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RESEARCH ON SCOPE & CAUSES OF STILLBIRTH IN THE US

范围研究

基本信息

批准号：
7284368
负责人：
DONALD R COUSTAN
金额：
$ 35.79万
依托单位：
WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-26 至 2011-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7284368
关键词：
Abdomen Ablation Abnormal Karyotype Abruptio Placentae Academy Accounting Accreditation Acid Fast Bacillae Staining Method Acrylamide Acrylamides Activins Activities of Daily Living Acute Address Adenoviruses Administrator Admission activity Adrenal Glands Aerobic Affect Affinity Age Age Distribution Age-Years Agrin Alcian Blue Alcohol or Other Drugs use Algorithms American American Heart Association Amniotic Fluid Amygdaloid structure Anastomosis - action Anatomy Andro-Diane Anencephaly Aneuploidy Anterior Anti-Inflammatory Agents Anti-inflammatory Antibodies Antiviral Agents Aorta Apgar Score Apoptosis Apoptotic Appendix Architecture Archives Area Arteries Arts Ascaridil Asians Attention Autoimmune Diseases Autologous Autopsy Autosomal Recessive Polycystic Kidney Award Back Bacterial Infections Basal Ganglia Basal Plate Basophilia Bathing Beds Benchmarking Benefits and Risks Bereavement Bile fluid Binding Biochemistry Biological Biological Assay Biology Biometry Birth Birth Weight Bladder Blood Blood Banks Blood Vessels Blood and Blood Products Blood capillaries Blood flow Blood specimen Body Weight Boston Boxing Brain Budgets Businesses CD14 Antigen CD14 gene CD3 Antigens CD8-Positive T-Lymphocytes CD8B1 gene Calendar Caliber Canada Cardiac Care given by nurses Caring Case Management Case Series Case-Control Studies Caspase Catchment Area Categories Cause of Death Cell Count Cell Death Cell Line Cell Proliferation Cell Separation Cell surface Cells Cellular biology Censuses Centrifugation Cerebellum Cerebrum Cervical spinal cord structure Cessation of life Charge Chemicals Chemistry Chest Chickenpox Childhood Chromosome abnormality Chromosomes Chronic Cicatrix Classification Client Clinic Clinical Clinical Data Clinical Laboratory Information Systems Clinical Nursing Clinical Pathology Clinical Protocols Clinical Research Clinical Research Protocols Clinical Trials Clinical Virology Clinical assessments Cloning Closure Coagulation Process Code Collaborations Collection Colon Color Communicable Diseases Communication Communities Community Hospitals Community Outreach Community Practice Comparative Study Compatible Complement Complex Computer Systems Computer software Computers Conceptions Condition Conduct Clinical Trials Congenital Abnormality Congenital Heart Defects Congo Red Consensus Consent Consent Forms Consult Consultations Continuing Education Control Groups Contusions Core Facility Counseling Count County County Hospitals Coupled Creativeness Critical Illness Crown rump length Cryopreservation Current Procedural Terminology Codes Cytokeratin 18 Cytomegalovirus Cytometry DNA DNA Fragmentation DNA Markers DNA Nucleotidylexotransferase DNA Probes DNA Sequence Analysis DNA Sequence Rearrangement DNA analysis Daily Data Data Analyses Data Files Data Quality Data Reporting Data Storage and Retrieval Databases Date Available Date/Time Death Rate Death Records Decidua Defect Deformity Dental crowns Deoxyribonuclease I Deoxyribonucleases Deposition Depth Descending colon Detection Developed Countries Developing Countries Development Diabetes Mellitus Diagnosis Diagnostic Digestion Digit structure Digoxigenin Dimensions Disadvantaged Discipline of Nursing Discipline of obstetrics Disease Disruption Dissection Distal Distal part of ileum Doctor of Medicine Doctor of Philosophy Documentation Dosage Forms Dose Down Syndrome Drops Drug Hypersensitivity Drug Interactions Ductal Dyes Dysplasia Early identification Edema Edetic Acid Education Educational Activities Educational Curriculum Educational process of instructing Educational workshop Edward&apos s syndrome Electron Microscopy Electronic Mail Electronics Emergency Situation Employee Strikes Endocrinology Endometrial Endopeptidase K Enrollment Enterovirus Environment Enzyme Immunoassay Enzyme-Linked Immunosorbent Assay Enzymes Epidemiologic Monitoring Epidemiology Epithelial Cells Epitopes Equilibrium Equipment Escherichia coli Esophageal Estriol Ethnic Origin Etiology Evaluation Event Evidence based treatment Excision Exercise Eye Face Faculty Failure Family Family member Fatty acid glycerol esters Feedback Feeling Fellowship Fellowship Program Fertility Fetal Death Fetal Growth Fetal Growth Retardation Fetal Heart Fetal Monitoring Fetal Resorption Fetal Tissues Fetal Weight Fetofetal Transfusion Fetomaternal Transfusion Fetus Fever Fibrin Fibrinoid necrosis Figs - dietary Financial compensation First Pregnancy Trimester Floor Flow Cytometry Fluorescence Fluorescent Antibody Technique Fluorescent in Situ Hybridization Food Formalin Foundations Freezing Frequencies Fresh Tissue Functional disorder Funding Funding Mechanisms Future Gel Gender Gene Expression Regulation General Population Generations Genetic Genetic Counseling Genetic Materials Genetic Medicine Genetic Transcription Genetic screening method Genetics and Medicine Genets Genome Genus Cola Geographic Locations Gestational Age Gestational Diabetes Glass Glutaral Goals Gonadal structure Government regulations Gram&apos s stain Grant Grief reaction Growth Growth Disorders Guidelines Gynecologic Gynecologic Oncology Gynecology Haemophilus influenzae Hand Harvest Head Head circumference Health Health Personnel Healthcare Heart Heel Height Hematocrit procedure Hematological Disease Hematology Hematoma Hematopoiesis Hematoxylin Hematoxylin and Eosin Staining Method Hemoglobinopathies Hemorrhage Hereditary Disease Herpes Simplex Infections Herpes zoster disease High-Risk Pregnancy Hippocampus (Brain)Hispanics Histologic Histology Histopathology Holoprosencephaly Home environment Hormonal Hormones Hospital Departments Hospital Nursing Hospital Personnel Hospital Records Hospital Referrals Hospitals Hour House Staffs Housing Human Human Chorionic Gonadotropin Human Parvovirus B19 Human Placental Lactogen Human Resources Hydrogen Peroxide Hydrops Fetalis Hypaque Hyperglycemia Hypersensitivity Hypertension Hypertension induced by pregnancy Hypothalamic structure Hypoxia ICD-9 ICD-9-CM Image Image Analysis Immune Immune response Immunoassay Immunobiology Immunoglobulin G Immunohistochemistry Immunologics Immunology Immunomodulators Immunoprecipitation Impairment In Situ In Situ Hybridization In Vitro Inborn Errors of Metabolism Incubators Individual Infant Infarction Infection Infection Control Infection of amniotic sac and membranes Infectious Agent Infectious Diseases Research Infiltration Inflammation Inflammatory Inflammatory Response Information Centers Information Management Information Services Information Systems Information Technology Informed Consent Inguinal region Inhibin A Injury Inpatients Institution Instruction Insulin-Dependent Diabetes Mellitus Insurance Insurance Coverage Interferon Type II Interferons Interleukin-1 Interleukin-10 Interleukin-6 Interleukin-9 Interleukins International Intervention Intervention Trial Intranet Invasive Investigation Investigative Techniques Investments Ischemia Island Islets of Langerhans Joint Commission on Accreditation of Healthcare Organizations Joints Karyotype Kidney Knowledge Label Laboratories Laboratory Research Laboratory Study Labyrinth Language Large Intestine Laryngoscopes Larynx Laser Scanning Confocal Microscopy Lasers Laws Lead Leadership Left Left atrial structure Left kidney Left ventricular structure Leg Legitimacy Length Lesion Letters Life Light Link Liquid substance Live Birth Liver Lobe Locales Logistics Lung Luxol Fast Blue MBS MA 4 Magnesium Malignant Neoplasms Mammography Management Information Systems Manuals Maps Marshal Maryland Massachusetts Massage Measurement Measures Meconium Mediating Medicaid Medical Medical Care Team Medical Records Medical Research Medical Societies Medical Staff Medical Students Medical Surveillance Medical center Medicare Medication Systems Medicine Melanocytic nevus Membrane Meninges Mesentery Metabolic Diseases Metadata Methods Microbiology Microscope Microscopic Midbrain structure Minor Missed Abortion Mitochondrial Carnitine Palmitoyltransferase Pathway Mitral Valve Modality Modeling Modems Modification Mole the mammal Molecular Molecular Biology Molecular Cloning Molecular Cytogenetics Molecular Immunology Monitor Monoclonal Antibodies Mononuclear Morbidity - disease rate Morphology Mosaicism Mothers Mucicarmine Mus Muscle Myopathy N(delta)-acetylornithine, -isomer N-dodecanoylglutamic acid, -isomer, sodium salt NCAM1 gene Names Napping National Institute of Allergy and Infectious Disease National Institute of Child Health and Human Development Native Americans Natural Killer Cells Nature Neonatal Neonatal Intensive Care Neonatology Nerve Neural Tube Defects Neurokinin B Neuromuscular Diseases New England Newborn Infant Newsletter Nitrogen Nomenclature Normal Range Northern Blotting Not Hispanic or Latino Nuchal Translucency Nuchal Translucency Measurement Nuclear Numbers Nurseries Nurses Nursing Education Nursing Faculty Nursing Records Nursing Research Nursing Schools Nursing Staff Observational Study Obstetrical Nursing Obstetrics Departments Occupations Oligohydramnios Online Systems Operating Rooms Operative Surgical Procedures Organ Organ Weight Organism Osteogenesis Imperfecta Other Finding Otoscopes Outcome Outcomes Research Outpatients Output Ownership Oxidative Stress PTPRC gene Pain management Paint Palpation Pamphlets Pancreas Paper Papillomavirus Paraffin Paraffin Embedding Parental Consent Parents Parietal Participant Parvovirus Patau&apos s syndrome Pathogenesis Pathologic Pathologist Pathology Pathology Department, Hospital Pathology Report Pathology, Other Patient Care Patient Discharge Patient Transfer Patient currently pregnant Patients Pediatric Surgical Procedures Pediatrics Peer Review Peptides Percoll Performance Perfusion Perinatal Perinatal mortality demographics Peroxidase Peroxidases Personal Satisfaction Persons Pharmaceutical Preparations Pharmacy facility Phenotype Photography Physical assessment Physical shape Physicians Physiology Phytohemagglutinins Pituitary Gland Placenta Placentation Policies Polymerase Chain Reaction Pontine structure Population Population Heterogeneity Positioning Attribute Postdoctoral Fellow Postmortem Changes Postpartum Period Pre-Eclampsia Preclinical Drug Evaluation Pregnancy Pregnancy Complications Pregnancy Outcome Pregnancy in Diabetics Pregnancy loss Pregnancy-Associated Plasma Protein-A Pregnant Women Premature Birth Premature Labor Prematurity of fetus Prenatal Diagnosis Prenatal care Preparation Price Principal Investigator Printing Private Practice Procedures Process Production Productivity Professional Education Professional counselor Progesterone Prostate Proteins Protocols documentation Provider Psoas Muscles Ptosis Publications Published Comment Publishing Pulse Oximetry Purpose Pylorus Quality Control Quality Indicator RNA RNA Interference RNA analysis Race Radiology Specialty Rate Reader Reading Recording of previous events Records Recovery Reference Values Registered nurse Regulation Relative (related person)Renin Reporting Reproductive Endocrinology Reproductive Health Reproductive Immunology Reproductive Medicine Research Research Activity Research Design Research Personnel Research Subjects Research Support Residencies Resolution Resources Respiratory Diaphragm Respiratory Therapy Resuscitation Retained Placenta Retrieval Reverse Transcriptase Polymerase Chain Reaction Review Committee Rhode Island Ribonucleases Right atrial structure Right kidney Right ventricular structure Rights Risk Role Route Running Rupture Safety Salivary Glands Sampling Scalp structure Scanning Scanning Transmission Electron Microscopy Procedures Schedule School Nursing Schools Scintillation Counter Screening procedure Second Pregnancy Trimester Seizures Self-Evaluation Programs Sepharose Sepsis Series Serum Serum Markers Services Shock Shoulder Signal Transduction Signs and Symptoms Silver Methenamine Simplexvirus Site Skeletal Muscle Skeletal system Skin Slide Smith-Lemli-Opitz Syndrome Social Environment Social Work Social Work Department, Hospital Social Workers Societies Solutions Sorting - Cell Movement Specialist Specific qualifier value Specimen Speed Spinal Cord Spleen Spontaneous abortion Stable Populations Staff Development Staging Staining method Stains Standardization Standards of Weights and Measures Staphylococcus aureus Sterility Streptococcus Streptococcus Group B Structure Structure of choroid plexus Students Support System Surgeon Surgical incisions Suspension substance Suspensions Syndrome System Systematized Nomenclature of Medicine T-Lymphocyte Teaching Hospitals Techniques Technology Telefacsimile Telephone Telephone Number Temperature Termination of pregnancy Terminology Test Result Testing Testis Text Textbooks Thanatophoric Dysplasia Therapeutic Thick Thinking Thrombosis Thrombus Thymidine Thymus Gland Thyroid Gland Time Tissue Sample Tissues Title Today Toes Tolonium chloride Tongue Toxoplasma Trachea Training Transfection Transferase Transfusion Transmission Electron Microscopy Trauma Trichrome stain method Tricuspid valve structure Triplet Multiple Birth Triploidy Trypsin Tumor Markers Tumor Necrosis Factor Ligand Superfamily Member 6 Tumor Necrosis Factor-alpha Turner&apos s Syndrome Twin Multiple Birth U-Series Cooperative Agreements Ultrasonography Umbilical cord structure Uncertainty Unexplained stillbirth Uninsured Uniparental Disomy United States United States Dept. of Health and Human Services United States National Institutes of Health Universities Update Upper arm Upper digestive tract structure Urethra Urinalysis Urinary tract Urine Uterus Vaginal delivery procedure Variant Vasculitis Venous blood sampling Vertebral column Veterinary Medicine Villous Villus Viral Viral Gastroenteritis Virus Virus Diseases Visit Water Week Weight Western Blotting Wisconsin Wolves Woman Women&apos s Health Women&apos s Role Wood material Work Writing Xeroradiography abortion abstracting age related aging brain alpha-difluoromethyl-DOPA, -isomer alpha-methylornithine dihydrochloride, -isomer amnion base brain morphology capillary capitate bone case control cell growth chemotherapy clinical application clinical epidemiology clinically relevant cohesion cohort college comparative genomic hybridization concept continuing medical education cost cytokine cytotoxic cytotoxicity cytotrophoblast data management day demographics deoxyuridine triphosphate design desire digital digoxigenin-11-deoxyuridine triphosphate disease characteristic editorial enzyme linked immunospot assay expectation experience fetal fetal blood fetal infection fetus at risk fetus cell fetus surgery fluorescence microscope follow-up foot gang gene environment interaction graduate medical education hazard hospital laboratories human TNF protein improved in vitro Assay indexing infant outcome inhibin inpatient service instrument instrumentation interest interleukin-10 receptor jejunum laser capture microdissection lectures lens lung maturation macrophage malformation maternal serum maternal serum markers medical schools medical specialties member microwave electromagnetic radiation molecular pathology mortality multidisciplinary neonatal morbidity neonatal resuscitation neonate nephrogenesis neuropathology neutrophil normotensive novel oncology optical disc outreach outreach program parity pediatric department pediatrician peripheral blood pituitary fossa pregnancy disorder prenatal prevent professor programs promoter prophylactic prospective protective effect protocol development psychologic purge quality assurance radius bone structure receptor reproductive research and development research clinical testing research facility research study respiratory response rib bone structure routine Bacterial stain sample collection sample fixation satisfaction skeletal dysplasia skills social spatial relationship spine bone structure statistical service statistics steroid hormone stillbirth subcutaneous success symposium tissue culture tissue processing tissue/cell culture tool trafficking trend trial comparing tripolyphosphate trophoblast urinary virology water quality

项目摘要

DESCRIPTION (provided by applicant): Women and Infants Hospital (WIH) has served as the regional resource for tertiary obstetrical and neonatal care for decades for all the communities in Rhode Island and those of Bristol County, MA. This compact, contiguous area, well defined by state and county boundaries, contains a stable, but racially and ethnically heterogeneous population, producing 20,000 total births and more than 100 stillbirths, annually. Births at WlH represent over 70% of those that occur state-wide and nearly half of those in the region, and are highly representative of those from the region's population. As a specialty hospital, WIH has maintained an active outreach program to the region's nurses, physicians and hospitals for the past 26 years. This active engagement has included educational support in the areas of neonatology, obstetrics and pathology. WlH has also maintained an active collaboration with the Rhode Island Department of Health (DOH) in many initiatives regarding reproductive health. This proposal is made with the enthusiastic support of the Departments of Health of both states and the chiefs of obstetrics and pathology and administration of all the region's 14 hospitals with obstetrical services. The Department of Pathology at WIH has maintained an extensive relational database of its autopsy and placental examinations and relevant clinical information since 1975. Paraffin-imbedded standard tissues sections from these examinations also provide for examination of time-trends of stillbirths occurring in a stable population over the past two decades. The Department has sustained an 80% autopsy rate at WIH and stimulated the rising rate among the other region's hospitals, now at 30%. A rising proportion of the stillbirths occurring at other hospitals are being referred to WlH for autopsy and placental examination. Consequently, because of the leadership role of WIH in RI and Bristol County, MA, the close proximity of the 14 hospitals serving its population, and the collegial relations among health care providers, this region is well adapted to provide the resources for a population-based study of the causes of stillbirth in a stable, diverse population-based sample of 20,000 annual births.

描述（由申请人提供）：几十年来，妇婴医院 (WIH) 一直是罗德岛州和马萨诸塞州布里斯托尔县所有社区三级产科和新生儿护理的区域资源。这个紧凑、连续的地区由州和县边界明确界定，拥有稳定但种族和族裔异质的人口，每年产生 20,000 名新生儿和 100 多名死产。 WlH 的出生人数占全州出生人数的 70% 以上，占该地区出生人数的近一半，并且高度代表该地区的人口。作为一家专科医院，WIH 在过去 26 年里一直对该地区的护士、医生和医院开展积极的外展计划。这种积极参与包括新生儿学、产科和病理学领域的教育支持。 WlH 还与罗德岛州卫生部 (DOH) 在许多有关生殖健康的举措中保持着积极的合作。这项提议得到了两国卫生部以及该地区所有 14 家提供产科服务的医院的产科、病理科和行政部门负责人的热情支持。自 1975 年以来，WIH 病理学系一直维护着尸检和胎盘检查以及相关临床信息的广泛关系数据库。这些检查中的石蜡包埋标准组织切片还可以用于检查过去二十年稳定人群中发生的死产的时间趋势。该部门在 WIH 维持了 80% 的尸检率，并带动其他地区医院的尸检率不断上升，目前已达到 30%。在其他医院发生的死产中，越来越多的死产被转送到 WlH 进行尸检和胎盘检查。因此，由于 WIH 在罗德岛州和马萨诸塞州布里斯托尔县的领导作用、为其人口提供服务的 14 家医院距离很近，以及医疗保健提供者之间的合作关系，该地区非常适合为以每年 20,000 名出生人口为基础的稳定、多样化的人口样本中死产原因的人口研究提供资源。