Bone Sparing Effects of Soy Phytoestrogens in Menopause

女性一生中将有三分之一的时间处于更年期。长期雌激素缺乏的并发症 在更年期是很确定的。尽管激素替代疗法(HRT)可以节省 妇女健康倡议的调查结果表明，这些并发症中的一些具有巨大的潜力 健康风险，促使越来越多的女性从处方药HRT转向非处方药的风险 产品希望大豆中的植物雌激素和其他来自天然来源的“雌激素”可以取代 处方雌激素的好处，同时避免严重的副作用。尽管有相当广泛的 而现在使用迅速增长的植物雌激素，很大程度上还是我们对S的长期了解 有效性和安全性。我们建议进行“大豆植物雌激素作为替代雌激素(备用)”。 对年轻更年期妇女使用纯净大豆进行为期2年的疗效评估的研究 异黄酮类预防骨质流失。我们的研究还将探索口服异黄酮类药物对小鼠的疗效。 预防更年期症状和其他与雌激素缺乏相关的变化。这项研究将 描述一种特定的大豆异黄酮制剂在人体内的作用，并将这些作用联系起来 与循环血清中主要异黄酮代谢物的水平，提供了新的洞察其长期的 术语生物行为。这项为期5年的研究将提供有关更年期的知识基础 女性可以开始对激素替代疗法和更年期体征和症状做出更明智的决定。

Women will live a third of their lives in menopause. The complications of prolonged estrogen deficiency during the menopausal years are well established. Although hormone replacement therapy (HRT) can spare women some of these complications, the Women's Health Initiative findings indicate significant potential health risks, risks that prompt more and more women to turn from prescribed HRT to over-the-counter products in the hope that soy phytoestrogens and other "estrogens" from natural sources can replace prescription estrogens in terms of benefits while sparing critical side effects. In spite of the fairly widespread and now rapidly growing use o f phyto estrogens, maj or gap s remain in our knowledge o f their long-term efficacy and safety. We propose to conduct a "Soy Phytoestrogens As Replacement Estrogen (SPARE)" study in young menopausal women to evaluate the effectiveness of a 2-year treatment with purified soy isoflavones in preventing bone loss. Our study will also explore the effectiveness of oral isoflavones in preventing menopausal symptoms and other changes associated with estrogen deficiency. The study will characterize the actions of a defined preparation of soy isoflavones in humans and will correlate these actions with the circulating serum levels of the principal isoflavone metabolites, providing new insights on their long- term biological actions. This 5-year study will provide a foundation of knowledge from which menopausal women can begin to make more informed decisions regarding HRT and menopausal signs and symptoms.