乙烯胫骨假体。推进这种肌肉骨骼干预措施，如关节置换，对老龄化人口至关重要，旨在提供更好的生活质量，为更大的市场提供高标准、负担得起的医疗保健，同时解决国家和全球医疗保健问题。在临床采用新的医疗设备之前，应该研究在广泛的临床相关条件下的功能表现，这些条件复制了膝关节在体内将受到的影响。特别是，了解膝关节置换的摩擦学对于预测其在体内的寿命非常重要。在这种材料组合中，不能再假设磨损将仅限于UHMWPE胫骨植入件，了解股骨PEEK组件是否会发生磨损将是至关重要的。目前，评估股骨假体磨损的方法有限，在这种情况下，还需要考虑材料因素，如PEEK材料的吸湿性。因此，PHD研究的重点将是开发和验证新的测量方法，以确定PEEK股骨假体的磨损。