Lipid Droplets: Metabolic Consequences of Stored Neutral Lipids

描述(由申请人提供)： FASEB关于脂滴：储存中性脂类的代谢后果的夏季会议将汇集来自不同领域的科学家，目的是定义、描述和分析关键的科学问题和脂滴的细胞生物学、生物化学和生理学方面的最新进展。小型的会议形式和与世隔绝的会议场地将营造一个亲密和互动的环境，在这个环境中，初级调查人员，包括研究生、博士后研究员和初级教员，将有足够的机会与更资深的成熟调查人员互动。这将是第一次聚焦于脂滴生物学的会议，这是一个迅速发展的研究领域。会议形式将把从事这一新兴领域不同方面工作的科学家聚集在一起，但他们以前没有参加过相同的会议，目的是产生新的想法、方法和合作。该申请要求提供部分资金，以支持10名研究生和博士后研究员参加2007年7月28日至8月2日在佛蒙特州萨克斯顿河的佛蒙特州学院举行的会议。开幕式将包括杰拉尔德·I·舒尔曼博士关于三酰甘油储存和II型糖尿病发病机制的开幕之夜的主旨演讲。与4位发言者的八次会议将集中在活跃的研究领域：1)中性脂合成底物的传递和代谢，2)中性脂的合成和储存，3)三酰甘油储存的脂解和通量，4)脂滴的结构蛋白，包括PAT家族蛋白和油球蛋白，5)脂代谢和储存 包括细菌、线虫、果蝇和斑马鱼在内的各种生物，6)作为参与蛋白质和脂类运输的动态隔室的脂滴，7)脂滴的细胞生物学，以及8)储存中性脂的新陈代谢结果。两个为期两天的海报会议将允许更多的研究人员，包括研究生和博士后研究员，展示他们的研究供非正式讨论。已预留5个发言者职位，供从招贴式会议提交的摘要和新出现的“热门专题”中挑选；将优先为其馀发言者职位挑选初级调查员。

DESCRIPTION (provided by applicant): The FASEB Summer Conference on Lipid Droplets: Metabolic Consequences of Stored Neutral Lipids will bring together scientists from a variety of fields with the purpose of defining, describing, and analyzing critical scientific problems and recent advances in the cell biology, biochemistry, and physiology of lipid droplets. The small conference format and secluded conference site will foster an intimate and interactive environment in which junior investigators, including graduate students, postdoctoral fellows, and junior faculty, will have ample opportunity to interact with more senior established investigators. This will be the first conference to focus on the biology of lipid droplets, a rapidly developing field of investigation. The meeting format will bring together scientists working on diverse and varied aspects of this emerging field, but who have not previously attended the same conferences, with the goal of generating new ideas, approaches, and collaborations. The application requests partial funding to support the participation of 10 graduate students and postdoctoral fellows in a conference to be held July 28 - August 2, 2007 at Vermont Academy in Saxtons River, VT. The format will include an opening night Keynote Address by Dr. Gerald I. Shulman on triacylglycerol storage and the pathogenesis of Type II Diabetes. Eight sessions of talks with 4 speakers each will focus on active areas of research: 1) Delivery and metabolism of substrates for neutral lipid synthesis, 2) Synthesis and storage of neutral lipids, 3) Lipolysis and flux of triacylglycerol stores, 4) Structural proteins of lipid droplets including PAT family proteins and oleosins, 5) Lipid metabolism and storage in diverse organisms including bacteria, C. elegans, Drosophila, and zebrafish, 6) Lipid droplets as a dynamic compartment involved in trafficking of proteins and lipids, 7) Cell biology of lipid droplets, and 8) Metabolic consequences of stored neutral lipids. Two 2-day poster sessions will allow additional investigators, including graduate students and postdoctoral fellows, to present their research for informal discussion. Five speaker positions have been reserved for talks to be selected from abstracts submitted for the poster session and emerging "hot topics"; preference will be given to the selection of junior investigators for the remaining speaker positions.