Development of a calcium-phosphate nanocomplex fluoride-based mouthrinse
磷酸钙纳米复合氟化物漱口水的开发
基本信息
- 批准号:7323901
- 负责人:
- 金额:$ 10万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2007
- 资助国家:美国
- 起止时间:2007-09-01 至 2008-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAgeArtsBraces-Orthopedic appliancesChemicalsDentalDental EnamelDental cariesDentitionDevelopmentDiseaseDrug FormulationsFluoridesGoalsHealth BenefitIncidenceInstitutesKineticsLesionMethodsMineralsModelingParticle SizePhasePopulationPrevention approachProcessPublic HealthPurposeResearchResearch ProposalsRiskSodium FluorideTechniquesTestingThermodynamicsTooth DiseasesWorkXerostomiabasecalcium phosphatecommercial applicationcommercializationcraniofacialdemineralizationimprovedinnovationnovelpreventprototyperemineralizationrestorationsolid statesuccesssurfactantuptake
项目摘要
DESCRIPTION (provided by applicant): Caries formation and progression is a disorder that affects nearly 80% of the U.S. population by age 17. While great success has been achieved in reducing caries incidence since the introduction of commercially available fluoride, opportunities for improving the current art are not just available, they are in great demand. Therefore, identification of novel materials that could work synergistically with fluoride to enhance remineralization and further prevent demineralization of the dentition could provide a tremendous public health benefit. Fluoride mouthrinses are a proven and favorable method of fluoride delivery, especially for high-risk caries groups including those wearing braces, those with xerostomia, and those with restorations. Therefore, the long-term goal of this research is to construct a single multi-mineral mouthrinse formulation that manifests stability between calcium-phosphate nanocomplexes and fluoride to provide increased levels of protection against caries than would be observed with fluoride alone. We posit these calcium-phosphate nanocomplexes can be formed through a mechanochemical ball milling technique and, as a result, are stable with fluoride. This well-known technique not only creates smaller particle sizes but also modifies the chemical signatures of the milling material, thus setting it distinctly apart from usual milling methods. In this Phase I research application to the NIDCR, we propose to address the following Specific Aims: 1) Synthesize numerous surfactant-calcium phosphate nanocomplexes entirely in the solid-state using a novel mechanochemical ball milling process that is readily scaleable for commercial applications; 2) Test the kinetic and thermodynamic stability of the nanocomplex when added to basic sodium fluoride mouthrinse formulations; and 3) Evaluate the remineralization efficacy of the most promising stable nanocomplex-fluoride mouthrinse formulations using pH cycling remineralization/demineralization models and enamel fluoride uptake studies.
描述(由申请人提供):龋齿形成和进展是一种影响近80%的美国人口的疾病。虽然自从引入市售氟化物以来,在降低龋齿发病率方面取得了巨大成功,但改进现有技术的机会不仅是可用的,而且需求量很大。因此,鉴定可以与氟化物协同作用以增强矿化并进一步防止牙列脱矿的新型材料可以提供巨大的公共健康益处。含氟漱口水是一种行之有效的氟化物输送方法,特别是对于高危龋齿人群,包括戴牙套的人,口腔干燥症患者和牙齿矫正患者。因此,本研究的长期目标是构建一种单一的多矿物质漱口液配方,该配方在磷酸钙纳米复合物和氟化物之间表现出稳定性,以提供比单独使用氟化物时更高水平的防龋保护。我们证实这些钙-磷酸盐纳米复合物可以通过机械化学球磨技术形成,因此,与氟化物稳定。这种众所周知的技术不仅可以产生更小的颗粒尺寸,而且还可以改变研磨材料的化学特征,从而使其与通常的研磨方法截然不同。在NIDCR的第一阶段研究应用中,我们提出了以下具体目标:1)使用一种新的机械化学球磨工艺完全以固态合成许多表面活性剂-磷酸钙纳米复合物,该工艺易于规模化用于商业应用; 2)测试纳米复合物在添加到碱性氟化钠漱口液制剂中时的动力学和热力学稳定性;和3)使用pH循环矿化/脱矿模型和牙釉质氟化物摄取研究来评估最有前景的稳定纳米复合物-氟化物漱口液制剂的矿化功效。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
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ROBERT L KARLINSEY其他文献
ROBERT L KARLINSEY的其他文献
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{{ truncateString('ROBERT L KARLINSEY', 18)}}的其他基金
Laboratory and clinical evaluation of prospective fluoride rinses containing TCP-
含有 TCP-的前瞻性氟化物冲洗液的实验室和临床评估
- 批准号:
8309858 - 财政年份:2011
- 资助金额:
$ 10万 - 项目类别:
Laboratory and clinical evaluation of prospective fluoride rinses containing TCP-
含有 TCP-的前瞻性氟化物冲洗液的实验室和临床评估
- 批准号:
7798356 - 财政年份:2011
- 资助金额:
$ 10万 - 项目类别:
Evaluation of a low-fluoride anticaries toothpaste containing an innovative calci
含有创新钙的低氟防龋牙膏的评价
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7924998 - 财政年份:2010
- 资助金额:
$ 10万 - 项目类别:
Development of a niobuim oxide as a potential coating for dental and orthopedic i
开发铌氧化物作为牙科和骨科的潜在涂层
- 批准号:
7597275 - 财政年份:2009
- 资助金额:
$ 10万 - 项目类别:
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