Gordon Conference on "Phosphorylation and G Protein Signaling Networks"

戈登会议“磷酸化和 G 蛋白信号网络”

• 批准号: 7385961
• 负责人: Henrik G. Dohlman
• 金额: $ 1.27万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7385961
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DESCRIPTION (provided by applicant): We request partial funding support for operation of the Gordon Research Conference (GRC) on Phosphorylation and G protein Signaling Networks. This conference, formerly known as "Second Messengers and Protein Phosphorylation" has been held annually since 1970, and has been a premier venue for the presentation of new discoveries in signal transduction. Investigators who initiated and attended this meeting from its inception were leaders who established the field of signal transduction, including several who have received Nobel Prizes (e.g., Earl Sutherland, Al Oilman, Stanley Cohen, Edwin Krebs, Edmond Fischer, Paul Nurse). The conference focuses on signal transduction mechanisms that regulate cell growth, differentiation, survival, and metabolism. A full understanding of these signaling mechanisms is scientifically and clinically important because their failure plays a direct role in contemporary health problems that affect millions of people worldwide, such as diabetes, obesity, cancer, aging, infectious disease, cardiovascular disease, neurodegeneration, and developmental disorders. Meeting topics cover networks of intracellular signaling pathways from a mechanistic viewpoint, and continue to highlight cutting edge discoveries by emerging from studies focused on protein covalent modifications, protein-protein and protein-nucleic acid interactions, and control by small molecule effectors. The University of New England became the new site for this meeting in 2005, and provides a rustic and handicapped-accessible venue to promote open interaction among participants. The 2006 meeting will be held from Sunday night June 11 and end on Thursday evening June 16. The speakers are encouraged to integrate biochemical, structural, cell-biological, and genomic approaches that provide a comprehensive understanding of the molecular aspects of signaling mechanisms as they relate to disease. Two plenary speakers were selected to set the stage for the conference and to challenge the participants to think about signal transduction from perspectives of the chemistry-biology interface. The conference will consist of 8 sessions, each with a discussion leader and 3-5 speakers, selected from investigators who have made important recent contributions. At least 45% of the invited speakers are either women or members of minority groups and 23% of invited speakers are new investigators (Asst/Assoc. level). Speakers in each session will develop the important paradigms in signal transduction. The emphasis will be on structural and functional understanding of the defining molecular mechanisms and their implications for disease and potential treatment strategies. The co-chairs will select 135 participants from applicants, including representatives from industry and academia, senior scientists, postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants and participants from industry by a direct emailing program. Participants will be encouraged to present posters on new and interesting results each afternoon. Importantly, the conference provides a forum for young investigators to see the connection between fundamental scientific inquiry and the application of scientific methods to the design of efficacious interventions for human disease. To emphasize this goal, 8 poster presentations that complement the themes of the meeting will be selected for short oral presentations during the main sessions.

描述（由申请人提供）： 我们请求为戈登磷酸化和 G 蛋白信号网络研究会议 (GRC) 的运作提供部分资金支持。该会议以前称为“第二信使和蛋白质磷酸化”，自 1970 年以来每年举行一次，一直是展示信号转导新发现的首要场所。从一开始发起和参加这次会议的研究人员都是信号转导领域的开创者，其中包括几位获得诺贝尔奖的人（例如 Earl Sutherland、Al Oilman、Stanley Cohen、Edwin Krebs、Edmond Fischer、Paul Nurse）。会议重点关注调节细胞生长、分化、存活和代谢的信号转导机制。充分了解这些信号机制在科学和临床上都很重要，因为它们的失败在影响全世界数百万人的当代健康问题中发挥着直接作用，例如糖尿病、肥胖、癌症、衰老、传染病、心血管疾病、神经退行性疾病和发育障碍。会议主题从机制的角度涵盖细胞内信号通路网络，并继续强调蛋白质共价修饰、蛋白质-蛋白质和蛋白质-核酸相互作用以及小分子效应子控制等研究中出现的前沿发现。新英格兰大学于2005年成为这次会议的新场地，并提供了一个质朴且适合残疾人使用的场地，以促进与会者之间的开放互动。 2006 年会议将于 6 月 11 日星期日晚间举行，并于 6 月 16 日星期四晚间结束。我们鼓励发言者整合生化、结构、细胞生物学和基因组方法，以全面了解与疾病相关的信号机制的分子方面。两名全体会议发言人被选中为会议奠定基础，并挑战参与者从化学-生物学界面的角度思考信号转导。会议将由 8 场会议组成，每场会议有一名讨论主持人和 3-5 名发言者，发言者选自近期做出重要贡献的研究人员。至少 45% 的受邀演讲者是女性或少数群体成员，23% 的受邀演讲者是新研究者（助理/副级别）。每场会议的演讲者将发展信号转导的重要范例。重点是对定义分子机制的结构和功能理解及其对疾病和潜在治疗策略的影响。联合主席将从申请者中选出135名参会人员，包括来自工业界和学术界的代表、资深科学家、博士后和研究生。将特别努力通过直接电子邮件计划招募少数族裔参与者和行业参与者。我们将鼓励参与者每天下午展示有关新的、有趣的结果的海报。重要的是，这次会议为年轻研究人员提供了一个论坛，让他们了解基础科学探究与科学方法在设计人类疾病有效干预措施中的应用之间的联系。为了强调这一目标，将选择 8 个与会议主题相辅相成的海报展示，在主要会议期间进行简短的口头报告。