MRI Biometry of the Pseudophakic Cadaver Eye

假晶状体尸眼的 MRI 生物测量

• 批准号: 7327826
• 负责人: SUSAN A STRENK
• 金额: $ 10万
• 依托单位: MRI RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7327826
• 关键词: Academia; Adverse effects; Age; Aging; Algorithms; Anatomy; Anterior; Astigmatism; Autopsy; Behavior; Biometry; Blood-Aqueous Barrier; Cadaver; Caliber; Calibration; Cataract; Cataract Extraction; Chronic; Ciliary Muscle; Complement; Complication; Computer software; Contact Lenses; Contrast Sensitivity; Corneal Endothelium; Crystalline Lens; Data; Data Collection; Databases; Depth; Development; Disruption; Educational process of instructing; Effectiveness; Endothelial Cells; Excision; Eye; Facility Construction Funding Category; Funding; Future; Glare; Glaucoma; Goals; Housing; Human; Hyperopia; Hyphema; Image; Imagery; In Situ; In Vitro; Industry; Intraocular Lens Implantation; Intraocular lens implant device; Invasive; Iris; Iritis; Joint Dislocation; Length; Magnetic Resonance Imaging; Marketing; Measurement; Mechanics; Methods; Modeling; Motivation; Myopia; Numbers; Operative Surgical Procedures; Optics; Outcome; Phase; Physiological; Placement; Positioning Attribute; Postoperative Complications; Postoperative Period; Presbyopia; Principal Investigator; Procedures; Pupil; Refractive Errors; Reporting; Resolution; Safety; Simulate; Small Business Funding Mechanisms; Small Business Innovation Research Grant; Standards of Weights and Measures; Structure; Techniques; Tissues; Uveitis; Vision; Visual Acuity; Work; anterior chamber; capsule; design; haptics; human data; improved; in vivo; interest; irritation; lens; models and simulation; optical imaging; programs; size; tool

DESCRIPTION (provided by applicant): Presbyopia is the loss of accommodation with age and industry efforts to provide surgical correction for presbyopia are vigorously underway as the potential market for such a product is substantial. Strategies include lens refilling, scleral treatments, and, most notably, the development of accommodating intraocular lenses (IOLs). However, despite this renewed interest in IOLs for the correction of presbyopia (as well as myopia, hyperopia, and astigmatism), results have been disappointing and many questions remain regarding the optic and haptic sizing and post-operative positional stability, development of Soemmering's ring and posterior capsule opacification (PCO), power calculations, and adverse effects of these and even established IOL designs. The high-resolution MRI techniques developed by the PI are not hampered by the iris and are thus able to provide non-invasive in-situ visualization of the entire IOL (optic and haptics) and its geometric relationship to surrounding intraocular structures; this information cannot be obtained by any other method. The ultimate goal of this study is to produce a biometric database of the unique information obtained from MRI images of both phakic and pseudophakic cadaver globes in order to fully characterize IOL placement in the anterior segment and to provide much needed calibration algorithms between our existing in vivo MRI biometry and cadaver biometry, since cadaver studies are routinely used in IOL design. Moreover, posterior capsule opacification is a common complication of cataract surgery that decreases visual acuity, has been correlated with IOL tilt and decentration, and is of particular concern with new IOL designs. Soemmering's ring, develops after virtually every IOL implantation, is a direct precursor to PCO, is associated with other complications including pupillary block glaucoma, and our preliminary data suggest that it is also closely associated with IOL malposition. We plan to develop methods of non-invasively grading Soemmering's ring in vitro with MRI and correlating Soemmering's ring in the pseudophakic cadaver globe with anterior segment biometry and IOL type, position, tilt, and decentration. Successful completion of this project will facilitate the construction of models that allow better pseudophakic, phakic, and accommodating IOL designs as well as other methods of presbyopia correction to be simulated and developed. Moreover, it will facilitate the construction of refined algorithms for preoperative IOL power calculations and improve our understanding of post-operative complications of IOL surgery. Cataract surgery is a common procedure that results in removal of the human lens and its replacement with an intraocular lens (IOL). It is a safe procedure, but complications do occur. Many new IOLs are being designed to further improve vision after cataract surgery; however, concerns exist regarding both the safety and effectiveness of these new designs. Magnetic resonance imaging has the unique ability to fully show the IOL position in the intact eye and will be used to study cadaver globes with IOLs in order to better understand the complications that can occur after IOL implantation and also to permit better and safer IOLs to be designed.

描述（由申请人提供）：老花眼是随着年龄增长而失去调节能力，由于此类产品的潜在市场巨大，因此正在大力开展为老花眼提供手术矫正的行业努力。策略包括透镜再填充、巩膜治疗，以及最显著的，可调节人工晶状体（IOL）的开发。然而，尽管人们重新对用于矫正老花眼（以及近视、远视和散光）的IOL产生了兴趣，但结果令人失望，关于光学部和支撑襻尺寸和术后位置稳定性、Soemmering环和后囊膜混浊（PCO）的发展、屈光度计算以及这些甚至已建立的IOL设计的不良反应，仍存在许多问题。PI开发的高分辨率MRI技术不受虹膜的阻碍，因此能够提供整个IOL（光学部和支撑部）及其与周围眼内结构的几何关系的无创原位可视化;该信息无法通过任何其他方法获得。本研究的最终目标是生成从有晶状体眼和人工晶状体眼尸体眼球的MRI图像中获得的唯一信息的生物特征数据库，以便充分表征眼前段中的IOL放置，并在我们现有的体内MRI生物特征和尸体生物特征之间提供急需的校准算法，因为尸体研究通常用于IOL设计。此外，后囊膜混浊是白内障手术的常见并发症，其降低视力，与IOL倾斜和偏心相关，并且特别关注新的IOL设计。Soemmering环是PCO的直接先兆，与其他并发症（包括瞳孔阻滞性青光眼）有关，我们的初步数据表明，它也与IOL错位密切相关。我们计划开发使用MRI在体外对Soemmering环进行无创分级的方法，并将人工晶状体尸体地球仪中的Soemmering环与前段生物测量和IOL类型、位置、倾斜和偏心相关联。该项目的成功完成将促进模型的构建，从而更好地模拟和开发人工晶状体、有晶状体眼和调节性IOL设计以及其他老视矫正方法。此外，它将有助于构建用于术前IOL屈光度计算的精细算法，并提高我们对IOL手术术后并发症的理解。白内障手术是导致人类透镜被移除并用眼内透镜（IOL）替换的常见手术。这是一个安全的过程，但并发症发生。许多新的IOL正在设计用于进一步改善白内障手术后的视力;然而，这些新设计的安全性和有效性存在问题。磁共振成像具有完全显示IOL在完整眼内位置的独特能力，并将用于研究装有IOL的尸体眼球，以更好地了解IOL植入后可能发生的并发症，并允许设计更好、更安全的IOL。

项目成果

Long-term pathological follow-up of obsolete design: Pannu universal intraocular lens.

过时设计的长期病理随访：Pannu通用人工晶状体。

• DOI: 10.1016/j.jcrs.2009.08.040
• 发表时间: 2010
• 期刊: Journal of cataract and refractive surgery
• 影响因子: 2.8
• 作者: Davis,Don;Werner,Liliana;Strenk,Susan;Strenk,Lawrence;Yeh,Oliver;Mamalis,Nick
• 通讯作者: Mamalis,Nick