Systems Engineering of Pheresis Intervention for Sepsis

描述(由申请人提供)： 为了响应：PAR-04-023，我们建议建立生物工程研究伙伴关系，以设计和测试一种基于血液吸附原理的用于治疗严重脓毒症的体外装置。我们的多学科团队包括基础科学和临床研究人员、生物工程和生物材料专家以及复杂系统建模专家。我们的计划将仔细整合这一来自技术和生物医学领域的不同研究人员群体，跨越多个科学学科的边界，并利用工业界和学术界的能力。我们的项目名为脓毒症(脓毒症)的系统工程干预。 严重脓毒症(感染引起的急性器官衰竭)是一个主要的健康问题，每年导致近25万美国人死亡，花费数十亿美元。现有的脓毒症治疗方法，包括最近批准的那些，都是次优的，迫切需要新的治疗方法。然而，炎症反应网络的复杂性和临床试验的高昂成本，特别是在危重病人中，使传统的药物/设备开发范例过时。我们之前已经开发并测试了一种用于治疗慢性肾脏疾病的体外血液净化设备，并将该设备用于治疗急性炎症性疾病。我们还开发了一个脓毒症的数学模型，并对其进行了部分校准--在啮齿动物和人类身上都是如此。该项目建议整合这两项成果，并通过迭代设计过程，开发一种可用于治疗严重脓毒症的设备。 这项建议的目标是设计一种用于治疗严重脓毒症的体外血液净化装置。这项提案将汇集匹兹堡大学下列系的研究人员：生物工程、化学工程、重症监护医学、外科、医学和数学。我们还将邀请两家公司的专业知识，一家专门从事吸附聚合物技术(MedaSorb Technologies，LLC)，另一家专门从事复杂系统建模(免疫系统公司)。

DESCRIPTION (provided by applicant): In response to: PAR-04-023, we are proposing a Bioengineering Research Partnership to design and test an extracorporeal device for the treatment of severe sepsis, based on the principle of hemoadsorption. Our multidisciplinary team comprises basic science and clinical researchers, bioengineering and biomaterials experts, and experts in complex systems modeling. Our proposal will carefully integrate this diverse group of researchers from both technical and biomedical fields, crossing the boundaries of multiple scientific disciplines and leveraging the capabilities of both industry and academia. Our project is entitled Systems Engineering of a Pheresis Intervention for Sepsis (SEPsIS). Severe sepsis (acute onset organ failure in the setting of infection) is a major health problem that kills nearly 250,000 Americans each year and costs billions of dollars. Available therapies for sepsis, including those recently approved, are suboptimal and new therapies are urgently needed. However, the complexities of the inflammatory response network and the high cost of clinical trials, particularly in the critically ill, renders the traditional drug/device development paradigm obsolete. We have previously developed and tested an extracorporeal blood purification device for treatment in chronic renal disease and have adapted this device for the treatment of acute inflammatory diseases. We have also developed and partially calibrated-in both rodents and humans-a mathematical model of sepsis. This project proposes to integrate these two achievements and, through an iterative design process, develop a device that can be used to treat severe sepsis. The goal of this proposal is to design an extracorporeal blood purification device for the treatment of severe sepsis. This proposal will bring together investigators from the following departments at the University of Pittsburgh: Bioengineering, Chemical Engineering, Critical Care Medicine, Surgery, Medicine, and Mathematics. We will also call on the expertise of two companies, one specializing in adsorbent polymer technology (MedaSorb Technologies, LLC) and the other in complex systems modeling (Immunetrics, Inc.).