Vitamin D in Vulnerable Adults

描述（由申请人提供）： 项目概要/摘要：维生素D缺乏症（LoD，血清25羟维生素D水平低于32 ng/ml）由于其不仅与骨丢失和骨折有关，而且与影响老年人的几乎所有主要疾病和综合征有关，已成为老年人的主要关注点。研究LoD和维生素D补充剂的关键目标人群是社区居住的独立老年人中快速增长的久坐人群，他们的LoD患病率最高，身体残疾和虚弱的脆弱性增加。这些人可能对增加身体活动的生活方式改变有很强的抵抗力。最近的几项研究表明，补充维生素D可提高久坐不动的老年人的体能，从而延缓或防止他们的衰退和残疾。 我们已发表的和初步的研究记录了LoD是南佛罗里达的一个主要问题，特别是在老年男性退伍军人群体中，并证明了使用大剂量但安全的维生素D进行维生素D稳健补充的可行性。与我们在评估老年人身体表现方面的专业知识相一致，这些研究为随机临床试验开辟了道路，以确定是否在患有LoD的久坐老年男性退伍军人中补充大量维生素D将提高执行维持独立所需的体力任务的能力。 久坐的男性退伍军人，年龄在65至90岁之间，将参加我们的VIVA-VA研究（VA中脆弱成人的维生素D），这是一项双盲，安慰剂对照，随机临床试验，旨在确定维生素D的强力补充是否可以改善短期身体表现电池（SPPB）测试的身体表现。

DESCRIPTION (provided by applicant): Project Summary/Abstract: Hypovitaminosis D (LoD, serum 25 hydroxyvitamin D levels below 32 ng/ml) has become a major concern for an aging population by virtue of its association not only with bone loss and fractures but also with virtually all major diseases and syndromes affecting aging persons. The key target population for studying LoD and vitamin D supplementation is the rapidly growing sedentary segment of community-dwelling independent elderly persons who have the greatest prevalence of LoD and increased vulnerability for physical disability and frailty. Such persons can be highly resistant to lifestyle changes that would increase their physical activity. Several recent studies suggest that vitamin D supplementation would enhance physical performance in sedentary older persons and thereby delay or prevent their decline and disability. Our published and preliminary studies document LoD as a major problem in south Florida, particularly in the older male veteran population, and demonstrate the feasibility of robust supplementation with vitamin D using large, but safe, doses of vitamin D. In concert with our expertise in assessing physical performance in older persons, these studies open the way to a randomized clinical trial to ascertain whether robust vitamin D supplementation in sedentary older male veterans with LoD will improve the ability to perform physical tasks needed for maintaining independence. Sedentary male veterans, ages 65 to 90, will be enrolled in our VIVA-VA Study (VitaminD In Vulnerable Adults in the VA), a double-blind, placebo-controlled, randomized clinical trial aimed at ascertaining whether robust supplementation with vitamin D improves physical performance as tested by the Short Physical Performance Battery (SPPB).