NICHD Cooperative Multicenter Neonatal Research Network

描述（由申请人提供）：概述。UT休斯顿是MFM和新生儿研究网络的成员。它向新生儿网络提供以下服务：1.一个庞大的，高风险的，不断增长的人口。2003年，我们共有9212名分娩，1181名新生儿重症监护室入院，369名极低出生体重婴儿在我们的2家医院，其中共有136张新生儿重症监护室床位：纪念赫尔曼医院（MHH），一家拥有大量转诊基础的私立医院，和林登贝恩斯约翰逊综合医院（LBJ），一家主要为墨西哥裔美国人服务的县级医院; 2.网络研究中的高总入学率。我们在低温和基准试验中排名16个网络中心的第3位，在光疗和谷氨酰胺试验中排名第2位，在Premie吸入一氧化氮试验中排名第1位; 3。擅长临床研究并致力于网络的PI和CoPI。主要研究者是乔恩泰森，医学博士，公共卫生硕士，临床研究和循证医学中心主任和道格拉斯K。理查森奖的围产期和儿科保健研究和杰出教育家奖从临床研究培训计划主任协会。CoPI是Kathleen Kennedy，MD，MPH，围产期流行病学项目和临床研究硕士学位项目的主任。在过去的14年里，他们一直担任PI和CoPI（10年在达拉斯，4年在休斯顿），并以致力于模范研究和帮助其他研究人员而闻名。Tyson博士担任维生素A委员会主席（最近发表的后续研究结果），指导并行研究委员会，并且是自方案审查委员会成立以来唯一连续任职的PI。他还高度参与了低温试验（在新闻界，新英格兰杂志）; 4。多名才华横溢的教师在网络研究中发挥重要作用。其中包括a）Brenda Morris，医学博士，负责指导光疗试验（现已完成入组; n = 1973名ELBW婴儿），并担任SUPPORT试验的现场负责人; B）Martin Blakely，医学博士，MS，儿科外科医生和K23接受者，负责指导最近完成的NEC观察性研究（第1篇手稿发表;第2篇评论）。与泰森博士，他提出了一个主要的试验的基础上的结果; c）罗伯特拉斯基博士，美国国立卫生研究院资助的神经心理学家谁是指导一个重要的子研究听觉脑干诱发反应的光疗试验（超过50%的学生来自UT Houston）; d）Nehal Parikh，DO，K23奖获得者，他是正在进行的aEEG研究的现场主任，支持试验的MRI二级研究，和拟议的癫痫预防试验; e）Sue拉明，医学博士，MFM网络的PI和新生儿网络研究的倡导者;和f）Larry Gilstrap，医学博士，产科主席，MFM网络的共同PI，新生儿网络咨询委员会成员; 5.方法论和多学科专业知识。泰森博士指导的中心提供了21个具有生物伦理学，生物统计学，流行病学，卫生保健经济学和卫生服务研究专业知识的教师。

DESCRIPTION (provided by applicant): OVERVIEW. UT Houston is a member of both the MFM and Neonatal Research Networks. It provides the following to the Neonatal Network: 1. A large, high-risk, and growing population. In 2003, we had a total of 9212 deliveries, 1181 NICU admissions, & 369 VLBW infants in our 2 hospitals which house 136 total NICU beds: Memorial Hermann Hospital (MHH), a private hospital with a large referral base, and Lyndon Baines Johnson General Hospital, (LBJ), a county hospital serving a largely Mexican American population; 2. High total enrollment in Network studies. We ranked 3rd of 16 Network centers in the Hypothermia & Benchmarking Trials, 2nd in the Phototherapy & Glutamine Trials, and 1st in the Premie Inhaled Nitric Oxide Trial; 3. A PI & CoPI skilled in clinical research & committed to the Network. The PI is Jon Tyson, MD, MPH, Director of the Center for Clinical Research and Evidence Based Medicine & recipient of the Douglas K. Richardson Award for perinatal and pediatric healthcare research and the Distinguished Educator Award from the Association of Clinical Research Training Program Directors. The CoPI is Kathleen Kennedy, MD, MPH, Director of the Perinatal Epidemiology Program and the Master's Degree Program in Clinical Research. They have served as PI and CoPI for the past 14 years (10 in Dallas & 4 in Houston) and are known for their dedication to exemplary research & helping other investigators. Dr. Tyson chaired the Vitamin A Committee (follow-up findings recently published), directs the Concurrent Research Committee, and is the only PI to have served continuously on the Protocol Review Committee since its inception. He has also been highly involved in the Hypothermia Trial (in press, New England Journal); 4. Multiple talented faculty taking major roles in Network research. These include a) Brenda Morris, MD who is directing the Phototherapy Trial (enrollment now completed; n = 1973 ELBW infants) and is site director for the SUPPORT Trial; b) Martin Blakely, MD, MS, a pediatric surgeon & K23 recipient who directed the recently completed the NEC Observational Study (1st manuscript published; 2nd in review). With Dr. Tyson, he is proposing a major trial based on the results; c) Robert Lasky, PhD, an NIH-funded neuropsychologist who is directing an important substudy of auditory brainstem evoked responses in the Phototherapy Trial (>50% of enrollment from UT Houston); d) Nehal Parikh, DO, a K23 award recipient, who is the site director for the ongoing aEEG study, the MRI secondary study of the Support Trial, and the proposed seizure prophylaxis trial; e) Sue Ramin, MD, PI of the MFM Network and advocate for Neonatal Network studies; and f) Larry Gilstrap, MD, Chairman of Obstetrics, Co PI of the MFM Network, and Neonatal Network Advisory Board member; 5. Methodological & multi-disciplinary expertise. The Center that Dr. Tyson directs provides ready access to 21 faculty with expertise in bioethics, biostatistics, epidemiology, health care economics, and health services research.