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NICHD Cooperative Multicenter Neonatal Research Network

NICHD Cooperative Multicenter Neonatal Research Network
NICHD 多中心新生儿合作研究网络
批准号:
7219993
负责人:
KATHLEEN A KENNEDY
金额:
$49.33万
依托单位国家:
美国
项目类别:
财政年份:
1998
资助国家:
美国
项目状态:
已结题
起止时间:
1998-07-17 至 2011-03-31
关键词:
AbdomenAbscessAccident and Emergency departmentAccountingAchievementAcidsAcuteAddressAdministratorAdmission activityAdolescenceAdrenal Cortex HormonesAdverse effectsAdvisory CommitteesAdvocateAfrican AmericanAgeAll SitesAmericanAmerican College of Obstetricians and GynecologistsAmerican Heart AssociationAmino AcidsAminophyllineAmmoniaAmniocentesisAmphotericinAncillary StudyAnesthesiologyAnimal ExperimentationAnimalsAnnual ReportsAppendixAppointmentAreaArtsAsiansAsphyxiaAspirinAttentionAttenuatedAttitudeAudiologyAuditory systemAwardB lymphocyte immortalizationBackBasic ScienceBedsBenchmarkingBilirubinBiochemistryBioethicsBiologyBiometryBirthBirth WeightBlindedBlindnessBlood PressureBoard CertificationBrainBrain InjuriesBreast FeedingBronchopulmonary DysplasiaCanadaCandidaCannulasCardiacCardiologyCaregiversCaringCarmustine/Cytarabine/Etoposide/MelphalanCase ManagementCatchment AreaCellsCensusesCerebral PalsyCertificationCesarean sectionCessation of lifeChairpersonCharacteristicsChargeChildChild DevelopmentChildhoodCitiesClassClassificationClinicClinic VisitsClinicalClinical Ethics CommitteesClinical InvestigatorClinical ResearchClinical ServicesClinical SkillsClinical TrialsClinical Trials Cooperative GroupClinics and HospitalsCohort StudiesCold TherapyCollaborationsCollectionCommitCommittee MembersCommunicable DiseasesComplementComplexComprehensive Health CareComputer softwareComputerized Medical RecordComputersConditionConfidence IntervalsConflict (Psychology)ConsensusConsentConsent FormsConsultConsultationsContinuity of Patient CareContinuous Positive Airway PressureContractsCore FacilityCounselingCountryCountyCounty HospitalsCritical CareCritical IllnessDNADNA SequenceDailyDataData AnalysesData CollectionDatabasesDedicationsDefectDeglutitionDelivery RoomsDevelopmentDevelopmental EndocrinologyDevicesDexamethasoneDiabetes MellitusDiagnosisDiaphragmatic HerniaDietary InterventionDirect CostsDisadvantagedDisciplineDiscipline of obstetricsDiseaseDistantDistrict HospitalsDoctor of MedicineDoctor of PhilosophyDoseDouble-Blind MethodDrainage procedureDyesEconomicsEducationEducational CurriculumEducational process of instructingEducational workshopEffectivenessElevatorEmergency SituationEmergency treatmentEncephalopathiesEndocrinologyEndocrinology, OtherEnrollmentEnteral FeedingEnvironmentEnvironmental air flowEpidemiologic StudiesEpidemiologistEpidemiologyEquationEquilibriumEquipmentEquipment and SuppliesEquipoiseEthnic OriginEvaluationEventEvidence Based MedicineEvoked Potentials, Auditory, Brain StemExcisionExclusion CriteriaExpenditureExperimental DesignsExtremely Low Birth Weight InfantFacility Construction Funding CategoryFacultyFamilyFellowshipFellowship ProgramFemaleFetal GrowthFetusFinancial SupportFloorFollow-Up StudiesFoundationsFriendsFundingFunding AgencyFundoplicationFutureGastroenterologyGastrostomyGenderGene Expression RegulationGeneral AnesthesiaGeneral HospitalsGeneric DrugsGenesGeneticGenetic screening methodGenomicsGenotypeGestational AgeGiftsGlutamineGoalsGoldGrantGreater sac of peritoneumGrowthGrowth FactorGuidelinesGynecologyHIVHealth Maintenance OrganizationsHealth PolicyHealth Services ResearchHealth educationHealthcareHearingHelicopterHematologyHigh-Frequency VentilationHispanicsHome visitationHospital CostsHospital DepartmentsHospital Medical StaffHospital VolunteersHospitalsHourHouse CallHousingHuman MilkHuman ResourcesHumanismHypertensionHyponatremiaHypotensionHypoxiaIleocecal ValveImageImpairmentIncomeIndividualIndomethacinIndustryInfantInfant CareInfant DevelopmentInfant HealthInfectionInfertilityInflammatory ResponseInfluentialsInformation SciencesInformation SystemsInformed ConsentInositolInpatientsInstitutesInstitutionInsulinInsuranceInsurance CoverageIntensive CareInternal MedicineInternationalInterventionIntestinal PerforationIntestinesIntravenousIntubationInvestigational DrugsJointsJournalsJudgmentK-Series Research Career ProgramsLaboratoriesLaboratory ResearchLaparotomyLeadLeftLengthLength of StayLettersLibrariesLifeLife StyleLigationLightLinkLiposomesLiquid substanceLiverLiver DysfunctionLocal anesthesiaLocationLogistic RegressionsLong-Term EffectsLow Birth Weight InfantLungMagnetic Resonance ImagingManuscriptsMasksMaster of Public HealthMaster&aposs DegreeMaternal and Child HealthMeasuresMechanical ventilationMeconium AspirationMedicaidMedicalMedical ErrorsMedical EthicsMedical IndigencyMedical InformaticsMedical RecordsMedical StaffMedical centerMedicineMeningitisMeningomyeloceleMentored Clinical Oncology AwardMentored Clinical Scientist AwardMentored Patient-Oriented Research Career Development AwardMentorsMentorshipMesoporphyrinsMeta-AnalysisMethodsMexican AmericansMicrobiologyMinnesotaModificationMolecularMolecular BiologyMolecular MedicineMonitorMorbidity - disease rateMossesMothersMulticenter StudiesMulticenter TrialsMultiple PregnancyMycosesNamesNational Institute of Child Health and Human DevelopmentNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of Drug AbuseNecrotizing EnterocolitisNeonatalNeonatal Brain InjuryNeonatal Intensive CareNeonatal Intensive Care UnitsNeonatologyNephrologyNetherlandsNeurodevelopmental ImpairmentNeurologicNeurological outcomeNeurological statusNeurologyNew EnglandNew JerseyNew ZealandNewborn InfantNewborn Respiratory Distress SyndromeNitric OxideNobel PrizeNoseNumbersNurseriesNursesNursing ResearchNursing ServicesObservational StudyObstetrics DepartmentsOccupational TherapistOdds RatioOmega-3 Fatty AcidsOperating RoomsOperative Surgical ProceduresOphthalmologistOphthalmologyOralOrthopedicsOther FindingOtolaryngologyOutcomeOutcome MeasureOutcomes ResearchOutpatientsOxidative StressOxygenPDC genePainPalivizumabPaperParenteral NutritionParentsParticipantPatent Ductus ArteriosusPathogenesisPathologistPathologyPatient CarePatientsPediatric RadiologistPediatric ResearchPediatric Surgical ProceduresPediatricsPeer ReviewPelvisPerformancePerinatalPerinatal CarePerinatal EpidemiologyPerinatal InfectionPerinatologyPeripheralPeritonealPersistent Fetal Circulation SyndromePersonsPharmaceutical PreparationsPhototherapyPhysician ExecutivesPhysiciansPhysiologyPilot ProjectsPlacebosPlasmaPlatelet Count measurementPlayPliabilityPoliciesPopulationPositioning AttributePostdoctoral FellowPostoperative PeriodPregnancyPregnant WomenPremature InfantPremature LaborPrematurity of fetusPreparationPreventionPrincipal InvestigatorPrivate HospitalsProbioticsProceduresProcessProductivityProgram DevelopmentProphylactic treatmentProteinsProtocol ComplianceProtocols documentationPsyche structurePsychologistPublic HealthPublic Health InformaticsPublic Health NursesPublic Health NursingPublic Health SchoolsPublicationsPublished CommentPublishingPulmonologyPurposeQuality ControlRaceRadioimmunoassayRadiology SpecialtyRandomizedRandomized Clinical TrialsRandomized Controlled Clinical TrialsRandomized Controlled TrialsRangeRateRecommendationRecordsRegistered nurseRegistriesRelative (related person)Relative RisksReportingReproductive HealthResearchResearch DesignResearch Ethics CommitteesResearch PersonnelResearch Project GrantsResearch TrainingResidenciesResourcesRespiratory FailureRespiratory TherapyRestRetinal DiseasesRetinopathy of PrematurityReview CommitteeReview, Systematic (PT)RiskRisk FactorsRoleRosaRotationRunningSafetySample SizeSamplingScheduleSchemeSchoolsScienceScoreScreening procedureSecureSecuritySedation procedureSeizuresSenior ScientistSepsisSeriesSerumServicesSeverity of illnessSex CharacteristicsShunt DeviceSideSiteSkinSocial Security NumberSocial WorkSocial WorkersSocietiesSocioeconomic StatusSodiumSourceSpecialistSpecific qualifier valueSpeechStandardizationStandards of Weights and MeasuresStatistically SignificantSterile coveringsSterilitySteroidsStomachStomasStudy SectionSubgroupSubstance abuse problemSupervisionSupplementationSupport GroupsSupraventricular tachycardiaSurgeonSurgical suturesSurveysSurvival RateSurvivorsSyndromeSystemTailTaurineTechniquesTechnology AssessmentTelephoneTelephone NumberTennesseeTeratogensTestingTexasTextbooksTherapeuticThinkingTimeTinTracheostomy procedureTrainingTraining ProgramsTransfusionTranslationsTransportationTreatment ProtocolsTubeUSA GeorgiaUltrasonographyUninsuredUnited States Agency for Healthcare Research and QualityUnited States Food and Drug AdministrationUnited States National Institutes of HealthUniversitiesUpper armUrologyVaginal delivery procedureValidationVariantVasoconstrictor AgentsVenousVentilatorVery Low Birth Weight InfantVisionVisitVital StatisticsVitamin AWagesWashingtonWaterWeekWestern Asia GeorgiaWisconsinWomanWood materialWorkWritingbasecareerclinical epidemiologycohortcollegeconceptcostcost effectivenesscytokinedata managementdatabase designdaydeafnessdemographicsdesigndisabilitydisease mechanisms studyearly childhoodearly onsetelementary schoolemotional distressexperiencefeedingfetalfetus surgeryfollow-upfootgastrointestinalhealth care economicshigh schoolhuman subjectimprovedinclusion criteriaindexinginfancyinfant outcomeinhaled nitric oxideinner cityinnovationinsightinstructorinterestintervention programlecturesmalemedical schoolsmedical specialtiesmembermortalitynatural hypothermianeonatal hypoxic-ischemic brain injuryneonatal resuscitationneonateneuroimagingneurosurgerynewsoncologyosteopathoutcome forecastpathogenpatient safetypediatric departmentpediatricianphosducinphosphoric diester hydrolasepilot trialpostnatalpreferenceprenatalpreventprofessorprogramsprospectiveracial and ethnic disparitiesresearch facilityrespiratoryrole modelschool healthsexsimulationsizeskillssoundstatisticssuccesssuckingsurfactantsymposiumthiazidetreatment effecttrendtrial comparingtyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanineuser-friendlywound

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DESCRIPTION (provided by applicant): OVERVIEW. UT Houston is a member of both the MFM and Neonatal Research Networks. It provides the following to the Neonatal Network: 1. A large, high-risk, and growing population. In 2003, we had a total of 9212 deliveries, 1181 NICU admissions, & 369 VLBW infants in our 2 hospitals which house 136 total NICU beds: Memorial Hermann Hospital (MHH), a private hospital with a large referral base, and Lyndon Baines Johnson General Hospital, (LBJ), a county hospital serving a largely Mexican American population; 2. High total enrollment in Network studies. We ranked 3rd of 16 Network centers in the Hypothermia & Benchmarking Trials, 2nd in the Phototherapy & Glutamine Trials, and 1st in the Premie Inhaled Nitric Oxide Trial; 3. A PI & CoPI skilled in clinical research & committed to the Network. The PI is Jon Tyson, MD, MPH, Director of the Center for Clinical Research and Evidence Based Medicine & recipient of the Douglas K. Richardson Award for perinatal and pediatric healthcare research and the Distinguished Educator Award from the Association of Clinical Research Training Program Directors. The CoPI is Kathleen Kennedy, MD, MPH, Director of the Perinatal Epidemiology Program and the Master's Degree Program in Clinical Research. They have served as PI and CoPI for the past 14 years (10 in Dallas & 4 in Houston) and are known for their dedication to exemplary research & helping other investigators. Dr. Tyson chaired the Vitamin A Committee (follow-up findings recently published), directs the Concurrent Research Committee, and is the only PI to have served continuously on the Protocol Review Committee since its inception. He has also been highly involved in the Hypothermia Trial (in press, New England Journal); 4. Multiple talented faculty taking major roles in Network research. These include a) Brenda Morris, MD who is directing the Phototherapy Trial (enrollment now completed; n = 1973 ELBW infants) and is site director for the SUPPORT Trial; b) Martin Blakely, MD, MS, a pediatric surgeon & K23 recipient who directed the recently completed the NEC Observational Study (1st manuscript published; 2nd in review). With Dr. Tyson, he is proposing a major trial based on the results; c) Robert Lasky, PhD, an NIH-funded neuropsychologist who is directing an important substudy of auditory brainstem evoked responses in the Phototherapy Trial (>50% of enrollment from UT Houston); d) Nehal Parikh, DO, a K23 award recipient, who is the site director for the ongoing aEEG study, the MRI secondary study of the Support Trial, and the proposed seizure prophylaxis trial; e) Sue Ramin, MD, PI of the MFM Network and advocate for Neonatal Network studies; and f) Larry Gilstrap, MD, Chairman of Obstetrics, Co PI of the MFM Network, and Neonatal Network Advisory Board member; 5. Methodological & multi-disciplinary expertise. The Center that Dr. Tyson directs provides ready access to 21 faculty with expertise in bioethics, biostatistics, epidemiology, health care economics, and health services research.
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Multicenter Network of Neonatal Intensive Care Units
NICHD Cooperative Multicenter Neonatal Research Network
NICHD Cooperative Multicenter Neonatal Research Network
Multicenter Network of Neonatal Intensive Care Units
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