Dual-Function Reagents in Organic Synthesis

有机合成中的双功能试剂

• 批准号: 2888410
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2888410
• 关键词: Dual; Function; Reagents; Organic; Synthesis

Carboxylation is a fundamental reaction in organic chemistry. We are heading a program for developing novel reagents for carboxylation reactions (for a recent publication see: Angew. Chem. Int. Ed. 2023, DOI: 10.1002/anie.202218371). These reagents are described as dual-function reagents as they can perform multiple roles in the reaction. The advantage of our dual-function reagents is that they avoid specialized equipment and sensitive/hazardous reagents. These reagents also display unique reactivity. The project will begin with a focus on carboxylation chemistry but will provide the successful candidate with an opportunity to express their creativity in other areas of organic synthesis, for example sulfur chemistry and amide bond formation. The successful candidate will also gain experience in isotope labeling with an aim to develop collaborations with experts from academia and industry.The successful candidate will acquire skills in synthetic organic chemistry, organometallic chemistry and catalysis. Within this, the candidate will be exposed to a range of technologies, such as photochemistry and electrochemistry. Analytical techniques, both experimental (NMR, CV, UV-Vis, kinetic analysis) and computational will be used. Candidates will be encouraged to present their research at both national and international conferences.

羧化是有机化学中的基本反应。我们正在领导一项开发用于羧化反应的新型试剂的计划（最近的出版物请参见：Angew.Chem.Int.Ed.2023，DOI：10.1002/anie.202218371）。这些试剂被描述为双功能试剂，因为它们可以在反应中发挥多种作用。我们的双功能试剂的优点是避免使用专用设备和敏感/危险试剂。这些试剂还表现出独特的反应性。该项目将首先关注羧化化学，但将为成功的候选人提供在有机合成其他领域（例如硫化学和酰胺键形成）表达创造力的机会。成功的候选人还将获得同位素标记方面的经验，旨在与学术界和工业界的专家开展合作。成功的候选人将获得合成有机化学、有机金属化学和催化方面的技能。在此期间，候选人将接触一系列技术，例如光化学和电化学。将使用实验（NMR、CV、UV-Vis、动力学分析）和计算分析技术。我们将鼓励候选人在国内和国际会议上展示他们的研究成果。