2007 Elastin and Elastic Fibers Gordon Conference

描述(由申请人提供)： 弹性蛋白和弹性纤维GRC起源于1979年，作为 开发关于弹性纤维组装机制和作用的新想法的领导论坛 弹性纤维在组织动态平衡和疾病中发挥作用。会议在其深度方面是独一无二的 弹性蛋白生物学的报道，涵盖弹性蛋白和弹性蛋白的详细、高分辨率结构研究 纤维蛋白，到体外组装试验，到转基因和基因敲除动物的体内功能研究， 到人类疾病，最后到生物材料和疗法。在过去的十年里， 会议上还爆发了许多与弹性纤维相关的识别和研究 蛋白质，如纤维蛋白、潜在的转化生长因子-β结合蛋白、外膜蛋白、蛋白多糖和赖氨酸 氧化物酶。对这些蛋白质的研究强调了弹性纤维和 强调了生物化学家、细胞生物学家和 该领域的临床医生。2007年会议将侧重于过去两年来该领域最新、最令人振奋的事态发展，并鼓励来自不同学科和背景的与会者进行讨论。关于弹性蛋白和纤维蛋白结构和组装以及组织的传统会议 弹性材料工程将包括在内，然而，2007年会议的新内容将是 将这项研究纳入围绕特定器官系统的不同会议，其中 弹性蛋白对肺、血管和皮肤的结构和功能至关重要。同样是2007年的新产品 会议将是关于研究弹性纤维蛋白质的替代模型的会议，包括斑马鱼， 非洲爪哇和线虫。在每个上午的会议中，将分配时间突出3张海报，以便 强调我们的年轻研究人员在两个海报会议上展示的令人兴奋的研究。至 进一步鼓励这些年轻人，将在最后一届会议上颁发3张海报奖。总体而言，GRC的形式与几乎所有其他科学会议的不同之处在于，它为公开、自由和非正式的讨论提供了广泛的机会。每一次会议的成功都归功于实地领导人的参与、年轻研究人员的新想法和见解、提出未公布的数据、进行正式和非正式讨论以及规模有限和地理孤立。鉴于过去弹性蛋白和弹性纤维GRC的成功，毫无疑问，在2007年会议上提出的研究和随后的讨论将导致新的和富有成效的合作，这些合作将推动该领域的发展，并揭示弹性纤维研究的新途径。

DESCRIPTION (provided by applicant): The Elastin and Elastic Fibers GRC originated in 1979 and has a distinguished history as the leading forum for the development of new ideas on the mechanism of elastic fiber assembly and role that elastic fibers play in tissue homeostasis and disease. The Conference is unique in the depth of its coverage of elastin biology, spanning from detailed, high-resolution structural studies of elastin and fibrillin, to in vitro assembly assays, to functional in vivo research with transgenic and knockout animals, to human disease, and finally to biomaterials and therapies. Over the past decade, the breadth of the Conference has also exploded with the identification and study of numerous elastic fiber-associated proteins, such as the fibulins, latent TGF-beta binding proteins, emilins, proteoglycans and lysyl oxidases. Research on these proteins has emphasized the complexity of the elastic fiber and highlighted the need for new collaborative studies between the biochemists, cell biologists and clinicians in the field. The 2007 Conference will focus on the most recent, exciting developments in the field from the past two years and stimulate discussion among the participants from diverse disciplines and backgrounds. Traditional sessions on elastin and fibrillin structure and assembly, and on tissue engineering of elastogenic materials will be included, however, new to the 2007 Conference will be the incorporation of this research into distinct sessions that revolve around specific organ systems where elastin is critical for structure and function: lung, vasculature and skin. Also new to the 2007 Conference, will be a session on alternative models to study elastic fiber proteins, including zebrafish, Xenopus and C. elegans. In each morning session, time will be allocated to highlight 3 posters so as to emphasize the exciting research presented by our young researchers at the two poster sessions. To further encourage these young people, 3 poster prizes will be awarded at the final session. Overall, the GRC format differs from almost all other scientific meetings in that it provides an extensive opportunity for open, free and informal discussion. The success of each Conference is attributable to the participation of leaders in the field, new ideas and insight from young investigators, the presentation of unpublished data, engaging formal and informal discussions, and limited size and geographical isolation. In light of the success of past Elastin and Elastic Fiber GRCs, there is no question that the research presented and the discussions that will ensue at the 2007 Conference will lead to new and productive collaborations that will advance the field and uncover novel avenues of elastic fiber investigation.