Genetic determinants of antigenic escape in malaria parasites

该项目旨在了解疟疾寄生虫如何逃避免疫反应，这对疫苗和诊断测试的开发至关重要。利用自然感染疟疾的人的样本，我们将分析他们的免疫反应和他们感染的菌株，以了解寄生虫需要哪些突变才能反复感染他们的宿主。该项目的主要成果将是设计更有效的疟疾干预措施的系统。

This project aims to understand how malaria parasites to evade immune responses, which is critical for development of vaccines and diagnostic tests. Using samples from people who are naturally infected with malaria, we will analyse their immune responses and the strains they are infected with to understand what mutations are required for parasites to repeatedly infect their hosts. The major outcome of this project will be a system for designing more effective malaria interventions.