UCD Mouse Biology Program: Pathology Resources Training and Cancer Modeling

应聘者描述(申请人提供)：应聘者是一名解剖病理学家，具有外科病理学和人类乳腺及前列腺诊断病理学方面的高级培训；他的研究培训是癌症分子生物学和分子病理学。在过去的十年里，他一直在基因工程小鼠癌症模型的背景下研究小鼠病理学。他是一位经验丰富的老鼠病理生物学导师，教授医学和兽医病理学住院医师和研究员、研究生学位、医学和兽医学生。他曾在多个国内和国际培训课程中担任教员。由该奖项赞助的指导计划包括：1)为曾接受过病理学培训的MD或DVM候选人设立一个资助的培训职位。2)为美国和加拿大病理学会年会制定关于小鼠特殊病理学的年度课程。3)利用全景图像/Zoomify通讯工具技术，建立常规的小鼠癌症病理远程病理会议。老鼠病理生物学研究的研究计划将建立在候选人实验室的资助工作基础上。重点是利用基因工程小鼠来了解癌症的基本机制。特别是，实验室已经表明，分离出具有不同组织病理学的实验定义的乳腺癌前病变，显示出具有预先编码的癌症进展的“干状”行为。该计划需要1)开发分离技术和流式细胞术，以分离小鼠癌症前期的特定细胞亚群。2)描述移植上皮细胞的组织病理学特征，3)分离和定义进展事件：a)癌前到侵袭，b)从细胞亚群移植病理学背景下的侵袭到转移。这个环境非常适合这个奖项的目标。加州大学戴维斯分校比较医学和老鼠生物学项目在过去十年中在老鼠病理生物学领域提供了国际领先地位。相关声明：基因工程小鼠(GEM)已成为模拟人类疾病的卓越生物。了解老鼠的病理生物学对于这项事业的有效性和成功至关重要。这项提议的主要目标是在人类疾病、小鼠生物学和遗传学的综合领域发展国家专业库。

DESCRIPTION (provided by applicant): The candidate is an anatomic pathologist with advanced training in surgical pathology and human breast and prostate diagnostic pathology; his research training is in cancer molecular biology and molecular pathology. He has studied mouse pathology in the context of genetically engineered mouse models of cancer for the past decade. He is a proven mentor in mouse pathobiology teaching medical and veterinary pathology residents and fellows, graduate degree, medical and veterinary students. He has served as teaching faculty in several national and international training courses. The plan for mentoring sponsored by this award includes: 1) Establishment of a funded training position for MD or DVM candidates with prior pathology training. 2) Development of an annual course on mouse specific pathology for the United States and Canadian Academy of Pathology Annual Meeting. And, 3) Establishment of a regular mouse cancer pathology telepathology conference using Whole Slide Image/ Zoomify Communications Tool technology. The research plan in mouse pathobiology research will build on funded work in the candidate's laboratory. The focus is on the use of genetically engineered mice to understand basic mechanisms of cancer. In particular, the laboratory has shown that isolation of experimentally defined mammary pre-cancer with heterogeneous histopathology reveals a "stem-like" behavior with pre-encoded cancer progression. The plan entails 1) Development of dissociation techniques and flow cytometry for isolation of specific cell subsets in mouse pre-cancers. 2) Characterize the histopathology of transplanted epithelial cells and 3) Isolate and define the progression events: a) pre-cancer to invasion and b) invasion to metastasis in the context of cell subset transplantation pathology. The environment is ideally suited to the objectives of this award. The UC Davis Center for Comparative Medicine and Mouse Biology Program has provided international leadership in the area of mouse pathobiology over the past decade. Relevance Statement: The genetically engineered mouse (GEM) has become the preeminent organism for modeling human disease. Understanding the pathobiology of the mouse is critical to the validity and success of this enterprise. Developing the national pool of expertise in the combined area of human disease, mouse biology and genetics is the primary objective of this proposal.