Colorado AIDS Clinical Trials Unit

描述（由申请人提供）：本申请是为科罗拉多州艾滋病临床试验单位（ACTU）继续提供资金的申请，以进行人类免疫缺陷病毒1型（HIV-1）感染及其并发症的发病机制和治疗的临床研究。科罗拉多ACTU将为拟议的艾滋病临床试验小组（ACTG）、国际孕产妇、儿科、青少年艾滋病临床试验（IMPAACT）和艾滋病毒预防试验（HPTN）网络提供科学专业知识和领导。科罗拉多ACTU将隶属于ACTG网络，并将在位于科罗拉多大学医院（UCH CRS）的一个非常成功和具有成本效益的临床研究地点执行ACTG的科学议程。在UCH CRS进行的研究将涉及以下高优先级研究领域：临床管理和合并症的优化；转化研究和药物开发；疫苗研究;预防HIV-1感染。科罗拉多州ACTU将为落基山脉地区提供优秀的艾滋病毒临床研究项目，并将确保来自落基山脉地区受艾滋病毒/艾滋病影响严重的社区的艾滋病毒感染者有机会参与这些研究项目。

DESCRIPTION (provided by applicant): This application is an application for continued funding of the Colorado AIDS Clinical Trials Unit (ACTU) to perform clinical investigations of the pathogenesis and treatment of human immunodeficiency virus type 1 (HIV-1) infection and its complications. The Colorado ACTU will contribute scientific expertise and leadership to the proposed AIDS Clinical Trials Group (ACTG), International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT), and HIV Prevention Trials (HPTN) networks. The Colorado ACTU will be affiliated with the ACTG network and will implement the ACTG scientific agenda at a highly successful and cost-efficient clinical research site located at the University of Colorado Hospital (UCH CRS). Research conducted at the UCH CRS will address the following high priority research areas: Optimization of Clinical Management and Co-Morbidities; Translational Research and Drug Development; Vaccine Research; and Prevention of HIV-1 Infection. The Colorado ACTU will make outstanding HIV clinical research programs available to the Rocky Mountain region and will ensure that HIV-infected people from communities disproportionately affected by HIV/AIDS in the Rocky Mountain region will have the opportunity to participate in these research programs. ADMINISTRATIVE COMPONENT: