2007 Elastin and Elastic Fibers Gordon Conference

2007 年弹性蛋白和弹性纤维戈登会议

• 批准号: 7273933
• 负责人: Elaine C Davis
• 金额: $ 2.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273933
• 关键词: Award; Biocompatible Materials; Biological Assay; Biology; Caenorhabditis elegans; Cells; Collaborations; Data; Depth; Development; Discipline; Disease; Elastic Fiber; Elastin; Homeostasis; In Vitro; Investigation; Lead; Light; Modeling; Participant; Play; Prize; Protein-Lysine 6-Oxidase; Proteins; Proteoglycan; Recording of previous events; Research; Research Personnel; Resolution; Respiratory physiology; Role; Skin; Structure; Time; Tissue Engineering; Tissues; Transgenic Organisms; Xenopus; Zebrafish; body system; fibrillin; fibulin; human disease; in vivo; insight; knockout animal; latent TGF-beta binding protein; novel; posters; size; success; symposium

DESCRIPTION (provided by applicant): The Elastin and Elastic Fibers GRC originated in 1979 and has a distinguished history as the leading forum for the development of new ideas on the mechanism of elastic fiber assembly and role that elastic fibers play in tissue homeostasis and disease. The Conference is unique in the depth of its coverage of elastin biology, spanning from detailed, high-resolution structural studies of elastin and fibrillin, to in vitro assembly assays, to functional in vivo research with transgenic and knockout animals, to human disease, and finally to biomaterials and therapies. Over the past decade, the breadth of the Conference has also exploded with the identification and study of numerous elastic fiber-associated proteins, such as the fibulins, latent TGF-beta binding proteins, emilins, proteoglycans and lysyl oxidases. Research on these proteins has emphasized the complexity of the elastic fiber and highlighted the need for new collaborative studies between the biochemists, cell biologists and clinicians in the field. The 2007 Conference will focus on the most recent, exciting developments in the field from the past two years and stimulate discussion among the participants from diverse disciplines and backgrounds. Traditional sessions on elastin and fibrillin structure and assembly, and on tissue engineering of elastogenic materials will be included, however, new to the 2007 Conference will be the incorporation of this research into distinct sessions that revolve around specific organ systems where elastin is critical for structure and function: lung, vasculature and skin. Also new to the 2007 Conference, will be a session on alternative models to study elastic fiber proteins, including zebrafish, Xenopus and C. elegans. In each morning session, time will be allocated to highlight 3 posters so as to emphasize the exciting research presented by our young researchers at the two poster sessions. To further encourage these young people, 3 poster prizes will be awarded at the final session. Overall, the GRC format differs from almost all other scientific meetings in that it provides an extensive opportunity for open, free and informal discussion. The success of each Conference is attributable to the participation of leaders in the field, new ideas and insight from young investigators, the presentation of unpublished data, engaging formal and informal discussions, and limited size and geographical isolation. In light of the success of past Elastin and Elastic Fiber GRCs, there is no question that the research presented and the discussions that will ensue at the 2007 Conference will lead to new and productive collaborations that will advance the field and uncover novel avenues of elastic fiber investigation.

描述（由申请人提供）： 弹性蛋白和弹性纤维GRC起源于1979年，具有悠久的历史， 领先的论坛，对弹性纤维组装和作用的机制的新思想的发展 弹性纤维在组织平衡和疾病中的作用。本会议的独特之处在于其 弹性蛋白生物学的覆盖面，从弹性蛋白的详细，高分辨率的结构研究， 转基因和基因敲除动物的体内功能研究， 到人类疾病，最后到生物材料和治疗。在过去的十年里， 会议还爆发了许多弹性纤维相关的鉴定和研究 蛋白质，如纤蛋白、潜伏性TGF-β结合蛋白、emilins、蛋白聚糖和赖氨酰 氧化酶对这些蛋白质的研究强调了弹性纤维的复杂性， 强调了生物化学家，细胞生物学家和 临床医生在现场。 2007年会议将重点讨论过去两年来该领域最新的令人兴奋的发展，并鼓励来自不同学科和背景的与会者进行讨论。关于弹性蛋白和弹性蛋白结构和组装以及组织的传统会议 弹性材料的工程将包括在内，然而，2007年会议的新内容将是 将这项研究纳入围绕特定器官系统的不同会议中， 弹性蛋白对于肺、脉管系统和皮肤的结构和功能至关重要。也是2007年新推出的 会议，将是一个关于替代模型的会议，以研究弹性纤维蛋白，包括斑马鱼， Xenopus和C.优美的在每天上午的会议中，将分配时间突出3张海报， 强调我们的年轻研究人员在两次海报会议上提出的令人兴奋的研究。到 为了进一步鼓励这些年轻人，最后一节将颁发3个海报奖。 总的来说，GRC的形式与几乎所有其他科学会议不同，因为它提供了广泛的机会进行公开，自由和非正式的讨论。每次会议的成功都归功于该领域领导人的参与、年轻调查人员的新想法和见解、未发表数据的介绍、开展正式和非正式讨论以及规模有限和地理位置偏远。鉴于过去弹性蛋白和弹性纤维GRCs的成功，毫无疑问，在2007年会议上提出的研究和随后的讨论将导致新的和富有成效的合作，这将推动该领域的发展，并揭示弹性纤维研究的新途径。