Development of Wearable Sensors for Medical Diagnostics and Monitoring Health and Wellbeing

在这个项目中，我们将致力于开发新型先进的可穿戴生物传感器，它既可以用于医疗保健应用，也可以用于评估生活方式和健康指标（如水合作用或压力）。我们的目标是扩大我们的传感能力，将微制造电化学生物传感器与微流体相结合，开发新型生物传感器，可以对身体的代谢活动进行无创采样。该项目将实现以下目标/里程碑：我们将开发一个初始的微传感器平台，作为手表或贴片/绷带，并探索一系列潜在的分析物来测量，包括电解质，pH值，皮质醇和激素，如肾上腺素，作为第一个目标里程碑1.2。我们将参与一个病人和公众参与和参与（PPIE）项目，探索与行业、利益相关者、临床医生、医疗保健专业人员和护士共同创造产品和概念。我们还将与终端用户群体进行接触，包括老年人以及运动员/运动生理学家。PPIE活动将贯穿整个项目，融入开发的各个方面。3. 传感器阵列将与微流控平台集成，测试从皮肤中提取样本的新方法的有效性，例如使用反向离子电泳（Milestone 3.4）。该平台将与使用低功耗通信接口的智能手机连接，以实现数据收集和存储，信号处理和人工智能来解释结果。培训成果：在项目结束时，学生将对可穿戴生物传感器有新的理解，特别是在以用户为中心的设计概念的背景下，使新技术能够快速部署。学生将获得生物传感器开发的各个方面的培训，包括构建分子界面和数据分析，但重要的是，学生也将接触并推动PPIE的努力。

In this project, we will work to develop novel advanced wearable biosensors which can be used either for healthcare applications or assessing lifestyle and wellbeing markers (such as those for hydration or stress). Our ambition is to expand our sensing capabilities, combining microfabricated electrochemical biosensors with microfluidics to develop novel biosensors that can sample the metabolic activity of the body, non-invasively. The project will deliver the following objectives/milestones:1. We will develop an initial microsensor platform either as a watch or a patch/bandage, and explore a range of potential analytes to measure, including those of electrolytes, pH, cortisol, and hormones such as adrenaline as a first objective Milestone 1.2. We will engage in a programme of Patient and Public Involvement and Engagement (PPIE) exploring the co-creation of products and concepts with industry, stakeholders, clinicians, healthcare professional and nurses. We will also engage with end-user groupings including the elderly as well as sportspeople/exercise physiologists, Milestone 2. The PPIE activity will run throughout the project, integrated into all facets of the developments. 3. The sensor array will be integrated with microfluidic platform, testing the efficacy of new methods to draw sample from the skin including e.g. the use of reverse iontophoresis Milestone 3.4. The platform will be interfaced with a smartphone using a low power communications interface to enable data collection and storage, signal processing and artificial intelligence to interpret the results, Milestone 4. Training outcomes: At the end of the project, the student will have developed new understanding of wearable biosensors in particular within the context of user-centered design concepts, enabling new technologies to be deployed rapidly. The student will obtain training in all aspects of biosensors developments, including building molecular interfaces and data analysis, but importantly the student will also be exposed and then will drive PPIE efforts.