UW Clinical HIV Integrated Research Program

描述（由申请人提供）：本提案响应NIH RFA-AI-05-002。它描述了华盛顿大学临床HIV综合研究计划（UW CHIRP）。UW CHIRP的目的是在成人，青少年和儿童中进行示范性的，具有成本效益的艾滋病毒预防和治疗研究。UW CHIRP由四个现有的NIH资助的网络附属HIV临床研究中心（CRS）整合而成。这些CRS是UW HIV预防试验单位（HPTU）CRS，UW艾滋病临床试验单位（ACTU）CRS，UW初级感染诊所（PIC）CRS和UW国际孕产妇儿童青少年艾滋病临床试验（IMPAACT）CRS。一个名为UW临床试验单位（CTU）的行政单位将监督CRS。这四个CRS将分别与艾滋病预防试验网络（HPTN）、艾滋病临床试验组（ACTG）、ACTG和IMPAACT组合作。 UW CHIRP有五个具体目标： 1)组织，整合和协调UW和我们的CRS的基础设施，人员和设施，以最大限度地提高进行网络临床试验的效率和成本效益; 2）确保UW CHIRP的所有要素符合必要的法规要求，并符合每个附属网络的标准; 3）培养新的研究者和临床研究人员，特别是女性和少数民族，并向我们的指导合作伙伴提供我们的临床试验专业知识; 4）为HPTN、ACTG和IMPAACT网络提供科学专业知识，以制定和实施相关的科学议程，并设计协议来支持这些网络的科学议程和研究计划;组织、整合和协调我们的外展工作和与社区的联系，包括继续我们的预防和治疗社区咨询委员会，最大限度地将广泛多样的主题纳入网络协议，包括妇女，种族/少数民族和青年。该提案描述了UW CHIRP每个部分的组织和管理计划;其经验丰富的调查人员的科学专业知识，科学贡献和指导经验;以及社区互动计划，重点是接触妇女，少数民族和青年。报告介绍了三个拟议的国际指导伙伴关系，这些伙伴关系是正在进行的合作的延伸。UW CHIRP汇集了一个富有成效，经验丰富的国内研究人员团队，每个人都为艾滋病毒预防和/或治疗研究做出了重大贡献。通过新的结构，UW CHIRP将增加合作和效率，并将继续为艾滋病毒预防和治疗研究做出重大贡献，以影响全球艾滋病毒/艾滋病流行。 行政部门：

DESCRIPTION (provided by applicant): This proposal responds to NIH RFA-AI-05-002. It describes the University of Washington Clinical HIV Integrated Research Program (UW CHIRP). The purpose of the UW CHIRP is to perform exemplary, cost effective HIV prevention and therapeutic research in adults, adolescents, and children. The UW CHIRP has been formed by integration of four existing, NIH-funded, network-affiliated HIV clinical research sites (CRSs). These CRSs are the UW HIV Prevention Trials Unit (HPTU) CRS, UW AIDS Clinical Trials Unit (ACTU) CRS, UW Primary Infection Clinic (PIC) CRS, and the UW International Maternal Pediatric Adolescent AIDS Clinical Trials (IMPAACT) CRS. An administrative unit called the UW Clinical Trials Unit (CTU) will oversee the CRSs. The four CRSs will collaborate with the HIV Prevention Trials Network (HPTN), AIDS Clinical Trials Group (ACTG), ACTG, and the IMPAACT Group, respectively. UW CHIRP has five specific aims: 1) Organize, integrate, and coordinate the infrastructure, personnel, and facilities of UW and our CRSs to maximize efficiency and cost-effectiveness in conducting Network clinical trials; 2) Ensure that all elements of the UW CHIRP meet necessary regulatory requirements, and perform to the standards of each affiliated Network; 3) Foster new investigators and clinical research staff, especially women and minorities, and provide our clinical trials expertise to our Mentoring Partners; 4) Contribute scientific expertise to the HPTN, ACTG, and IMPAACT Networks to develop and implement relevant scientific agendas, and to design protocols to support these Networks' scientific agendas and research plans; and 5) Organize, integrate, and coordinate our outreach efforts and connections to the community, including continuing our Prevention and Treatment Community Advisory Boards (CABs), to maximize access and enrollment of a broad diversity of subjects into Network protocols, including women, racial/ethnic minorities, and youth. The proposal describes the organization and management plan for each part of UW CHIRP; the scientific expertise, scientific contributions, and mentoring experience of its highly experienced investigators; and the plans for community interactions that will focus on reaching women, minorities and youth. It describes three proposed international Mentoring Partnerships that are extensions of ongoing collaborations. The UW CHIRP brings together a highly productive, experienced team of domestic investigators, each of whom has made a significant contribution to HIV prevention and/or therapeutic research. With the new structure, UW CHIRP will increase collaborations and efficiencies, and will continue to make major contributions to HIV prevention and therapeutic research in order to impact the worldwide HIV/AIDS epidemic. ADMINISTRATIVE COMPONENT: