Development of a niobuim oxide as a potential coating for dental and orthopedic i

描述（由申请人提供）：预计到2010年，基于种植体的牙科产品的全球市场将接近35亿美元，尽管全球牙科市场中只有9%分配给牙科种植体，但它是增长最快的部分，每年增长15%。这些预测可能意味着，虽然在全球范围内观察到整体口腔健康的显着改善，但仍然存在与口腔修复设备相关的重大问题，包括多功能性，寿命和性能。更具体地说，与现有的牙科或骨科植入材料相关的一些常见故障包括无菌性松动、愈合时间长和生物活性涂层从植入物基材上分层。因此，通过桥接牙科、生物工程和材料科学领域，我们提出开发一种独特的植入物涂层，该涂层可以与现有的植入物基质协调发挥作用，以诱导快速的仿生过程，这可能会提供显着的公共健康益处。这项奋进的长期目标是开发一种独特的氧化铌涂层，该涂层与植入物基质形成牢固的界面结合，同时在体内植入高承载应用（如髋关节和牙齿置换）时刺激快速骨整合。我们假设这种纳米灵感的铌氧化物涂层表现出令人难以置信的生物活性，凭借其自组装的安排，通过快速氧化在水性电解质。所得氧化物由微米级锥体组成，这些锥体表现出适合磷灰石外延生长的晶体位点以及有利于细胞附着和生长的拓扑结构。在NIDCR的第1阶段研究提案中，我们提出了以下具体目标：1）在Ti6Al4V基材上沉积铌金属，然后进行光学和机械验证测量，2）通过划痕测试优化阳极氧化后的铌金属厚度，3）验证氧化铌微锥诱导的体内生物活性。 公共卫生相关性：预计到2010年，基于种植体的牙科产品的全球市场将接近35亿美元，尽管全球牙科市场中只有9%分配给牙科种植体，但它是增长最快的部分，每年增长15%。这些预测可能意味着，虽然在全球范围内观察到整体口腔健康的显着改善，但仍然存在与口腔修复设备相关的重大问题，包括多功能性，寿命和性能。这项奋进的长期目标是开发一种独特的氧化铌涂层，与植入物形成牢固的界面结合 当植入体内用于高承载应用（例如髋关节和牙齿置换）时，

DESCRIPTION (provided by applicant): The worldwide market for implant-based dental products is forecasted to approach $3.5 billion by 2010, and although only 9% of the global dental market is allocated to dental implants, it is the fastest growing segment at a rate of 15% per year. These projections could imply that although significant improvements in overall oral health are observed globally, there remains significant problems associated with prosthodontic devices, including versatility, longevity, and performance. More specifically, some common failures associated with existing implant materials, dental or orthopedic, include aseptic loosening, long healing times, and delamination of bioactive coatings from the implant substrate. Therefore, by bridging the fields of dentistry, bioengineering, and materials science we propose to develop a unique implant coating that could function in harmony with existing implant substrates to induce rapid biomimetic processes may provide a significant public health benefit. The long-term goal of this research endeavor is to develop a unique niobium oxide coating that forms strong interfacial bonds with the implant substrate while stimulating rapid osseointegration when implanted in vivo for high load-bearing applications, such as hip and tooth replacements. We hypothesize this nano-inspired niobium oxide coating exhibits incredible bioactivity by virtue of its self-assembled arrangement created through rapid oxidation in an aqueous electrolyte. The resulting oxide is comprised of micron-sized cones that manifest crystal sites amenable for epitaxial growth of apatite as well as topology that favors cellular attachment and growth. In this Phase 1 research proposal to the NIDCR, we propose to address the following specific aims:1) deposition of niobium metal onto Ti6Al4V substrates followed by optical and mechanical verification measurements, 2) optimizing niobium metal thickness after anodization via scratch tests, and 3) validation of niobium oxide microcone-induced bioactivity in vivo. PUBLIC HEALTH RELEVANCE: The worldwide market for implant-based dental products is forecasted to approach $3.5 billion by 2010, and although only 9% of the global dental market is allocated to dental implants, it is the fastest growing segment at a rate of 15% per year. These projections could imply that although significant improvements in overall oral health are observed globally, there remains significant problems associated with prosthodontic devices, including versatility, longevity, and performance. The long-term goal of this research endeavor is to develop a unique niobium oxide coating that forms strong interfacial bonds with the implant substrate while stimulating rapid osseointegration when implanted in vivo for high load-bearing applications, such as hip and tooth replacements.