Reactive Oxygen Species American Society of Nephrology Fall 2007

描述（由申请人提供）：特别是在过去的十年中，活性氧（ROS）和自由基生物学在生物医学研究界引起了极大的兴趣。这导致了研究数量的指数增加，重点是它们在细胞防御，细胞信号传导，细胞凋亡，衰老，高血压，动脉粥样硬化，氧传感，炎症和纤维化中的作用。这一研究领域特别困难，因为各种ROS如超氧化物、过氧化氢、次氯酸、羟基自由基和一氧化氮是与蛋白质、脂质、核酸和彼此反应的短寿命分子。这通过复杂的化学反应发生在细胞微区中。特别困难的问题，目前自己的研究，因为检测ROS的方法是困扰与特异性差的问题。分子生物学也很复杂，因为细胞已经进化出许多专门用于产生、转化和消耗ROS的机制。这些大分子包括NADPH氧化酶、超氧化物歧化酶、过氧化氢酶和血红素加氧酶的多种同工型。此外，外源性物质如维生素C和D可以与这些细胞酶协同作用以抑制自由基。本次会议旨在汇集世界各地的专家，提供从ROS的定义到其检测，细胞机制和各种生物学作用的逻辑进展。我们的总体目标是为参加并列的美国肾脏病学会会议的年轻科学家提供部分支持，也参加这个为期两天的会议。年轻科学家的出席确保了这些信息将被转化为未来的研究，阐明ROS在肾脏疾病及其治疗中的作用。

DESCRIPTION (provided by applicant): Particularly throughout the last decade, Reactive Oxygen Species (ROS) and the biology of free radicals have attracted great interest in the biomedical research community. This has led to an exponential increase in the number of studies focused on their role in cellular defense, cell signaling, apoptosis, aging, hypertension, atherosclerosis, oxygen sensing, inflammation and fibrosis. This area of research is particularly difficult because various ROS such as superoxide, hydrogen peroxide, hypochlorous acid, hydroxyl radical and nitric oxide are short lived molecules that react with proteins, lipids, nucleic acids and one another. This occurs within cellular microdomains through complex chemical reactions. Particularly difficult issues present themselves to investigators because methods for detection of ROS are plagued with problems of poor specificity. The molecular biology is also complex because cells have evolved much machinery dedicated to generation, conversion and consumption of ROS. These macromolecules include multiple isoforms of NADPH oxidases, superoxide dismutases, catalase and hemoxygenase. Furthermore, exogenous substances such as Vitamin C and D can act in concert with those cellular enzymes to scavenge free radicals. This conference has been designed to bring together world experts to provide talks that logically progress from definition of ROS to their detection, cellular machinery and various biological roles. Our general goal is to provide partial support for young scientists attending the juxtaposed American Society of Nephrology meeting to also attend this two day conference. Attendance of young scientists insures that the information will be translated into future studies that elucidate the role of ROS in kidney diseases and treatment thereof.