2007 Polyamines Gordon Conference and Graduate Research Seminar

多胺戈登会议将于6月17日至18日在新罕布什尔州的沃特维尔山谷举行。 2007年22日。多胺在所有细胞中都是必需的，因此多胺场是多样的， 包括微生物和多细胞真核生物的研究。尽管它们很重要， 我们仍然没有完全了解多胺的细胞功能，许多生物学仍然有待于研究。 阐明。多胺与细胞生长密切相关，因此多胺的抑制剂 作为抗增殖剂促进生物合成。传统上，这些抑制剂被严重地 作为抗癌剂进行研究，然而，这些抑制剂最成功的应用是作为 抗寄生虫药多胺在转录、翻译和蛋白质水平上受到高度调控 周转因此，该领域汇集了对多胺的生理作用感兴趣的研究， 各种各样的生物（哺乳动物细胞，酵母，原生动物和细菌）和研究人员感兴趣， 从癌症生物学到原生动物和细菌病原体的治疗应用。其中后者 对全球健康产生独特而重大的影响。会议将包括一系列 由与会者进行30分钟或10分钟的演讲，然后进行广泛的讨论。它还将 包括为学生和博士后研究员举办海报展示会，介绍他们工作。为进一步 鼓励学生和博士后科学家参加会议，多胺GRC 将与戈登-凯南研究生/博士后多胺研究研讨会一起举行。 GKGRS将于6月15日至17日在沃特维尔山谷举行，学生/博士后 参加GKGRS的人也将参加定期的GRC会议。议题 讨论将包括：微生物中的多胺代谢和分解代谢途径， 真核细胞，多胺通路调控，系统生物学，药物发现和抑制剂 设计

The Polyamines Gordon conference will be held in Waterville Valley, New Hampshire from June 17- 22, 2007. Polyamines are essential in all cells, and as such the polyamine field is diverse and encompasses the study of both microorganisms and multicellular eukaryotes. Despite their importance, we still do not fully understand the cellular function of polyamines, and much biology remains to be elucidated. Polyamines are closely linked to cell growth, and as such inhibitors of polyamine biosynthesis are promoted as anti-proliferative agents. Traditionally these inhibitors have been heavily investigated as anti-cancer agents, however the most successful application of these inhibitors is as anti-parasitics. Polyamines are highly regulated at the levels of transcription, translation and protein turnover. Thus the field brings together researches interested in the physiological role of Polyamines in a wide array of organisms (mammalian cells, yeast, protozoa and bacteria) and researchers interested in therapeutic applications from Cancer biology, to protozoal and bacterial pathogens. The latter of which have a unique and significant Global Health impact. The meeting will be composed of a series of either 30 min or 10 min talks given by meeting participants, followed by extensive discussion. It will also include poster sessions for student and postdoctoral fellows to present their work. In order to further encourage the participation of student and postdoctoral scientists in the meeting, the Polyamine GRC will be held in conjunction with a Gordon-Kenan Graduate/Post-Doc Research Seminar on polyamines. The GKGRS will be held from June 15-17, also at Waterville Valley, and students/postdocs participating in the GKGRS will be expected to also attend the regular GRC meeting. Topics for discussion will include: Polyamine metabolic and catabolic pathways in microorganisms and eukaryotic cells, regulation of polyamine pathways, systems biology, drug discovery and inhibitor design.