Reagents for spatiotemporal control over TRPM/TRPC function (P24)

TRPM/TRPC 功能时空控制试剂 (P24)

• 批准号: 407463061
• 金额: --
• 依托单位: Fach Pharmazeutische Chemie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/407463061?language=en
• 关键词: Reagents; spatiotemporal; control; over; TRPM

In project P24 we will generate new chemical reagents with which to modulate and study native TRP channels. We will develop photoswitchable reagents for modulating TRP channels in their physiological contexts with high spatiotemporal precision, both using classical approaches (sterically demanding photoswitches on known pharmacophores) and developing a novel, general approach (biolocalisation photocontrol). We will also synthesise photoaffinity label derivatives of TRP modulators to characterise their binding sites, and provide ongoing synthetic support to the CRC. P24 therefore promotes the general discovery, development, characterisation and use of modulators for native TRP channels.

在P24项目中，我们将生成新的化学试剂来调节和研究天然TRP通道。我们将开发光开关试剂，用于在生理环境下以高时空精度调节TRP通道，既使用经典方法（已知药效团的立体要求光开关），也开发一种新的通用方法（生物定位光控制）。我们还将合成TRP调节剂的光亲和标记衍生物，以表征它们的结合位点，并为CRC提供持续的合成支持。因此，P24促进了本地TRP信道调制器的普遍发现、发展、表征和使用。