Gordon Conference on "Phosphorylation and G Protein Signaling Networks"

描述（由申请人提供）： 我们请求部分资金支持磷酸化和G蛋白信号网络戈登研究会议（GRC）的运作。这个会议，以前称为“第二信使和蛋白质磷酸化”自1970年以来每年举行一次，并已成为介绍信号转导新发现的主要场所。从一开始就发起并参加这次会议的研究人员是建立信号转导领域的领导者，包括几位获得诺贝尔奖的人（例如，Earl Sutherland，Al Oilman，Stanley Cohen，Edwin Krebs，Edmond Fischer，Paul Nurse）。会议的重点是调节细胞生长，分化，存活和代谢的信号转导机制。对这些信号传导机制的充分理解在科学和临床上都很重要，因为它们的失败在影响全球数百万人的当代健康问题中起着直接作用，例如糖尿病，肥胖症，癌症，衰老，传染病，心血管疾病，神经退行性疾病和发育障碍。会议主题涵盖了从机械的角度来看，细胞内信号通路的网络，并继续强调从蛋白质共价修饰，蛋白质-蛋白质和蛋白质-核酸相互作用的研究中出现的前沿发现，以及小分子效应物的控制。新英格兰大学于2005年成为这次会议的新址，它提供了一个乡村风格和残疾人无障碍的场地，以促进与会者之间的公开互动。2006年会议将于6月11日星期日晚上举行，6月16日星期四晚上结束。鼓励演讲者整合生物化学，结构，细胞生物学和基因组学方法，这些方法提供了对与疾病相关的信号传导机制的分子方面的全面理解。两名全体发言人被选中为会议搭建舞台，并挑战与会者从化学-生物学界面的角度思考信号转导。会议将包括8场会议，每场会议有一名讨论负责人和3-5名发言人，发言人从最近作出重要贡献的调查人员中选出。至少45%的受邀发言者是妇女或少数群体成员，23%的受邀发言者是新调查员（助理/助理级）。在每个环节的发言者将发展信号转导的重要范例。重点将是对定义分子机制及其对疾病和潜在治疗策略的影响的结构和功能理解。联合主席将从申请者中选出135名参与者，包括来自工业界和学术界的代表、资深科学家、博士后研究员和研究生。将作出特别努力，通过直接发送电子邮件的方案招募少数族裔参与者和工业界参与者。鼓励参加者每天下午展示关于新的和有趣的结果的海报。重要的是，这次会议为年轻的研究人员提供了一个论坛，让他们看到基础科学探究与科学方法应用于设计人类疾病有效干预措施之间的联系。为了强调这一目标，将挑选8幅与会议主题相辅相成的海报，在主要会议期间作简短的口头介绍。

DESCRIPTION (provided by applicant): We request partial funding support for operation of the Gordon Research Conference (GRC) on Phosphorylation and G protein Signaling Networks. This conference, formerly known as "Second Messengers and Protein Phosphorylation" has been held annually since 1970, and has been a premier venue for the presentation of new discoveries in signal transduction. Investigators who initiated and attended this meeting from its inception were leaders who established the field of signal transduction, including several who have received Nobel Prizes (e.g., Earl Sutherland, Al Oilman, Stanley Cohen, Edwin Krebs, Edmond Fischer, Paul Nurse). The conference focuses on signal transduction mechanisms that regulate cell growth, differentiation, survival, and metabolism. A full understanding of these signaling mechanisms is scientifically and clinically important because their failure plays a direct role in contemporary health problems that affect millions of people worldwide, such as diabetes, obesity, cancer, aging, infectious disease, cardiovascular disease, neurodegeneration, and developmental disorders. Meeting topics cover networks of intracellular signaling pathways from a mechanistic viewpoint, and continue to highlight cutting edge discoveries by emerging from studies focused on protein covalent modifications, protein-protein and protein-nucleic acid interactions, and control by small molecule effectors. The University of New England became the new site for this meeting in 2005, and provides a rustic and handicapped-accessible venue to promote open interaction among participants. The 2006 meeting will be held from Sunday night June 11 and end on Thursday evening June 16. The speakers are encouraged to integrate biochemical, structural, cell-biological, and genomic approaches that provide a comprehensive understanding of the molecular aspects of signaling mechanisms as they relate to disease. Two plenary speakers were selected to set the stage for the conference and to challenge the participants to think about signal transduction from perspectives of the chemistry-biology interface. The conference will consist of 8 sessions, each with a discussion leader and 3-5 speakers, selected from investigators who have made important recent contributions. At least 45% of the invited speakers are either women or members of minority groups and 23% of invited speakers are new investigators (Asst/Assoc. level). Speakers in each session will develop the important paradigms in signal transduction. The emphasis will be on structural and functional understanding of the defining molecular mechanisms and their implications for disease and potential treatment strategies. The co-chairs will select 135 participants from applicants, including representatives from industry and academia, senior scientists, postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants and participants from industry by a direct emailing program. Participants will be encouraged to present posters on new and interesting results each afternoon. Importantly, the conference provides a forum for young investigators to see the connection between fundamental scientific inquiry and the application of scientific methods to the design of efficacious interventions for human disease. To emphasize this goal, 8 poster presentations that complement the themes of the meeting will be selected for short oral presentations during the main sessions.