UCD Mouse Biology Program: Pathology Resources Training and Cancer Modeling

描述（由申请人提供）：该候选人是一名解剖病理学家，在外科病理学和人类乳腺和前列腺诊断病理学方面受过高级培训；他的研究方向是癌症分子生物学和分子病理学。在过去的十年里，他在基因工程小鼠癌症模型的背景下研究了小鼠病理学。他是老鼠病理生物学的导师，教授医学和兽医病理学住院医师和研究员，研究生学位，医学和兽医学生。他曾担任多个国家和国际培训课程的教师。本奖项资助的指导计划包括：1)为已接受过病理学培训的MD或DVM候选人设立资助培训职位。2)为美国和加拿大病理学会年会开设小鼠特异性病理年度课程。3)利用全幻灯片图像/ Zoomify通信工具技术建立定期的小鼠癌症病理精神病理学会议。小鼠病理生物学研究的研究计划将建立在候选人实验室的资助工作基础上。重点是利用基因工程小鼠来了解癌症的基本机制。特别是，实验室已经表明，分离实验确定的具有异质组织病理学的乳腺癌前病变，揭示了预编码癌症进展的“茎样”行为。该计划需要1)开发分离技术和流式细胞术，用于分离小鼠癌前病变的特定细胞亚群。2)描述移植上皮细胞的组织病理学特征；3)分离并定义细胞亚群移植病理背景下的进展事件：a)癌前到侵袭和b)侵袭到转移。环境非常适合这个奖项的目标。在过去的十年里，加州大学戴维斯分校比较医学和小鼠生物学中心在小鼠病理生物学领域处于国际领先地位。相关声明：基因工程小鼠（GEM）已经成为模拟人类疾病的卓越生物。了解小鼠的病理生物学对这项事业的有效性和成功至关重要。发展人类疾病、小鼠生物学和遗传学综合领域的国家专业知识库是这项建议的主要目标。

DESCRIPTION (provided by applicant): The candidate is an anatomic pathologist with advanced training in surgical pathology and human breast and prostate diagnostic pathology; his research training is in cancer molecular biology and molecular pathology. He has studied mouse pathology in the context of genetically engineered mouse models of cancer for the past decade. He is a proven mentor in mouse pathobiology teaching medical and veterinary pathology residents and fellows, graduate degree, medical and veterinary students. He has served as teaching faculty in several national and international training courses. The plan for mentoring sponsored by this award includes: 1) Establishment of a funded training position for MD or DVM candidates with prior pathology training. 2) Development of an annual course on mouse specific pathology for the United States and Canadian Academy of Pathology Annual Meeting. And, 3) Establishment of a regular mouse cancer pathology telepathology conference using Whole Slide Image/ Zoomify Communications Tool technology. The research plan in mouse pathobiology research will build on funded work in the candidate's laboratory. The focus is on the use of genetically engineered mice to understand basic mechanisms of cancer. In particular, the laboratory has shown that isolation of experimentally defined mammary pre-cancer with heterogeneous histopathology reveals a "stem-like" behavior with pre-encoded cancer progression. The plan entails 1) Development of dissociation techniques and flow cytometry for isolation of specific cell subsets in mouse pre-cancers. 2) Characterize the histopathology of transplanted epithelial cells and 3) Isolate and define the progression events: a) pre-cancer to invasion and b) invasion to metastasis in the context of cell subset transplantation pathology. The environment is ideally suited to the objectives of this award. The UC Davis Center for Comparative Medicine and Mouse Biology Program has provided international leadership in the area of mouse pathobiology over the past decade. Relevance Statement: The genetically engineered mouse (GEM) has become the preeminent organism for modeling human disease. Understanding the pathobiology of the mouse is critical to the validity and success of this enterprise. Developing the national pool of expertise in the combined area of human disease, mouse biology and genetics is the primary objective of this proposal.