Electrode Array for Bloodless Liver Resection

用于无血肝脏切除的电极阵列

• 批准号: 7271698
• 负责人: James Arthur Will
• 金额: $ 9.99万
• 依托单位: MEDICAL ENGINEERING INNOVATIONS, LLC
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-24 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7271698
• 关键词: Ablation; Affect; Anesthesia procedures; Animal Model; Animals; Area; Bile fluid; Biological Preservation; Blood Pressure; Blood Transfusion; Caliber; Clinical; Coagulation Process; Complication; Devices; Disseminated Malignant Neoplasm; Electrodes; Engineering; Equilibrium; Excision; Family suidae; Frequencies; Goals; Gold; Hemorrhage; Hepatectomy; Hour; Kidney; Laboratories; Length of Stay; Liver; Malignant neoplasm of liver; Measures; Medical; Medical Research; Methods; Monitor; Morbidity - disease rate; Normal tissue morphology; Operative Surgical Procedures; Patients; Performance; Postoperative Period; Procedures; Radio; Radiofrequency Interstitial Ablation; Rate; Resected; Series; Shapes; Site; Slice; Standards of Weights and Measures; Techniques; Time; Tissues; biliary tract; cancer therapy; concept; day; in vivo; innovation; microwave electromagnetic radiation; outcome forecast; prototype; radiofrequency; research study; size; tissue trauma; tumor

DESCRIPTION (provided by applicant): Both primary and metastatic liver cancer is common in the US, and worldwide. The standard treatment for liver cancer is liver resection, where part of the liver containing the tumor is surgically removed. This operation is associated with considerable blood loss, typically between 0.6 - 1 L. Blood loss is adversely associated with patient morbidity and survival, particularly when blood transfusions are required. We have developed a device that allows coagulation of a plane of liver tissue within 3 minutes, including major vessels. The device consists of a linear array of electrodes, to which radiofrequency (RF) energy is applied in bipolar fashion between neighboring electrodes. With our laboratory prototype we were able to coagulate a tissue slice in vivo in porcine liver, including all vessels (up to 4.3 mm in diameter), and subsequently resect along the coagulated slice with negligible bleeding. This device has the potential of reducing blood loss during liver resection surgery to a minimum, with likely increase in patient survival and lowered complication rates. In this proposal we plan use our current laboratory prototype to investigate three different electrode sizes. We will determine the ideal electrode configuration in terms of required performance while limiting tissue trauma due to electrode insertion. We will then show feasibility of our prototype in an animal survival study, where we perform liver resection with our device in five animals. The animals will be monitored for four days after surgery, and any post-operative internal bleeding will be determined.

描述（由申请人提供）：原发性和转移性肝癌在美国和世界范围内都很常见。肝癌的标准治疗是肝切除术，其中包含肿瘤的部分肝脏被手术切除。该手术伴随大量失血，通常在0.6 - 1 L之间。失血与患者的发病率和生存率有不良关系，特别是在需要输血时。我们开发了一种设备，可以在3分钟内凝固一个平面的肝脏组织，包括主要血管。该器械由线性电极阵列组成，在相邻电极之间以双极方式向其施加射频（RF）能量。使用我们的实验室原型，我们能够在猪肝中体内凝固组织切片，包括所有血管（直径最大为4.3 mm），随后沿凝固切片沿着切除，出血可忽略不计。该器械有可能将肝切除手术期间的失血量降至最低，可能增加患者生存率并降低并发症发生率。在本提案中，我们计划使用我们目前的实验室原型来研究三种不同的电极尺寸。我们将根据所需性能确定理想的电极配置，同时限制电极插入引起的组织创伤。然后，我们将在动物生存研究中展示我们的原型的可行性，在该研究中，我们在五只动物中使用我们的设备进行肝切除。手术后将对动物进行4天监测，并确定任何术后内出血。