UCD Mouse Biology Program: Pathology Resources Training and Cancer Modeling

都柏林大学小鼠生物学项目：病理学资源培训和癌症建模

• 批准号: 8129605
• 负责人: ALEXANDER D BOROWSKY
• 金额: $ 15.19万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-26 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8129605
• 关键词: Academy; Anatomy; Animal Model; Area; Award; Behavior; Behavioral; Biological Models; Biology; Breast; Cancer Model; Carcinoma; Cell surface; Cells; Colon Carcinoma; Commit; Communication Tools; Development; Diagnostic; Disease; Dissociation; Educational process of instructing; Engineering; Environment; Epidemiology; Epigenetic Process; Epithelial Cells; Epithelium; Evaluation; Event; Evolution; Faculty; Fatty acid glycerol esters; Flow Cytometry; Frequencies; Funding; Genetic; Genetically Engineered Mouse; Histopathology; Human; Image; Immunophenotyping; Individual; International; Intraepithelial Neoplasia; Laboratories; Leadership; Lesion; Malignant - descriptor; Malignant Neoplasms; Mammary Neoplasms; Mammary gland; Medical; Medicine; Mentors; Modeling; Molecular; Molecular Biology; Mus; Neoplasm Metastasis; Noninfiltrating Intraductal Carcinoma; Pathologist; Pathology; Population; Positioning Attribute; Property; Prostate; Research; Research Training; Resources; Slide; Staging; Stem cells; Students; Surgical Pathology; System; Techniques; Technology; Telepathology; Training; Transplantation; United States; Veterinary Pathology; Work; cancer cell; cancer stem cell; comparative; human disease; interest; malignant breast neoplasm; mammary epithelium; meetings; molecular pathology; mouse model; progenitor; programs; self-renewal; stem; success; symposium; tumor progression

DESCRIPTION (provided by applicant): The candidate is an anatomic pathologist with advanced training in surgical pathology and human breast and prostate diagnostic pathology; his research training is in cancer molecular biology and molecular pathology. He has studied mouse pathology in the context of genetically engineered mouse models of cancer for the past decade. He is a proven mentor in mouse pathobiology teaching medical and veterinary pathology residents and fellows, graduate degree, medical and veterinary students. He has served as teaching faculty in several national and international training courses. The plan for mentoring sponsored by this award includes: 1) Establishment of a funded training position for MD or DVM candidates with prior pathology training. 2) Development of an annual course on mouse specific pathology for the United States and Canadian Academy of Pathology Annual Meeting. And, 3) Establishment of a regular mouse cancer pathology telepathology conference using Whole Slide Image/ Zoomify Communications Tool technology. The research plan in mouse pathobiology research will build on funded work in the candidate's laboratory. The focus is on the use of genetically engineered mice to understand basic mechanisms of cancer. In particular, the laboratory has shown that isolation of experimentally defined mammary pre-cancer with heterogeneous histopathology reveals a "stem-like" behavior with pre-encoded cancer progression. The plan entails 1) Development of dissociation techniques and flow cytometry for isolation of specific cell subsets in mouse pre-cancers. 2) Characterize the histopathology of transplanted epithelial cells and 3) Isolate and define the progression events: a) pre-cancer to invasion and b) invasion to metastasis in the context of cell subset transplantation pathology. The environment is ideally suited to the objectives of this award. The UC Davis Center for Comparative Medicine and Mouse Biology Program has provided international leadership in the area of mouse pathobiology over the past decade. Relevance Statement: The genetically engineered mouse (GEM) has become the preeminent organism for modeling human disease. Understanding the pathobiology of the mouse is critical to the validity and success of this enterprise. Developing the national pool of expertise in the combined area of human disease, mouse biology and genetics is the primary objective of this proposal.

描述（由申请人提供）：候选人是一名解剖病理学家，在外科病理学和人类乳腺和前列腺诊断病理学方面接受过高级培训;他的研究培训是癌症分子生物学和分子病理学。在过去的十年里，他在基因工程小鼠癌症模型的背景下研究了小鼠病理学。他是小鼠病理生物学教学医学和兽医病理学居民和研究员，研究生学位，医学和兽医学生证明导师。他曾在多个国家和国际培训课程中担任教员。该奖项赞助的指导计划包括：1）为以前接受过病理学培训的MD或DVM候选人建立一个资助的培训职位。2)为美国和加拿大病理学学会年会制定关于小鼠特异性病理学的年度课程。以及，3）使用全载玻片图像/ Zoomify通信工具技术建立定期的小鼠癌症病理学远程病理学会议。小鼠病理生物学研究的研究计划将建立在候选人实验室的资助工作基础上。重点是使用基因工程小鼠来了解癌症的基本机制。特别是，该实验室已经表明，分离具有异质性组织病理学的实验定义的乳腺癌前病变揭示了具有预编码癌症进展的“干细胞样”行为。该计划包括：1）开发解离技术和流式细胞术，用于分离小鼠癌前病变中的特定细胞亚群。2)表征移植的上皮细胞的组织病理学和3）分离和定义进展事件：a）在细胞亚群移植病理学的背景下癌前到侵袭和B）侵袭到转移。环境非常适合这个奖项的目标。加州大学戴维斯分校比较医学和小鼠生物学项目中心在过去十年中在小鼠病理生物学领域发挥了国际领导作用。相关性声明：基因工程小鼠（GEM）已成为人类疾病建模的杰出生物体。了解小鼠的病理生物学对这项事业的有效性和成功至关重要。本提案的主要目标是建立人类疾病、小鼠生物学和遗传学综合领域的国家专门知识库。

项目成果

Assessment of carprofen and buprenorphine on recovery of mice after surgical removal of the mammary fat pad.

评估卡洛芬和丁丙诺啡对手术切除乳腺脂肪垫后小鼠恢复的影响。

• 发表时间: 2010
• 期刊: Journal of the American Association for Laboratory Animal Science : JAALAS
• 作者: Adamson,TrinkaW;Kendall,LonV;Goss,Sherri;Grayson,Kevin;Touma,Chadi;Palme,Rupert;Chen,JaneQ;Borowsky,AlexanderD
• 通讯作者: Borowsky,AlexanderD

Redefining the expression and function of the inhibitor of differentiation 1 in mammary gland development.

重新定义分化抑制剂1在乳腺发育中的表达和功能。

• DOI: 10.1371/journal.pone.0011947
• 发表时间: 2010
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Nair,Radhika;Junankar,Simon;O'Toole,Sandra;Shah,Jaynish;Borowsky,AlexanderD;Bishop,JMichael;Swarbrick,Alexander
• 通讯作者: Swarbrick,Alexander