Lipid Droplets: Metabolic Consequences of Stored Neutral Lipids

脂滴：储存的中性脂质的代谢后果

• 批准号: 7329013
• 负责人: DAWN L BRASAEMLE
• 金额: $ 1.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7329013
• 关键词: Academy; Address; Area; Bacteria; Biochemistry; Biology; Caenorhabditis elegans; Cellular biology; Collaborations; Drosophila genus; Environment; Faculty; Fostering; Funding; Goals; Investigation; Lipids; Lipolysis; Metabolic; Metabolism; Non-Insulin-Dependent Diabetes Mellitus; Organism; Pathogenesis; Physiology; Positioning Attribute; Postdoctoral Fellow; Protein Family; Purpose; Request for Applications; Research; Research Personnel; Rivers; Scientist; Site; Structural Protein; Students; Triglycerides; Vermont; Work; Zebrafish; abstracting; day; intracellular protein transport; lipid metabolism; posters; preference; protein transport; symposium

DESCRIPTION (provided by applicant): The FASEB Summer Conference on Lipid Droplets: Metabolic Consequences of Stored Neutral Lipids will bring together scientists from a variety of fields with the purpose of defining, describing, and analyzing critical scientific problems and recent advances in the cell biology, biochemistry, and physiology of lipid droplets. The small conference format and secluded conference site will foster an intimate and interactive environment in which junior investigators, including graduate students, postdoctoral fellows, and junior faculty, will have ample opportunity to interact with more senior established investigators. This will be the first conference to focus on the biology of lipid droplets, a rapidly developing field of investigation. The meeting format will bring together scientists working on diverse and varied aspects of this emerging field, but who have not previously attended the same conferences, with the goal of generating new ideas, approaches, and collaborations. The application requests partial funding to support the participation of 10 graduate students and postdoctoral fellows in a conference to be held July 28 - August 2, 2007 at Vermont Academy in Saxtons River, VT. The format will include an opening night Keynote Address by Dr. Gerald I. Shulman on triacylglycerol storage and the pathogenesis of Type II Diabetes. Eight sessions of talks with 4 speakers each will focus on active areas of research: 1) Delivery and metabolism of substrates for neutral lipid synthesis, 2) Synthesis and storage of neutral lipids, 3) Lipolysis and flux of triacylglycerol stores, 4) Structural proteins of lipid droplets including PAT family proteins and oleosins, 5) Lipid metabolism and storage in diverse organisms including bacteria, C. elegans, Drosophila, and zebrafish, 6) Lipid droplets as a dynamic compartment involved in trafficking of proteins and lipids, 7) Cell biology of lipid droplets, and 8) Metabolic consequences of stored neutral lipids. Two 2-day poster sessions will allow additional investigators, including graduate students and postdoctoral fellows, to present their research for informal discussion. Five speaker positions have been reserved for talks to be selected from abstracts submitted for the poster session and emerging "hot topics"; preference will be given to the selection of junior investigators for the remaining speaker positions.

描述（由申请人提供）： FASEB脂质滴夏季会议：储存中性脂质的代谢后果将汇集来自各个领域的科学家，旨在定义，描述和分析关键的科学问题以及细胞生物学，生物化学和生理学的最新进展。小型会议形式和隐蔽的会议场地将培养一个亲密和互动的环境，其中初级研究人员，包括研究生，博士后研究员和初级教师，将有充分的机会与更资深的研究人员互动。这将是第一次关注脂滴生物学的会议，这是一个快速发展的研究领域。会议形式将汇集科学家在这个新兴领域的不同和不同方面的工作，但谁以前没有参加过相同的会议，以产生新的想法，方法和合作的目标。申请要求部分资金，以支持10名研究生和博士后研究员参加将于2007年7月28日至8月2日在佛蒙特州萨克顿河佛蒙特学院举行的会议。该格式将包括一个开幕之夜的主题演讲博士杰拉尔德我。舒尔曼对三酰甘油储存和II型糖尿病的发病机制。八场讲座，每场四位演讲者将专注于活跃的研究领域：1）中性脂质合成底物的传递和代谢，2）中性脂质的合成和储存，3）三酰甘油储存的脂解和流动，4）脂滴的结构蛋白，包括PAT家族蛋白和油质蛋白，5）脂质代谢和储存， 包括细菌、C.线虫、果蝇和斑马鱼，6）作为参与蛋白质和脂质运输的动态区室的脂滴，7）脂滴的细胞生物学，和8）储存的中性脂质的代谢结果。两个为期2天的海报会议将允许更多的研究人员，包括研究生和博士后研究员，介绍他们的研究进行非正式讨论。已为演讲预留了五个发言人职位，将从为海报会议提交的摘要和新出现的“热点专题”中选出;将优先选择初级调查员担任其余发言人职位。