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A DATABASE OF IOL POSITION AND BEHAVIOR

IOL 位置和行为数据库

基本信息

批准号：
6792843
负责人：
SUSAN A STRENK
金额：
$ 10万
依托单位：
MRI RESEARCH, INC.
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-09-30 至 2005-09-29
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant) The high-resolution MRI techniques developed by the Principal Investigator, offer unsurpassed image contrast, are non-invasive, permit the acquisition of images in any desired plane without obscuring vision, and provide undistorted in vivo visualization of the IOL/crystalline lens position in relation to the intraocular structures during accommodation and with accommodation at rest; this information cannot be obtained by any other method. The ultimate goal of this study is to produce a biometric database combining measurements obtained from MRI images and Scheimpflug images acquired from IOL patients and provide a detailed description of IOL placement and accommodative behavior in relation to the intraocular structures - including both successful and unsuccessful surgical outcomes from a variety of IOL types. The Phase I specific aims include: 1) collecting accommodative MRI data from the intact eye of cataract patients with monocular IOL implantation and measuring accommodative and age-related changes in the anterior segment anatomy; 2) collecting MRI corresponding data, from contralateral eye and measuring accommodative and age-related changes in both anterior segment anatomy and IOL position, tilt (in multiple planes) and decentration; and 3) combining the MR measurements obtained from the intact eye with our existing MR measurements and comparing these data with existing Scheimpflug data.

由首席研究员开发的高分辨率MRI技术，提供无与伦比的图像对比度，是非侵入性的，允许在任何期望的平面上获取图像而不会遮挡视力，并且在调节期间和调节休息时提供与眼内结构相关的IOL/晶状体位置的不扭曲的体内可视化；此信息不能通过任何其他方法获得。本研究的最终目标是建立一个生物特征数据库，结合从IOL患者获得的MRI图像和Scheimpflug图像获得的测量结果，并提供IOL放置和与眼内结构相关的调节行为的详细描述-包括各种IOL类型的成功和不成功的手术结果。第一阶段的具体目标包括：1)收集单眼人工晶状体植入术患者完整眼的适应性MRI数据，测量前段解剖结构的适应性和年龄相关变化；2)收集对侧眼的MRI相应数据，测量前节解剖结构和人工晶状体位置、倾斜（多平面）和分散的适应性和年龄相关变化；3)将完整眼的MR测量结果与我们现有的MR测量结果相结合，并将这些数据与现有的Scheimpflug数据进行比较。