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Developmental consequences of in utero cocaine

子宫内可卡因的发育后果

基本信息

批准号：
7216726
负责人：
BARBARA L THOMPSON
金额：
$ 5.13万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-03-01 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7216726
关键词：
Acute Adolescent Agonist Animal Model Animals Anterior Area Attention Attention Deficit Disorder Bathing Behavior Behavioral Biological Models Cells Cerebral cortex Child Clinical Clinical Research Cocaine Cognitive Complex Coupling Data Development Developmental Process Disruption Dopamine Dopamine Receptor Dose Employee Strikes Exhibits Fetal Cocaine Exposure Fire - disasters Functional disorder GTP-Binding Protein alpha Subunits Goals Human In Situ Interneurons Label Laboratories Left Localized Medial Mediating Membrane Potentials Modeling Molecular Neurons Norepinephrine Norepinephrine Receptors Numbers Oryctolagus cuniculus Outcome Parvalbumins Pattern Performance Phenotype Physiological Population Prefrontal Cortex Preparation Primates Property Receptor Signaling Research Design Research Personnel Rest Rodent Role Slice Structure System Testing Thinking Tissues behavior change behavioral pharmacology calbindin calretinin cingulate cortex critical developmental period design dopamine system functional outcomes gamma-Aminobutyric Acid in utero monoamine neurophysiology neurotransmission postnatal prenatal programs receptor receptor expression receptor function research study response species difference

项目摘要

DESCRIPTION (provided by applicant): Prenatal cocaine exposure during critical periods of development in rabbits selectively alters the structure of specific types of neurons and the coupling of the D1 dopamine (DA) receptor in DA-rich regions of the cerebral cortex, such as prefrontal and anterior cingulate cortices. Consistent with findings in this model system, children exposed to cocaine in utero exhibit a developmental phenotype that resembles attention deficit disorder. The specific expression patterns of the D1 receptor, changes in neurophysiological properties of cortical interneurons modulated by DA, and disrupted attention will be investigated in the rabbit model of in utero cocaine exposure. Pharmacological manipulations will establish a direct role of D1 receptor dysfunction in the poor performance on tasks that tap attention systems. Preliminary data suggest that in utero cocaine results in systems that function normally at baseline, but when the system is challenged, behavioral abnormalities emerge. Detailed characterization of the developmental consequences of prenatal cocaine exposure in this animal model will facilitate an understanding of the underlying molecular and cellular mechanisms that disrupt behavior in the clinical population.

描述（由申请人提供）：