Metallo-Supramolecular Materials for Chiral Discrimination and Enantiomeric Separation

用于手性辨别和对映体分离的金属超分子材料

• 批准号: FT140100273
• 负责人: Prof Jack Clegg
• 金额: $ 53.25万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-07-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT140100273
• 关键词: Metallo; Supramolecular; Materials; Chiral; Discrimination

Separating mixtures of molecules is one of the most enduring challenges in the chemical sciences and accounts for a significant cost burden in many industrial applications. This project aims to design and prepare new chiral self-assembled materials that contain cavities of predictable sizes and shapes. These materials, including molecular capsules, cages and network solids, will act to selectivity bind different chemical substrates within their chiral encapsulated spaces, thus enabling the straight-forward separation of racemic mixtures of molecules. Small molecules with enantiomeric purity are a fundamental requirement as starting materials for drug development and a wide range of pharmaceutical applications.

分离分子的混合物是化学科学中最持久的挑战之一，并且在许多工业应用中占显著的成本负担。该项目旨在设计和制备新型手性自组装材料，这些材料包含可预测尺寸和形状的空腔。这些材料，包括分子胶囊，笼和网络固体，将用于选择性结合不同的化学底物在其手性封装的空间，从而使分子的外消旋混合物的直接分离。具有对映体纯度的小分子是作为药物开发和广泛的制药应用的起始材料的基本要求。