Renal blood flow,sodium handling and the DASH diet

肾血流量、钠处理和 DASH 饮食

• 批准号: 7175386
• 负责人: PAUL R CONLIN
• 金额: $ 14.95万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7175386
• 关键词: Acute; Adherence; Adrenal Glands; Affect; African American; Angiotensin II; Angiotensin Receptor; Angiotensinogen; Award; Biological; Blood; Blood Pressure; Blood Vessels; Carbohydrates; Cardiovascular Diseases; Cardiovascular Physiology; Clinical; Clinical Investigator; Clinical Sciences; Clinical Trials; Commit; Consensus; Dairy Products; Data; Diet; Dietary Factors; Dietary intake; Dyslipidemias; Educational process of instructing; Effectiveness; Employee Strikes; Endocrinology; Event; Excretory function; Expert Opinion; Faculty; Fat-Restricted Diet; Fatty acid glycerol esters; Funding; Future; Genotype; Goals; Grant; Guidelines; Hypertension; Hypotension; Individual; Kidney; LDL Cholesterol Lipoproteins; Life Style; Link; Lipids; Macronutrients Nutrition; Mentors; Mid-Career Clinical Scientist Award (K24); Modification; Patients; Pattern; Plasma; Population Study; Proteins; Public Health; Recruitment Activity; Renal Blood Flow; Renal Circulation; Renal function; Renin; Renin-Angiotensin System; Research; Research Personnel; Risk; Risk Factors; Sample Size; Sodium; Staging; Subgroup; Testing; Time; Tissues; Triglycerides; Vascular resistance; behavior influence; cardiovascular disorder risk; career; cost; design; feeding; follow-up; fruits and vegetables; improved; interest; kidney vascular structure; medical schools; nutrition; obesity risk; patient oriented research; pressure; prevent; programs; protective effect; response; saturated fat; treatment effect

DESCRIPTION (provided by applicant):This application for a K24 award is to provide support for Paul R. Conlin, MD to allow him protected time to devote to patient-oriented research and to act as a mentor for beginning clinical investigators. His long-term goal is to make significant contributions to the understanding of lifestyle modifications as they impact on renal and cardiovascular disease risk factors through clinical trials. Dr. Conlin has investigated the impact of dietary patterns and sodium on renal/adrenal function and cardiovascular disease risk factors. He was recently a collaborating investigator in the DASH (Dietary Approaches to Stop Hypertension) and DASH-Sodium studies, which showed that a low-fat diet enriched in fruits, vegetables and low-fat dairy products (DASH diet) either alone or with sodium restriction significantly lowered blood pressure. He is now studying the effect of three dietary patterns on renal and cardiovascular disease risk factors (blood pressure and lipid profile). This application proposes new specific aims in which he will study the effects of the DASH diet on the kidney- in particular, renal blood flow, renal vascular resistance and sodium excretion. These studies will test the hypotheses that the DASH diet vasodilates the renal vasculature and enhances sodium excretion in a manner that mimics ACE inhibition. These studies will be performed in individuals with high normal and Stage 1 hypertension, and subgroup analyses will be performed in African Americans. The results of these studies will reveal the added-value of the DASH diet on risk factors and protective effects on renal function in patients at risk for renal/cardiovascular disease. Dr. Conlin is fully committed to recruiting and mentoring junior clinical investigators destined for careers in patient-oriented research, particularly those interested in renal cardiovascular physiology, interventional nutrition or academic endocrinology, He has recently mentored 6 fellows and junior faculty, many of whom have achieved independent grant support. In addition, he will teach junior patient-oriented research investigators in the K30 funded "Scholars in Clinical Science" Program at Harvard Medical School. Thus, with the support of this award he will have significant impact on future patient-oriented research at multiple levels.

描述（由申请人提供）：本 K24 奖项申请旨在为医学博士 Paul R. Conlin 提供支持，让他有受保护的时间致力于以患者为导向的研究，并担任初级临床研究人员的导师。他的长期目标是通过临床试验为理解生活方式改变做出重大贡献，因为生活方式改变对肾脏和心血管疾病危险因素有影响。 Conlin 博士研究了饮食模式和钠对肾/肾上腺功能和心血管疾病危险因素的影响。他最近是 DASH（控制高血压的饮食方法）和 DASH-Sodium 研究的合作研究员，该研究表明，富含水果、蔬菜和低脂乳制品的低脂饮食（DASH 饮食）无论是单独使用还是限制钠摄入均可显着降低血压。他目前正在研究三种饮食模式对肾脏和心血管疾病危险因素（血压和血脂）的影响。该申请提出了新的具体目标，他将研究 DASH 饮食对肾脏的影响，特别是肾血流量、肾血管阻力和钠排泄。这些研究将检验以下假设：DASH 饮食以模拟 ACE 抑制的方式舒张肾脉管系统并增强钠排泄。这些研究将在正常高度高血压和 1 期高血压患者中进行，亚组分析将在非裔美国人中进行。这些研究的结果将揭示 DASH 饮食对危险因素的附加值以及对有肾脏/心血管疾病风险的患者肾功能的保护作用。 Conlin 博士完全致力于招募和指导初级临床研究人员，以从事以患者为导向的研究，特别是那些对肾心血管生理学、介入营养学或学术内分泌学感兴趣的人。他最近指导了 6 名研究员和初级教员，其中许多人获得了独立拨款支持。此外，他还将在哈佛医学院 K30 资助的“临床科学学者”项目中教授以患者为中心的初级研究人员。因此，在该奖项的支持下，他将对未来以患者为导向的多个层面的研究产生重大影响。