UCD Mouse Biology Program: Pathology Resources Training and Cancer Modeling

都柏林大学小鼠生物学项目：病理学资源培训和癌症建模

• 批准号: 7386197
• 负责人: ALEXANDER D BOROWSKY
• 金额: $ 13.5万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-26 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7386197
• 关键词: Academy; Anatomy; Animal Model; Area; Award; Behavior; Behavioral; Biological Models; Biology; Breast; Cancer Model; Carcinoma; Cell surface; Cells; Colon Carcinoma; Commit; Communication Tools; Development; Diagnostic; Disease; Dissociation; Educational process of instructing; Engineering; Environment; Epigenetic Process; Epithelial Cells; Epithelium; Evaluation; Event; Evolution; Faculty; Fatty acid glycerol esters; Flow Cytometry; Frequencies; Funding; Genetic; Genetically Engineered Mouse; Histopathology; Human; Human Pathology; Image; Immunophenotyping; Individual; International; Intraepithelial Neoplasia; Invasive; Laboratories; Leadership; Lesion; Malignant - descriptor; Malignant Neoplasms; Mammary Neoplasms; Mammary gland; Medical; Medicine; Mentors; Modeling; Molecular; Molecular Biology; Mus; Neoplasm Metastasis; Noninfiltrating Intraductal Carcinoma; Pathologist; Pathology; Population; Positioning Attribute; Property; Prostate; Research; Research Training; Resources; Slide; Staging; Stem cells; Students; Surgical Pathology; System; Techniques; Technology; Telepathology; Training; Transplantation; United States; Veterinary Pathology; Work; cancer cell; cancer stem cell; comparative; human disease; interest; malignant breast neoplasm; mammary epithelium; molecular pathology; mouse model; progenitor; programs; self-renewal; stem; success; symposium; tumor progression

DESCRIPTION (provided by applicant): The candidate is an anatomic pathologist with advanced training in surgical pathology and human breast and prostate diagnostic pathology; his research training is in cancer molecular biology and molecular pathology. He has studied mouse pathology in the context of genetically engineered mouse models of cancer for the past decade. He is a proven mentor in mouse pathobiology teaching medical and veterinary pathology residents and fellows, graduate degree, medical and veterinary students. He has served as teaching faculty in several national and international training courses. The plan for mentoring sponsored by this award includes: 1) Establishment of a funded training position for MD or DVM candidates with prior pathology training. 2) Development of an annual course on mouse specific pathology for the United States and Canadian Academy of Pathology Annual Meeting. And, 3) Establishment of a regular mouse cancer pathology telepathology conference using Whole Slide Image/ Zoomify Communications Tool technology. The research plan in mouse pathobiology research will build on funded work in the candidate's laboratory. The focus is on the use of genetically engineered mice to understand basic mechanisms of cancer. In particular, the laboratory has shown that isolation of experimentally defined mammary pre-cancer with heterogeneous histopathology reveals a "stem-like" behavior with pre-encoded cancer progression. The plan entails 1) Development of dissociation techniques and flow cytometry for isolation of specific cell subsets in mouse pre-cancers. 2) Characterize the histopathology of transplanted epithelial cells and 3) Isolate and define the progression events: a) pre-cancer to invasion and b) invasion to metastasis in the context of cell subset transplantation pathology. The environment is ideally suited to the objectives of this award. The UC Davis Center for Comparative Medicine and Mouse Biology Program has provided international leadership in the area of mouse pathobiology over the past decade. Relevance Statement: The genetically engineered mouse (GEM) has become the preeminent organism for modeling human disease. Understanding the pathobiology of the mouse is critical to the validity and success of this enterprise. Developing the national pool of expertise in the combined area of human disease, mouse biology and genetics is the primary objective of this proposal.

描述（由申请人提供）：候选人是一名解剖病理学家，接受过外科病理学以及人体乳腺和前列腺诊断病理学方面的高级培训；他的研究方向是癌症分子生物学和分子病理学。过去十年，他一直在基因工程小鼠癌症模型的背景下研究小鼠病理学。他是小鼠病理学领域公认的导师，教授医学和兽医病理学住院医生和研究员、研究生、医学和兽医学生。他曾在多个国内和国际培训课程中担任讲师。该奖项赞助的指导计划包括： 1) 为接受过病理学培训的 MD 或 DVM 候选人设立资助培训职位。 2) 为美国和加拿大病理学会年会开发小鼠特异性病理学年度课程。并且，3) 使用全幻灯片图像/ Zoomify 通信工具技术建立定期的小鼠癌症病理学远程病理学会议。小鼠病理生物学研究的研究计划将建立在候选人实验室资助的工作基础上。重点是利用基因工程小鼠来了解癌症的基本机制。特别是，该实验室已经表明，通过异质组织病理学分离实验定义的乳腺癌前病变，揭示了预先编码的癌症进展的“干细胞样”行为。该计划包括 1) 开发解离技术和流式细胞术，用于分离小鼠癌前病变中的特定细胞亚群。 2) 描述移植上皮细胞的组织病理学特征，3) 分离和定义进展事件：a) 癌前期到侵袭，b) 在细胞亚群移植病理学背景下从侵袭到转移。该环境非常适合该奖项的目标。加州大学戴维斯分校比较医学和小鼠生物学中心在过去十年中在小鼠病理学领域发挥了国际领导作用。相关性声明：基因工程小鼠 (GEM) 已成为模拟人类疾病的卓越生物体。了解小鼠的病理学对于该企业的有效性和成功至关重要。该提案的主要目标是发展人类疾病、小鼠生物学和遗传学联合领域的国家专业知识库。