Chronobiology of cardiovascular and pulmonary disease

心血管和肺部疾病的时间生物学

• 批准号: 7232378
• 负责人: STEVEN A SHEA
• 金额: $ 12.87万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-20 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7232378
• 关键词: Arts; Asthma; Behavior; Behavioral; Biological Clocks; Biological Markers; Blood Vessels; Cardiovascular system; Chronobiology; Circadian Rhythms; Clinical; Clinical Investigator; Clinical Research; Data; Disease; Environment; Epidemiologic Studies; Event; Faculty; Funding; Goals; Hemostatic Agents; Hour; Laboratories; Lung; Lung diseases; Measures; Medical; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Modification; Neurobiology; Nocturnal Asthma; Outcome; Pattern; Phase; Physiologic Monitoring; Physiological; Posture; Protocols documentation; Research; Research Personnel; Risk Marker; Role; Schedule; Sleep; Sleep Disorders; Sleep Wake Cycle; Standards of Weights and Measures; Techniques; Time; Training Programs; United States National Institutes of Health; behavior influence; cardiovascular risk factor; circadian pacemaker; day; hemodynamics; improved; indexing; patient oriented research; programs; research facility; respiratory; stressor

DESCRIPTION (provided by applicant): The applicant has a funded research program in medical chronobiology, and is the Associate Director of an NIH funded Harvard-wide Training Program in Sleep, Circadian & Respiratory Neurobiology. He has a track record and commitment to mentoring clinical researchers. The candidate's immediate goal is to determine the physiological mechanisms underlying the robust day/night pattern in adverse cardiovascular events, and of nocturnal asthma. The long-term goal is to develop a group of outstanding clinical investigators studying complementary aspects of medical chronobiology. A K24 award will enable the applicant to realize these goals by enabling him to relinquish his clinical duties in a sleep disorders program and allowing more protected time for both patient-oriented research and mentoring of clinical research fellows. The environment for this research is outstanding, with over 50 successful research faculty involved with the Harvard-wide Division of Sleep Medicine. There are 'state of the art' research facilities, comprising intensive physiological monitoring suites in a General Clinical Research Center. The candidate has funding to determine the role of the body clock versus sleep in causing nocturnal asthma. The candidate plans to extend these studies in asthma, and to perform parallel studies into the mechanisms underlying the day-night pattern of adverse cardiovascular events, which has a large peak around 9 AM. To this end, a "Forced Desynchrony" protocol will be used, wherein subjects' behaviors occur at all phases of the circadian cycle. The aims are to determine the effect upon pulmonary and cardiovascular risk markers of (1) the intrinsic circadian rhythm (independent from behaviors); (2) the pattern in behavior related to the sleep-wake cycle, posture and activity (controlling for circadian phase); (3) any interaction. The biomarkers with potential relevance to cardiovascular vulnerability will include hemodynamic, hemostatic, autonomic and endothelial function measures. The applicant's longer-term goals will be to improve therapy in such disorders via modifications in behavior or chronopharmacology.

描述（由申请人提供）： 申请人在医学时间生物学方面有一个受资助的研究项目，并且是NIH资助的哈佛大学睡眠，昼夜节律和呼吸神经生物学培训项目的副主任。他有一个跟踪记录和承诺，指导临床研究人员。候选人的直接目标是确定不良心血管事件和夜间哮喘的强烈日/夜模式的生理机制。长期目标是培养一批优秀的临床研究人员，研究医学时间生物学的补充方面。K24奖项将使申请人能够放弃睡眠障碍项目中的临床职责，并为以患者为导向的研究和临床研究人员的指导提供更多受保护的时间，从而实现这些目标。这项研究的环境是杰出的，有超过50名成功的研究人员参与了哈佛大学睡眠医学部。有“最先进的”研究设施，包括在综合临床研究中心密集的生理监测套房。候选人有资金来确定生物钟与睡眠在引起夜间哮喘中的作用。候选人计划将这些研究扩展到哮喘，并对不良心血管事件的昼夜模式的机制进行平行研究，该模式在上午9点左右有一个大的峰值。为此，将使用“强制性强迫”方案，其中受试者的行为发生在昼夜节律周期的所有阶段。其目的是确定对肺和心血管风险标志物的影响：（1）内在昼夜节律（独立于行为）;（2）与睡眠-觉醒周期、姿势和活动相关的行为模式（控制昼夜节律相位）;（3）任何相互作用。与心血管脆弱性潜在相关的生物标志物将包括血流动力学、止血、自主神经和内皮功能指标。申请人的长期目标将是通过行为或时辰药理学的改变来改善此类疾病的治疗。