Reduction of Tobacco Exposure in Pregnancy and Infancy

减少怀孕期和婴儿期的烟草接触

• 批准号: 7489586
• 负责人: AYMAN A EL-MOHANDES
• 金额: $ 11.25万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7489586
• 关键词: Academic Medical Centers; Address; Adenoidectomy; Adverse effects; African American; Age; Area; Asthma; Behavior; Behavior Therapy; Birth; Child; Clinic; Clinical Practice Guideline; Clinical Psychology; Collaborations; Dermal; Development; Developmental Delay Disorders; District of Columbia; Drops; Elderly; Environment; Environmental Tobacco Smoke; Exposure to; Fetus; Frequencies; Goals; Health; Health Sciences; Health Services; Health behavior; Hospitalization; Infant; Infant Mortality; Institution; Intervention; Leadership; Live Birth; Low Birth Weight Infant; Maternal and Child Health; Medicine; Methods; Minor; Minority; Morbidity - disease rate; Mothers; National Institute of Child Health and Human Development; Neonatal; Neonatal Mortality; Nicotine; Numbers; Paper; Participant; Patient currently pregnant; Pediatrics; Perinatal; Pharmacology; Phase; Population; Postpartum Period; Pregnancy; Prevention; Protocols documentation; Public Health; Public Health Schools; Randomized Clinical Trials; Rate; Reporting; Research; Research Personnel; Risk; Risk Factors; Secondary to; Site; Smoke; Smoker; Smoking; Source; Sudden infant death syndrome; Testing; Tobacco; Tobacco smoke; Tonsillectomy; U-Series Cooperative Agreements; Washington; Woman; base; clinical research site; concept; demographics; ear infection; fetal; health care service utilization; infancy; innovation; interest; maternal cigarette smoking; medical schools; mortality; nicotine patch; nicotine replacement; prenatal; prenatal smoking; prevent; respiratory; response; smoking cessation; statistics; tobacco exposure

This continuation application is submitted by the GWUMC investigators in response to LOI #HD-03-106, released June 10, 2003, by the NICHD. The GWUMC investigators intend to collaborate with investigators from other sites in this cooperative agreement towards the goal of the NICHD to examine ways to maximize health and healthy behaviors in a minority population of mothers and children. Smoking during pregnancy continues to be a significant public health problem and is the foremost preventable cause of perinatal morbidity and mortality. Strong evidence exists for adverse effects on the mother, the fetus and the infant. The focus of this application is to address the risk of nicotine exposure to the fetus and during infancy, this risk factor is considered a continuum impacting both health and development in later life. The GWUMC investigators are submitting two concept papers that aim to test the efficacy of innovative intervention methods tailored to reduce fetal and infant exposure to nicotine secondary to maternal smoking and environmental tobacco exposure. The specific aims of the first concept entitled, "The Efficacy of Nicotine Replacement Therapy to Reduce the Risk of Nicotine Exposure in Pregnant Minority Smokers" include: #1- Conduct a qualitative study among pregnant participants to identify barriers and facilitators of using transdermal nicotine patches as a method to quit smoking while pregnant. #2- Conduct a randomized clinical trial to determine the efficacy of a behavioral intervention plus transdermal nicotine compared with a behavioral intervention only among pregnant minority women who are heavy smokers. The specific aims of the second proposed concept entitled, "Prevention of Environmental Tobacco Smoke (ETS) Exposure in Children Age 0-12 Months" include: #1- Assess the frequency and types of health effects, major and minor, associated with prenatal and postpartum exposure to tobacco smoke products (TSP) and environmental tobacco smoke (ETS) among infants. #2- Develop and test the efficacy of a brief, clinic-based intervention to prevent ETS exposure during infancy that is consistent with clinical practice guidelines. The George Washington University Medical Center with its Schools of Medicine and Health Sciences and School of Public Health and Health Services and its active clinical and research sites is a suitable environment to investigate this significant public health problem in collaboration with other academic sites in the district. The investigators collaborating on this application cover a wide s spectrum of expertise in pediatrics, neonatal medicine, high-risk maternal and fetal medicine, pharmacology, health behavior and clinical psychology. Through this application they will demonstrate a strong academic track record in the area of interest and a track record of effective collaboration during phases I and II of the NIH-DC Initiative to Reduce Infant Mortality.

该延续申请由GWUMC调查人员提交，以回应6月发布的LOI＃HD-03-106 10，2003，由NICHD。 GWUMC调查人员打算与其他网站的调查员合作 NICHD目标的合作达成共识，以研究最大化健康和健康行为的方法 母亲和儿童的少数人口。怀孕期间吸烟仍然是重要的公共卫生 问题，这是围产期发病率和死亡率的可预防原因。有强有力的证据表明不利 对母亲，胎儿和婴儿的影响。该应用的重点是解决尼古丁暴露的风险 胎儿和婴儿期间，这种危险因素被认为是影响健康和发展的连续性。 生活。 GWUMC调查人员提交了两篇旨在测试创新干预功效的概念论文 量身定制的方法是为了减少胎儿和婴儿暴露于孕产妇吸烟和环境的尼古丁 烟草暴露。第一个概念的具体目的为“尼古丁替代疗法的功效 降低怀孕少数族裔吸烟者尼古丁暴露的风险”包括：＃1-进行定性研究 怀孕的参与者确定使用透皮尼古丁斑块作为退出的方法的障碍和促进者 怀孕时吸烟。 ＃2-进行随机临床试验以确定行为干预的功效 加上透皮尼古丁与仅在沉重的怀孕少数妇女中的行为干预相比 吸烟者。第二个拟议概念的具体目的标题为“预防环境烟雾烟雾 （ETS）儿童的暴露0-12个月”包括：＃1-评估健康影响的频率和类型，主要和 未成年人，与产前和产后暴露于烟草烟产品（TSP）和环境烟草有关 婴儿中的烟雾（ET）。 ＃2-开发和测试基于诊所的简短干预措施的功效，以防止ETS 婴儿期的暴露与临床实践指南一致。乔治华盛顿大学医学 中心及其医学和健康科学学院以及公共卫生与健康服务学院及其 主动临床和研究站点是调查这个重大公共卫生问题的合适环境 与该地区的其他学术网站合作。在此申请上合作的调查人员涵盖了很大的范围 儿科，新生儿医学，高风险母亲和胎儿医学，药理学，健康方面的专业知识范围 行为和临床心理学。通过此应用程序，他们将在 在NIH-DC倡议的第I和II阶段，感兴趣的领域和有效协作的记录，以减少 婴儿死亡率。