Training Grant in Cardiac and Vascular Cell Biology

心脏和血管细胞生物学培训补助金

• 批准号: 7017081
• 负责人: THOMAS L PALLONE
• 金额: $ 32.82万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7017081
• 关键词: Training; Grant; Cardiac; Vascular; Cell

DESCRIPTION (provided by applicant): This program provides interdisciplinary training in cardiac and vascular cell biology for pre- and postdoctoral students. The program emphasizes the functional properties of cardiac and vascular smooth muscle. Our primary faculty members are from 4 departments/divisions of the University of Maryland School of Medicine and the University of Maryland Biotechnology Institute. Reflecting the diversity of faculty backgrounds, the training opportunities are broad and include: the molecular determinants of cardiac and vascular smooth muscle function, molecular structure and function studies of cardiac and vascular smooth muscle proteins, the cell biology of the cytoskeleton and extracellular matrix of cardiac and vascular smooth muscle, the biophysical and physiological analysis of the function of individual cardiac and vascular smooth muscle cells and endothelial cells, and the biomechanical properties of whole tissues and intact organs. Our faculty enjoys a national and international reputation in the study of calcium homeostasis in cardiac and vascular smooth muscle. Our students receive training in these and a variety of related areas including the molecular and functional control of muscle gone expression with emphasis on the use of several complementary techniques to approach each question under investigation. The major aspects of the didactic training consists of two interdisciplinary courses on muscle biology, courses in molecular biology and functional genomics offered by the Center's faculty. We propose 4 predoctoral and 4 postdoctoral trainees for each year of the training program. Entering predoctoral trainees will have a solid background in biology, chemistry and/or physics, excellent GRE scores, research experience and strong letters of recommendation. Incoming postdoctoral trainees will have completed a solid Ph.D. thesis and have strong letters of recommendation. Trainees completing this program will be prepared to bring a wide range of methodological approaches to bear on basic questions in normal cardiac and vascular cell biology, on the underlying mechanisms responsible for a variety of cardiac and vascular pathologies, and on their possible cure and prevention. Therefore, the program fills a national need for expert investigators with multidisciplinary training who can focus on cardiac and vascular muscle biology.

描述（由申请人提供）： 该计划为学前和博士后学生提供心脏和血管细胞生物学的跨学科培训。 该计划强调心脏和血管平滑肌的功能特性。 我们的主要教职员工来自马里兰大学医学院和马里兰州生物技术学院的四个部门/部门。 反映教师背景的多样性，训练机会很广，包括：心脏和血管平滑肌功能的分子决定因素，心脏和血管平滑肌蛋白的分子结构以及功能研究，细胞骨架的细胞生物学，心脏和血管平滑肌肉和血管平滑肌肉，生物学和物理学和物理学的功能和物理学分析，生物学平滑肌肉和物理学的功能，并存在于生物学上。内皮细胞以及整个组织和完整器官的生物力学特性。 我们的教师在心脏和血管平滑肌中钙稳态研究中享有国家和国际声誉。 我们的学生接受了这些和各种相关领域的培训，包括对肌肉表达的分子和功能控制，重点是使用几种互补技术来解决每个正在研究的问题。 教学培训的主要方面包括有关肌肉生物学的两种跨学科课程，该中心教职员工提供的分子生物学课程和功能基因组学课程。 我们为培训计划的每一年提出了4个占主导地位和4名博士后学员。进入毒物前学员将在生物学，化学和/或物理学，出色的GRE分数，研究经验和强有力的推荐信方面具有扎实的背景。传入的博士后学员将完成固体博士学位。论文并有强有力的推荐信。 完成该计划的学员将准备好采用多种方法论方法来承担正常心脏和血管细胞生物学中的基本问题，基于负责各种心脏和血管病理学的基本机制，以及可能的治愈和预防。 因此，该计划填补了国家 需要接受多学科培训的专家研究人员，他们可以专注于心脏和血管肌肉生物学。