Analysing the forces, biomechanics and molecular mechanisms that drive cancer metastasis in vitro.

分析体外驱动癌症转移的力、生物力学和分子机制。

• 批准号: 2889258
• 金额: --
• 依托单位: Swansea University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2889258
• 关键词: Analysing; forces; biomechanics; molecular; mechanisms

The project aims to develop novel biomechanical understanding of the differentiation processes undertaken by High Grade Serous Ovarian Carcinoma (HGSOC) cells. The importance of the anomalous mechanical properties of tumour tissues has become increasingly apparent. Indeed, the induction of tumorigenic biochemical signalling, through the reactivation of mechanosensitive pathways in response to pathological mechanical strains, has been shown to correlate with thickening of the tumour extra cellular matrix (ECM), in turn driving tissue stiffening and the construction of physical barriers for both immune cell and therapeutic infiltration. As a result, cancers with excessive ECM deposition are particularly resistant to treatment and immune cell surveillance, linking biomechanics to prevalent clinical challenges. Greater understanding of these process requires innovative technology development.

该项目旨在对高级别浆液性卵巢癌（HGSOC）细胞的分化过程进行新的生物力学理解。肿瘤组织的异常力学性质的重要性已变得越来越明显。事实上，通过对病理性机械应变的机械敏感通路的再激活，诱导致瘤性生化信号已被证明与肿瘤细胞外基质（ECM）增厚相关，进而驱动组织硬化和免疫细胞和治疗性浸润的物理屏障的构建。因此，过度ECM沉积的癌症对治疗和免疫细胞监测特别有抵抗力，将生物力学与普遍的临床挑战联系起来。更好地理解这些过程需要创新技术的发展。