Stress Proteins in Growth, Development & Disease 2007Gordon Research Conference

生长、发育过程中的应激蛋白

• 批准号: 7320999
• 负责人: Peter Walter
• 金额: $ 1.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7320999
• 关键词: Aging; Alzheimer' s Disease; Autophagocytosis; Biological Models; California; Cardiovascular Diseases; Cell Death; Cells; Cellular biology; Condition; Development; Disease; Functional disorder; Gene Expression; Genes; Growth and Development function; Health; Heat shock proteins; Homeostasis; Human; Huntington Disease; Infection; Inflammation; Intention; Lead; Longevity; Malignant Neoplasms; Metabolic; Metabolism; Modeling; Molecular; Organism; Oxidative Stress; Pathway interactions; Physiological; Postdoctoral Fellow; Prions; Production; Protein Conformation; Protein-Folding Disease; Proteins; Reaction; Regulation; Request for Applications; Research; Research Personnel; Role; San Francisco; Signal Transduction; Signal Transduction Pathway; Stress; Students; System; Temperature; Time; Transcription factor genes; Universities; Woman; base; biological adaptation to stress; college; human disease; irradiation; posters; protein function; protein misfolding; stress protein; symposium; transmission process

DESCRIPTION (provided by applicant): GRC on Stress Proteins in Growth, Development and Disease All organisms are exposed to stressful conditions including environmental stresses such as elevated temperatures and irradiation, physiological stress such as oxidative stress due to metabolic reactions, or pathophysiological stresses such as pharmacological agents, infection and inflammation. These stressful conditions lead to protein misfolding, aggregation, cellular dysfunction and cell death. Recent studies strongly suggest that the ability to sense and respond to stress signals, through the activation of signal transduction pathways, transcription factors and gene productions that function in protein homeostasis is critical for normal growth, development and in the protection against diseases that include cancer, cardiovascular disease and protein folding diseases such as Alzheimer's Huntington's and prion-based disease. Furthermore, studies in model systems have established a strong correlation between longevity and the ability to mount robust stress responses. The meeting will highlight the many cutting- edge advances in the field, including the mounting appreciation of the importance of autophagy pathways to remodel cells under stress conditions and the increasing emphasis on using modeling approaches to understand stress regulation at a systems level. This Gordon Research Conference on "Stress Proteins in Growth, Development and Disease" will be held August 19-24, 2007 at Magdelan College in Oxford, UK. The organizers are Peter Walter, Chair (University of California, San Francisco), and Bernd Bukau, Vice-Chair (Universit¿t Heidelberg, Zentrum f¿r Molekulare Biologie). We will emphasize vigorous discussions of recent developments in stress sensing, signaling and gene expression, diseases of protein conformation, roles of stress genes in metabolism, growth and development, stress gene modulation of infection, the cell biology of stress and the roles of stress in aging. Eight sessions are planned, most with speaking opportunities reserved for new investigators, trainees and recent breakthroughs. All 33 speakers invited to date, of which 42% are women, have confirmed their intention to attend. There will be abundant opportunities for detailed, informal discussions among speakers, postdoctoral fellows and graduate students at poster sessions and additional times during the meeting to enhance interactions and information transmission. This application requests partial support for this Gordon Research Conference. GRC on Stress Proteins in Growth, Development and Disease This meeting will enhance our understanding of stress signaling, stress protein function and mechanism of action, and the role of stress in human health, disease and in aging. Cells employ various mechanisms that help protect them from stresses to which all organisms are constantly exposed, including environmental stresses such as elevated temperatures and irradiation, physiological stress such as oxidative stress due to metabolic reactions, or pathophysiological stresses such as pharmacological agents, infection and inflammation. The molecular consequences of such stressful conditions are protein misfolding, cellular dysfunction, and cell death, manifesting itself as aging and a multitude of human diseases.

描述（由申请人提供）： 所有生物体都暴露在应激条件下，包括环境应激（如高温和辐射）、生理应激（如代谢反应引起的氧化应激）或病理生理应激（如药物、感染和炎症）。这些应激条件导致蛋白质错误折叠、聚集、细胞功能障碍和细胞死亡。最近的研究强烈地表明，通过激活在蛋白质稳态中起作用的信号转导途径、转录因子和基因产生来感知和响应压力信号的能力对于正常生长、发育和预防包括癌症、心血管疾病和蛋白质折叠疾病（例如阿尔茨海默氏病（Alzheimer's）亨廷顿病和朊病毒疾病）在内的疾病至关重要。此外，在模型系统中的研究已经建立了长寿和建立强大的压力反应的能力之间的强相关性。会议将突出该领域的许多前沿进展，包括越来越多地认识到自噬途径在压力条件下重塑细胞的重要性，以及越来越重视使用建模方法来理解系统水平上的压力调节。戈登研究会议将于2007年8月19日至24日在英国牛津大学马格德兰学院举行，主题是“生长、发育和疾病中的应激蛋白”。组织者是Peter Walter，主席（加州大学，旧金山弗朗西斯科）和Bernd Bukau，副主席（海德堡大学，分子生物中心）。我们将着重讨论压力传感，信号和基因表达，蛋白质构象的疾病，压力基因在代谢，生长和发育中的作用，压力基因对感染的调节，压力的细胞生物学和压力在衰老中的作用的最新发展。计划举行八次会议，大多数会议都为新的调查人员、受训人员和最近的突破保留发言机会。迄今为止，所有33位受邀发言者（其中42%为女性）均已确认有意出席。将有大量的机会在海报会议上和会议期间的其他时间进行演讲者、博士后研究员和研究生之间的详细非正式讨论，以加强互动和信息传播。此应用程序请求部分支持此戈登研究会议。GRC on Stress Proteins in Growth，Development and Disease本次会议将加深我们对压力信号、压力蛋白功能和作用机制以及压力在人类健康、疾病和衰老中的作用的理解。细胞采用各种机制来帮助保护它们免受所有生物体不断暴露的应激，包括环境应激如升高的温度和辐射，生理应激如由于代谢反应引起的氧化应激，或病理生理应激如药理学试剂，感染和炎症。这种应激条件的分子后果是蛋白质错误折叠、细胞功能障碍和细胞死亡，表现为衰老和多种人类疾病。