Non-intrusive Locomotion and Gait Stability Analysis Monitoring System for the El

描述（由申请人提供）：该提案是SBIR第I阶段研究，旨在确定用于高级运动分析的创新性新设备的设计和可行性，包括：截肢评估和跌倒预防、姿势扰动评估和活动评估。它充分响应了NIA在2006年综合征求中确定为高度优先的主题领域，特别是老年医学和临床老年学方案。拟议的设备将是一个不显眼的，低功耗的无线设备，连接在手腕（类似于手表）。它将包括一个传感器套件，包括评估和选择小型陀螺仪，加速度计，压电和新型机电传感器设备，并能够将捕获的数据无线传输到远程服务器进行高级运动分析。使用特定的专利和测试算法，该系统将能够为用户提供以下信息的监测个人：1.截肢评估和跌倒预防-该系统将能够确定个人的基线截肢“足迹”，并确定是否存在需要干预的个人基线的任何重大偏差。该系统还将有算法来识别某些产生特征性步态异常的疾病状况，如帕金森病。目的是预防福尔斯，从而降低与跌倒损伤相关的发病率和死亡率。2.姿势紊乱-与Ambestry评估类似，该器械将表征个体的基线，并能够确定需要干预的基线的任何显著姿势偏离。同样，这将允许在个人福尔斯跌倒并遭受潜在的危及生命的伤害之前进行早期干预。3.活动评估-系统将能够确定个人的平均活动，并在与个人基线或预定基线存在任何显著偏差时发送警报。这个功能对于确定个体是否患有限制或夸大其活动的任何疾病过程至关重要。这一功能在研究和识别抑郁症或创伤后应激障碍等行为障碍方面特别有用。所提出的设备将是有用的，在该地区的老龄化研究，医疗保健门诊评估和长期的非侵入性监测老年人群的风险下降。该研究和由此产生的设备将提供以下益处：1.增强监测老年人健康和福祉的能力。2. 3.实现对高危人群的长期监测和早期干预AFrame开发了一种可穿戴、低功耗、形状友好、无线、基于手腕的设备原型，提供以下功能：（1）体温（2）脉搏血氧仪（3）心率和（4）位置信息。AFrame目前正在努力增加更多的生命体征功能，特别是（1）血压和（2）呼吸频率。如本提案所述，AFrame还致力于增加跌倒检测、步态分析、姿势扰动评估和活动评估。可穿戴设备可用于在短期或长期的基础上收集这些数据。设想的未来功能包括（1）无袖带血压（2）冲击计（3）激光脉搏血氧仪（AFrame顾问大卫戈德法布博士的专利技术）（4）血液化学（5）GPS或基于细胞的定位（E911）（6）非侵入性血糖监测仪。随着未来传感器或其他设备的开发，它们可以集成到AFrame创新的开放式健康监测系统中。该提案是与Thurmon Lockhart博士合作的。洛克哈特博士是弗吉尼亚理工学院和州立大学运动研究实验室的主任。AFrame将与Lockhart博士在第一阶段研究中密切合作，通过人体试验证明其可行性。该提案协同利用AFrame当前的技术和原型可穿戴设备来添加已被美国国家老龄化研究所确定为高优先级领域的功能。拟议的系统将具有强大的商业潜力，因为包括学术研究人员，医疗保健提供者和老年人护理机构在内的各种组织都需要密切监测他们的患者。该提案用于SBIR第一阶段研究，以确定用于高级运动分析的创新性新设备的设计和可行性，包括：截肢评估和跌倒预防，姿势扰动评估和活动评估。它充分响应了NIA在2006年综合征求中确定为高度优先的主题领域，特别是老年医学和临床老年学方案。拟议的设备将是一个不显眼的，低功耗的无线设备，连接在手腕（类似于手表）。它将包括一个传感器套件，包括评估和选择小型陀螺仪，加速度计，压电和新型机电传感器设备，并能够将捕获的数据无线传输到远程服务器进行高级运动分析。使用特定的专利和测试算法，该系统将能够为用户提供有关Amphibia评估，姿势扰动和活动评估的信息。与弗吉尼亚理工大学合作的人类受试者测试将在第一阶段进行，以证明可行性。

DESCRIPTION (provided by applicant): This proposal is for SBIR Phase I research to determine the design and feasibility of an innovative, new device for advanced locomotion analysis including: ambulation assessment and fall prevention, postural perturbation assessment and activity assessment. It is fully responsive to topic areas identified as high-priority by the NIA, specifically the Geriatrics and Clinical Gerontology Program, in the 2006 Omnibus Solicitation. The proposed device will be an unobtrusive, low-power, wireless device that attaches at the wrist (similar to a wrist watch). It will consist of a sensor suite including evaluation and selection of miniaturized gyroscope, accelerometer, piezoelectric and novel electro-mechanical sensor devices and be able to wirelessly transmit the captured data to a remote server for advanced locomotion analysis. Using specific patented and tested algorithms the system will be able to give the user the following information on a monitored individual: 1. Ambulation Assessment and Fall Prevention - the system will be able to determine an individual's baseline ambulation "footprint" and determine if there is any significant deviation from the individual's baseline requiring intervention. The system will also have algorithms to identify certain disease conditions that produce characteristic gait abnormalities such as Parkinson's disease. The goal is to prevent falls and thus reduce the morbidity and mortality associated with fall injuries. 2. Postural Perturbation - similar to ambulation assessment the device will characterize an individual's baseline and be able to determine any significant postural deviations from the baseline requiring intervention. Again, this will allow for early intervention, before the individual falls and suffers from a potentially life-threatening injury. 3. Activity Assessment - the system will be able to determine the average activity for an individual and send alerts if there is any significant deviation from the individual's baseline or deviation from a pre- determined baseline. This function will be vital to determine if the individual is suffering from any disease process limiting or exaggerating their activity. This function will be particularly useful in studying and identifying behavioral disorders such as depression or post-traumatic stress disorder. The proposed device will be useful in the area of aging research, for healthcare ambulatory assessment and for long-term unobtrusive monitoring of elderly populations at risk of falling. The research and resulting device will provide the following benefits: 1.Enhance the ability to monitor the health and well being of the elderly. 2.Enable further long and short term research in the elderly (and other) population 3.Enable the long-term monitoring and early intervention in high-risk populations AFrame has developed a prototype wearable, low-power, form-friendly, wireless, wrist-based device that provides the following functions: (1) Body Temperature (2) Pulse Oximetry (3) Heart Rate and (4) Location Information. AFrame is currently working to add further vital signs capability, specifically (1) Blood Pressure and (2) Respiratory Rate. As detailed in this proposal, AFrame is also working to add fall detection, gait analysis, postural perturbation assessment and activity assessment. The wearable device can be used to collect this data on a short or long-term basis. Future functions envisioned include (1) Cuff-less Blood Pressure (2) Shock Meter (3) Laser Pulse Oximetry (a technique patented by Dr. David Goldfarb, an AFrame adviser) (4) Blood Chemistries (5) GPS or Cell-Based Location (E911) (6) Non-Invasive Blood Glucose Monitor. As future sensors or other devices are developed they can be integrated into AFrame's innovative, open health monitoring system. This proposal is in collaboration with Dr. Thurmon Lockhart. Dr. Lockhart is the director of the Locomotion Research Laboratory at the Virginia Polytechnic Institute and State University. AFrame will be working closely with Dr. Lockhart in this Phase I research to demonstrate feasibility through human subjects testing. This proposal synergistically leverages AFrame's current technology and prototype wearable device to add functionality that has been identified as a high-priority area by the National Institute of Aging. The proposed system will have strong commercial potential given various organizations including academic researchers, healthcare providers and eldercare facilities have the need to closely monitor their patients. This proposal is for SBIR Phase I research to determine the design and feasibility of an innovative, new device for advanced locomotion analysis including: ambulation assessment and fall prevention, postural perturbation assessment and activity assessment. It is fully responsive to topic areas identified as high-priority by the NIA, specifically the Geriatrics and Clinical Gerontology Program, in the 2006 Omnibus Solicitation. The proposed device will be an unobtrusive, low-power, wireless device that attaches at the wrist (similar to a wrist watch). It will consist of a sensor suite including evaluation and selection of miniaturized gyroscope, accelerometer, piezoelectric and novel electro-mechanical sensor devices and be able to wirelessly transmit the captured data to a remote server for advanced locomotion analysis. Using specific patented and tested algorithms the system will be able to give the user information on ambulation assessment, postural perturbations and activity assessment. Human subjects testing in collaboration with Virginia Tech will be conducted during Phase I to demonstrate feasibility.