Neurological Emergencies Treatment Trials (NETT) Network Clinical Site Hubs (U10)

描述(申请人提供)：本申请的具体目标是：(1)创建一个由急诊内科医生、神经学家和神经外科医生组成的临床研究网络，通过执行NINDS赞助的临床试验，共同努力以高效的方式为急性神经疾病患者开发更多更好的治疗方法。以及(2)进行两个涉及神经紧急情况的大型、简化的第三阶段临床试验，以证明该网络的能力，并激发人们对NETT网络关于未来合作的普遍兴趣。我们汇集了马里兰大学和约翰霍普金斯大学强大的专业知识在临床试验管理和神经紧急情况方面的跨学科小组专家，并与农村、城市和郊区的9家社区医院建立了合作伙伴关系。我们的临床现场(联盟)中心(CSH)领导层包括一名神经科医生和三名急诊内科医生。CSH的代表包括癫痫、成人和儿童创伤医学、中风、神经外科、神经重症监护、神经放射学、生理学和儿科的专家。未来，根据正在进行的临床试验，CSH的代表可能会因参与的专家和代表网络活动的相对努力而有所不同。CSH领导层还将与马里兰紧急医疗服务系统研究所(MIEMSS)密切合作，根据进行临床试验的需要实施院前方案。CSH正在与急救医学合作，主要调查人员说。CSH领导层将支持中心和分支研究团队在患者招募和管理工作以及他们的行政需求方面的工作。我们网络的枢纽和辐条之间的通信将使用各种方法来促进，包括努力充分利用互联网和相关的宽带技术。CSH领导层将勤奋工作，补充NETT网络领导层的活动，创建一家马里兰州紧急研究企业，为NETT网络的目标和成功做出贡献，并使我们的临床试验患者受益。最终，全州日常紧急神经护理的提供将得到加强，从NETT网络研究企业学到的经验教训可能有利于全州紧急护理的提供。

DESCRIPTION (provided by applicant): The specific objectives of this application are to: (1) create a clinical research network of emergency medicine physicians, neurologists, and neurosurgeons that will work together to develop in an efficient manner more and better treatments for patients with acute neurological disorders through execution of NINDS-sponsored clinical trials. And (2) conduct two large, streamlined phase III clinical trials involving neurological emergencies to demonstrate the capability of the Network and to stimulate general interest in the NETT Network regarding future collaborations. We have brought together an interdisciplinary group expert in clinical trials management and neurologic emergencies from the robust expertise available at the University of Maryland and the Johns Hopkins University and have created a partnership with 9 community hospitals in rural, urban, and suburban settings. Our Clinical Site (consortium) Hub (CSH) leadership includes a neurologist and 3 emergency medicine physicians. Representation in the CSH includes experts in epilepsy, adult and pediatric trauma medicine, stroke, neurosurgery, neurointensive care, Neuroradiology, physiatry, and pediatrics. In the future, depending on the clinical trials in progress, representation in the CSH can vary as to the experts involved and relative effort on behalf of network activities. The CSH leadership will also work closely with the Maryland Institute for Emergency Medical Services Systems (MIEMSS) to effect pre-hospital protocols, as needed for the clinical trials to be conducted. The CSH is partnering with emergency medicine spoke principal investigators. The CSH leadership will support the hub and spoke research teams in their patient recruitment and management efforts as well as for their administrative needs. Communication amongst the hubs and spokes of our network will be promoted using a variety of methods, including efforts to fully utilize the internet and related broadband technologies. CSH leadership will work diligently to complement the activities of the NETT Network leadership to create a State of Maryland emergency research enterprise that will contribute to the objectives and success of the NETT Network and benefit our clinical trial patients. Ultimately the delivery of day to day emergent neurological care throughout the State will be enhanced and the lessons learned from the NETT Network research enterprise may benefit the delivery of emergency care statewide.